Effect of high intake of cod or salmon on serum total neopterin concentration: a randomised clinical trial
PURPOSE: Primarily, to investigate the effect of high intake of cod (lean fish) or salmon (fatty fish) on serum concentration of total neopterin, a marker of cellular immune activation that is associated with cardiovascular disease. Second, to investigate effects of high cod/salmon intake on antioxi...
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Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8354862/ http://www.ncbi.nlm.nih.gov/pubmed/33576844 https://doi.org/10.1007/s00394-021-02497-0 |
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ftpubmed:oai:pubmedcentral.nih.gov:8354862 2023-05-15T15:27:42+02:00 Effect of high intake of cod or salmon on serum total neopterin concentration: a randomised clinical trial Helland, Anita Bratlie, Marianne Hagen, Ingrid V. Midttun, Øivind Sveier, Harald Mellgren, Gunnar Ueland, Per Magne Gudbrandsen, Oddrun A. 2021-02-12 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8354862/ http://www.ncbi.nlm.nih.gov/pubmed/33576844 https://doi.org/10.1007/s00394-021-02497-0 en eng Springer Berlin Heidelberg http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8354862/ http://www.ncbi.nlm.nih.gov/pubmed/33576844 http://dx.doi.org/10.1007/s00394-021-02497-0 © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . CC-BY Eur J Nutr Original Contribution Text 2021 ftpubmed https://doi.org/10.1007/s00394-021-02497-0 2021-08-29T00:25:30Z PURPOSE: Primarily, to investigate the effect of high intake of cod (lean fish) or salmon (fatty fish) on serum concentration of total neopterin, a marker of cellular immune activation that is associated with cardiovascular disease. Second, to investigate effects of high cod/salmon intake on antioxidant vitamins and elements essential for activity of antioxidant enzymes. METHODS: In this randomised clinical trial, 63 participants with overweight/obesity consumed 750 g/week of either Atlantic cod (N = 22) or Atlantic salmon (N = 22) or were instructed to continue their normal eating habits but avoid fish intake (Control group, N = 19) for 8 weeks. Food intake was recorded, and fasting serum were collected at baseline and endpoint. RESULTS: Serum total neopterin concentration was reduced in the Cod group (median change − 2.65 (25th, 75th percentiles − 3.68, − 0.45) nmol/l, P = 0.018) but not in the Salmon group (median change 0.00 (25th, 75th percentiles − 4.15, 3.05) nmol/l, P = 0.59) when compared with the Control group after 8 weeks. The estimated daily intake of selenium, iron, magnesium and zinc were similar between all groups. Increased serum concentration of selenium was observed only after cod intake when compared to the Control group (P = 0.017). Changes in serum concentrations of copper, iron, magnesium, all-trans retinol, α-tocopherol and γ-tocopherol were similar between the groups. CONCLUSION: A high intake of cod, but not of salmon, lowered serum total neopterin concentration when compared to the Control group. CLINICAL TRIAL REGISTRATION: This trial was registered at clinicaltrials.gov as NCT02350595 Text atlantic cod Atlantic salmon PubMed Central (PMC) European Journal of Nutrition 60 6 3237 3248 |
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Original Contribution |
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Original Contribution Helland, Anita Bratlie, Marianne Hagen, Ingrid V. Midttun, Øivind Sveier, Harald Mellgren, Gunnar Ueland, Per Magne Gudbrandsen, Oddrun A. Effect of high intake of cod or salmon on serum total neopterin concentration: a randomised clinical trial |
topic_facet |
Original Contribution |
description |
PURPOSE: Primarily, to investigate the effect of high intake of cod (lean fish) or salmon (fatty fish) on serum concentration of total neopterin, a marker of cellular immune activation that is associated with cardiovascular disease. Second, to investigate effects of high cod/salmon intake on antioxidant vitamins and elements essential for activity of antioxidant enzymes. METHODS: In this randomised clinical trial, 63 participants with overweight/obesity consumed 750 g/week of either Atlantic cod (N = 22) or Atlantic salmon (N = 22) or were instructed to continue their normal eating habits but avoid fish intake (Control group, N = 19) for 8 weeks. Food intake was recorded, and fasting serum were collected at baseline and endpoint. RESULTS: Serum total neopterin concentration was reduced in the Cod group (median change − 2.65 (25th, 75th percentiles − 3.68, − 0.45) nmol/l, P = 0.018) but not in the Salmon group (median change 0.00 (25th, 75th percentiles − 4.15, 3.05) nmol/l, P = 0.59) when compared with the Control group after 8 weeks. The estimated daily intake of selenium, iron, magnesium and zinc were similar between all groups. Increased serum concentration of selenium was observed only after cod intake when compared to the Control group (P = 0.017). Changes in serum concentrations of copper, iron, magnesium, all-trans retinol, α-tocopherol and γ-tocopherol were similar between the groups. CONCLUSION: A high intake of cod, but not of salmon, lowered serum total neopterin concentration when compared to the Control group. CLINICAL TRIAL REGISTRATION: This trial was registered at clinicaltrials.gov as NCT02350595 |
format |
Text |
author |
Helland, Anita Bratlie, Marianne Hagen, Ingrid V. Midttun, Øivind Sveier, Harald Mellgren, Gunnar Ueland, Per Magne Gudbrandsen, Oddrun A. |
author_facet |
Helland, Anita Bratlie, Marianne Hagen, Ingrid V. Midttun, Øivind Sveier, Harald Mellgren, Gunnar Ueland, Per Magne Gudbrandsen, Oddrun A. |
author_sort |
Helland, Anita |
title |
Effect of high intake of cod or salmon on serum total neopterin concentration: a randomised clinical trial |
title_short |
Effect of high intake of cod or salmon on serum total neopterin concentration: a randomised clinical trial |
title_full |
Effect of high intake of cod or salmon on serum total neopterin concentration: a randomised clinical trial |
title_fullStr |
Effect of high intake of cod or salmon on serum total neopterin concentration: a randomised clinical trial |
title_full_unstemmed |
Effect of high intake of cod or salmon on serum total neopterin concentration: a randomised clinical trial |
title_sort |
effect of high intake of cod or salmon on serum total neopterin concentration: a randomised clinical trial |
publisher |
Springer Berlin Heidelberg |
publishDate |
2021 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8354862/ http://www.ncbi.nlm.nih.gov/pubmed/33576844 https://doi.org/10.1007/s00394-021-02497-0 |
genre |
atlantic cod Atlantic salmon |
genre_facet |
atlantic cod Atlantic salmon |
op_source |
Eur J Nutr |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8354862/ http://www.ncbi.nlm.nih.gov/pubmed/33576844 http://dx.doi.org/10.1007/s00394-021-02497-0 |
op_rights |
© The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1007/s00394-021-02497-0 |
container_title |
European Journal of Nutrition |
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60 |
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6 |
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3237 |
op_container_end_page |
3248 |
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1766358119902871552 |