In vivo protective effect against ethanol metabolism and liver injury of oyster (Crassostrea Gigas) extracts obtained via subcritical water processing
The present study assesses hepatoprotective effects of raw oyster lyophilized powder (OP) and subcritical water treated oyster powder (SOP) on D-galactosamine (D-GalN)-induced toxicity and acute ethanol intoxication in mice. High-performance liquid chromatography analysis revealed that four phenolic...
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Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8364599/ http://www.ncbi.nlm.nih.gov/pubmed/34471560 https://doi.org/10.1007/s10068-021-00941-9 |
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ftpubmed:oai:pubmedcentral.nih.gov:8364599 2023-05-15T15:58:34+02:00 In vivo protective effect against ethanol metabolism and liver injury of oyster (Crassostrea Gigas) extracts obtained via subcritical water processing Lee, Hee-Jeong Saravana, Periaswamy Sivagnanam Ho, Truc Cong Cho, Yeon-Jin Park, Jin-Seok Lee, Sang-Gyu Chun, Byung-Soo 2021-07-26 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8364599/ http://www.ncbi.nlm.nih.gov/pubmed/34471560 https://doi.org/10.1007/s10068-021-00941-9 en eng Springer Singapore http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8364599/ http://www.ncbi.nlm.nih.gov/pubmed/34471560 http://dx.doi.org/10.1007/s10068-021-00941-9 © The Korean Society of Food Science and Technology 2021 Food Sci Biotechnol Research Article Text 2021 ftpubmed https://doi.org/10.1007/s10068-021-00941-9 2022-07-31T00:29:30Z The present study assesses hepatoprotective effects of raw oyster lyophilized powder (OP) and subcritical water treated oyster powder (SOP) on D-galactosamine (D-GalN)-induced toxicity and acute ethanol intoxication in mice. High-performance liquid chromatography analysis revealed that four phenolic compounds and glucose were identified from the SOP. The levels of aspartate aminotransferase, alanine aminotransferase, and malondialdehyde were considerably lower for the oyster extracts and the levels of glutathione, γ-glutamylcysteinesynthetase, glutathione S-transferase, and glutathione reductase were higher in the D-GalN induced mice compared with those in the controls. Histology analysis suggested that SOP can protect against and heal the D-GalN toxified liver. For the acute ethanol intoxication study, the enzymatic activity of acetaldehyde dehydrogenase and SOP’s alcohol dehydrogenase appeared better than that of OP. Overall, SOP may protect the liver from acute ethanol intoxication and D-GalN persuaded hepatitis. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10068-021-00941-9. Text Crassostrea gigas PubMed Central (PMC) Food Science and Biotechnology 30 8 1063 1074 |
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Research Article Lee, Hee-Jeong Saravana, Periaswamy Sivagnanam Ho, Truc Cong Cho, Yeon-Jin Park, Jin-Seok Lee, Sang-Gyu Chun, Byung-Soo In vivo protective effect against ethanol metabolism and liver injury of oyster (Crassostrea Gigas) extracts obtained via subcritical water processing |
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Research Article |
description |
The present study assesses hepatoprotective effects of raw oyster lyophilized powder (OP) and subcritical water treated oyster powder (SOP) on D-galactosamine (D-GalN)-induced toxicity and acute ethanol intoxication in mice. High-performance liquid chromatography analysis revealed that four phenolic compounds and glucose were identified from the SOP. The levels of aspartate aminotransferase, alanine aminotransferase, and malondialdehyde were considerably lower for the oyster extracts and the levels of glutathione, γ-glutamylcysteinesynthetase, glutathione S-transferase, and glutathione reductase were higher in the D-GalN induced mice compared with those in the controls. Histology analysis suggested that SOP can protect against and heal the D-GalN toxified liver. For the acute ethanol intoxication study, the enzymatic activity of acetaldehyde dehydrogenase and SOP’s alcohol dehydrogenase appeared better than that of OP. Overall, SOP may protect the liver from acute ethanol intoxication and D-GalN persuaded hepatitis. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10068-021-00941-9. |
format |
Text |
author |
Lee, Hee-Jeong Saravana, Periaswamy Sivagnanam Ho, Truc Cong Cho, Yeon-Jin Park, Jin-Seok Lee, Sang-Gyu Chun, Byung-Soo |
author_facet |
Lee, Hee-Jeong Saravana, Periaswamy Sivagnanam Ho, Truc Cong Cho, Yeon-Jin Park, Jin-Seok Lee, Sang-Gyu Chun, Byung-Soo |
author_sort |
Lee, Hee-Jeong |
title |
In vivo protective effect against ethanol metabolism and liver injury of oyster (Crassostrea Gigas) extracts obtained via subcritical water processing |
title_short |
In vivo protective effect against ethanol metabolism and liver injury of oyster (Crassostrea Gigas) extracts obtained via subcritical water processing |
title_full |
In vivo protective effect against ethanol metabolism and liver injury of oyster (Crassostrea Gigas) extracts obtained via subcritical water processing |
title_fullStr |
In vivo protective effect against ethanol metabolism and liver injury of oyster (Crassostrea Gigas) extracts obtained via subcritical water processing |
title_full_unstemmed |
In vivo protective effect against ethanol metabolism and liver injury of oyster (Crassostrea Gigas) extracts obtained via subcritical water processing |
title_sort |
in vivo protective effect against ethanol metabolism and liver injury of oyster (crassostrea gigas) extracts obtained via subcritical water processing |
publisher |
Springer Singapore |
publishDate |
2021 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8364599/ http://www.ncbi.nlm.nih.gov/pubmed/34471560 https://doi.org/10.1007/s10068-021-00941-9 |
genre |
Crassostrea gigas |
genre_facet |
Crassostrea gigas |
op_source |
Food Sci Biotechnol |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8364599/ http://www.ncbi.nlm.nih.gov/pubmed/34471560 http://dx.doi.org/10.1007/s10068-021-00941-9 |
op_rights |
© The Korean Society of Food Science and Technology 2021 |
op_doi |
https://doi.org/10.1007/s10068-021-00941-9 |
container_title |
Food Science and Biotechnology |
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30 |
container_issue |
8 |
container_start_page |
1063 |
op_container_end_page |
1074 |
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1766394337733640192 |