Validating Acute Myocardial Infarction Diagnoses in National Health Registers for Use as Endpoint in Research: The Tromsø Study
PURPOSE: To assess whether acute myocardial infarction (MI) diagnoses in national health registers are sufficiently correct and complete to replace manual collection of endpoint data for a population-based, epidemiological study. PATIENTS AND METHODS: Using the Tromsø Study Cardiovascular Disease Re...
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Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8349192/ http://www.ncbi.nlm.nih.gov/pubmed/34377033 https://doi.org/10.2147/CLEP.S321293 |
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ftpubmed:oai:pubmedcentral.nih.gov:8349192 2023-05-15T18:34:21+02:00 Validating Acute Myocardial Infarction Diagnoses in National Health Registers for Use as Endpoint in Research: The Tromsø Study Varmdal, Torunn Mathiesen, Ellisiv B Wilsgaard, Tom Njølstad, Inger Nyrnes, Audhild Grimsgaard, Sameline Bønaa, Kaare Harald Mannsverk, Jan Løchen, Maja-Lisa 2021-08-03 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8349192/ http://www.ncbi.nlm.nih.gov/pubmed/34377033 https://doi.org/10.2147/CLEP.S321293 en eng Dove http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8349192/ http://www.ncbi.nlm.nih.gov/pubmed/34377033 http://dx.doi.org/10.2147/CLEP.S321293 © 2021 Varmdal et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). CC-BY-NC Clin Epidemiol Original Research Text 2021 ftpubmed https://doi.org/10.2147/CLEP.S321293 2021-08-15T00:42:32Z PURPOSE: To assess whether acute myocardial infarction (MI) diagnoses in national health registers are sufficiently correct and complete to replace manual collection of endpoint data for a population-based, epidemiological study. PATIENTS AND METHODS: Using the Tromsø Study Cardiovascular Disease Register for 2013–2014 as gold standard, we calculated correctness (defined as positive predictive value (PPV)) and completeness (defined as sensitivity) of MI cases in the Norwegian Myocardial Infarction Register and the Norwegian Patient Register separately and in combination. We calculated the sensitivity and PPV with 95% confidence intervals using the Clopper-Pearson Exact test. RESULTS: We identified 153 MI cases in the gold standard. In the Norwegian Myocardial Infarction Register, we found a PPV of 97.1% (95% confidence interval (CI) 92.8–99.2) and a sensitivity of 88.2% (95% CI 82.0–92.9). In the Norwegian Patient Register, the PPV was 96.3% (95% CI 91.6–98.8) and the sensitivity was 85.6% (95% CI 79.0–90.8). The combined dataset of the Norwegian Myocardial Infarction Register and the Norwegian Patient Register had a PPV of 96.6% (95% CI 92.1–98.9) and a sensitivity of 91.5% (95% CI 85.9–95.4). CONCLUSION: MI diagnoses in both the Norwegian Myocardial Infarction Register and the Norwegian Patient Register were highly correct and complete, and each of the registers could be considered as endpoint sources for the Tromsø Study. A combination of the two national registers seemed, however, to represent the most comprehensive data source overall. The benefits of using data from national registers as endpoints in epidemiological studies include faster, less resource-intensive access to nationwide data and considerably lower loss to follow-up, compared to manual data collection in a limited geographical area. Text Tromsø PubMed Central (PMC) Tromsø Clinical Epidemiology Volume 13 675 682 |
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Original Research Varmdal, Torunn Mathiesen, Ellisiv B Wilsgaard, Tom Njølstad, Inger Nyrnes, Audhild Grimsgaard, Sameline Bønaa, Kaare Harald Mannsverk, Jan Løchen, Maja-Lisa Validating Acute Myocardial Infarction Diagnoses in National Health Registers for Use as Endpoint in Research: The Tromsø Study |
topic_facet |
Original Research |
description |
PURPOSE: To assess whether acute myocardial infarction (MI) diagnoses in national health registers are sufficiently correct and complete to replace manual collection of endpoint data for a population-based, epidemiological study. PATIENTS AND METHODS: Using the Tromsø Study Cardiovascular Disease Register for 2013–2014 as gold standard, we calculated correctness (defined as positive predictive value (PPV)) and completeness (defined as sensitivity) of MI cases in the Norwegian Myocardial Infarction Register and the Norwegian Patient Register separately and in combination. We calculated the sensitivity and PPV with 95% confidence intervals using the Clopper-Pearson Exact test. RESULTS: We identified 153 MI cases in the gold standard. In the Norwegian Myocardial Infarction Register, we found a PPV of 97.1% (95% confidence interval (CI) 92.8–99.2) and a sensitivity of 88.2% (95% CI 82.0–92.9). In the Norwegian Patient Register, the PPV was 96.3% (95% CI 91.6–98.8) and the sensitivity was 85.6% (95% CI 79.0–90.8). The combined dataset of the Norwegian Myocardial Infarction Register and the Norwegian Patient Register had a PPV of 96.6% (95% CI 92.1–98.9) and a sensitivity of 91.5% (95% CI 85.9–95.4). CONCLUSION: MI diagnoses in both the Norwegian Myocardial Infarction Register and the Norwegian Patient Register were highly correct and complete, and each of the registers could be considered as endpoint sources for the Tromsø Study. A combination of the two national registers seemed, however, to represent the most comprehensive data source overall. The benefits of using data from national registers as endpoints in epidemiological studies include faster, less resource-intensive access to nationwide data and considerably lower loss to follow-up, compared to manual data collection in a limited geographical area. |
format |
Text |
author |
Varmdal, Torunn Mathiesen, Ellisiv B Wilsgaard, Tom Njølstad, Inger Nyrnes, Audhild Grimsgaard, Sameline Bønaa, Kaare Harald Mannsverk, Jan Løchen, Maja-Lisa |
author_facet |
Varmdal, Torunn Mathiesen, Ellisiv B Wilsgaard, Tom Njølstad, Inger Nyrnes, Audhild Grimsgaard, Sameline Bønaa, Kaare Harald Mannsverk, Jan Løchen, Maja-Lisa |
author_sort |
Varmdal, Torunn |
title |
Validating Acute Myocardial Infarction Diagnoses in National Health Registers for Use as Endpoint in Research: The Tromsø Study |
title_short |
Validating Acute Myocardial Infarction Diagnoses in National Health Registers for Use as Endpoint in Research: The Tromsø Study |
title_full |
Validating Acute Myocardial Infarction Diagnoses in National Health Registers for Use as Endpoint in Research: The Tromsø Study |
title_fullStr |
Validating Acute Myocardial Infarction Diagnoses in National Health Registers for Use as Endpoint in Research: The Tromsø Study |
title_full_unstemmed |
Validating Acute Myocardial Infarction Diagnoses in National Health Registers for Use as Endpoint in Research: The Tromsø Study |
title_sort |
validating acute myocardial infarction diagnoses in national health registers for use as endpoint in research: the tromsø study |
publisher |
Dove |
publishDate |
2021 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8349192/ http://www.ncbi.nlm.nih.gov/pubmed/34377033 https://doi.org/10.2147/CLEP.S321293 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_source |
Clin Epidemiol |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8349192/ http://www.ncbi.nlm.nih.gov/pubmed/34377033 http://dx.doi.org/10.2147/CLEP.S321293 |
op_rights |
© 2021 Varmdal et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
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CC-BY-NC |
op_doi |
https://doi.org/10.2147/CLEP.S321293 |
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Clinical Epidemiology |
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Volume 13 |
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675 |
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682 |
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1766219048395210752 |