Hybridization with mountain hares increases the functional allelic repertoire in brown hares
Brown hares (Lepus europaeus Pallas) are able to hybridize with mountain hares (L. timidus Linnaeus) and produce fertile offspring, which results in cross-species gene flow. However, not much is known about the functional significance of this genetic introgression. Using targeted sequencing of candi...
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ftpubmed:oai:pubmedcentral.nih.gov:8338973 2023-05-15T17:13:25+02:00 Hybridization with mountain hares increases the functional allelic repertoire in brown hares Pohjoismäki, Jaakko L. O. Michell, Craig Levänen, Riikka Smith, Steve 2021-08-04 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8338973/ https://doi.org/10.1038/s41598-021-95357-0 en eng Nature Publishing Group UK http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8338973/ http://dx.doi.org/10.1038/s41598-021-95357-0 © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . CC-BY Sci Rep Article Text 2021 ftpubmed https://doi.org/10.1038/s41598-021-95357-0 2021-08-08T01:05:08Z Brown hares (Lepus europaeus Pallas) are able to hybridize with mountain hares (L. timidus Linnaeus) and produce fertile offspring, which results in cross-species gene flow. However, not much is known about the functional significance of this genetic introgression. Using targeted sequencing of candidate loci combined with mtDNA genotyping, we found the ancestral genetic diversity in the Finnish brown hare to be small, likely due to founder effect and range expansion, while gene flow from mountain hares constitutes an important source of functional genetic variability. Some of this variability, such as the alleles of the mountain hare thermogenin (uncoupling protein 1, UCP1), might have adaptive advantage for brown hares, whereas immunity-related MHC alleles are reciprocally exchanged and maintained via balancing selection. Our study offers a rare example where an expanding species can increase its allelic variability through hybridization with a congeneric native species, offering a route to shortcut evolutionary adaptation to the local environmental conditions. Text mountain hare PubMed Central (PMC) Scientific Reports 11 1 |
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Article Pohjoismäki, Jaakko L. O. Michell, Craig Levänen, Riikka Smith, Steve Hybridization with mountain hares increases the functional allelic repertoire in brown hares |
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Article |
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Brown hares (Lepus europaeus Pallas) are able to hybridize with mountain hares (L. timidus Linnaeus) and produce fertile offspring, which results in cross-species gene flow. However, not much is known about the functional significance of this genetic introgression. Using targeted sequencing of candidate loci combined with mtDNA genotyping, we found the ancestral genetic diversity in the Finnish brown hare to be small, likely due to founder effect and range expansion, while gene flow from mountain hares constitutes an important source of functional genetic variability. Some of this variability, such as the alleles of the mountain hare thermogenin (uncoupling protein 1, UCP1), might have adaptive advantage for brown hares, whereas immunity-related MHC alleles are reciprocally exchanged and maintained via balancing selection. Our study offers a rare example where an expanding species can increase its allelic variability through hybridization with a congeneric native species, offering a route to shortcut evolutionary adaptation to the local environmental conditions. |
format |
Text |
author |
Pohjoismäki, Jaakko L. O. Michell, Craig Levänen, Riikka Smith, Steve |
author_facet |
Pohjoismäki, Jaakko L. O. Michell, Craig Levänen, Riikka Smith, Steve |
author_sort |
Pohjoismäki, Jaakko L. O. |
title |
Hybridization with mountain hares increases the functional allelic repertoire in brown hares |
title_short |
Hybridization with mountain hares increases the functional allelic repertoire in brown hares |
title_full |
Hybridization with mountain hares increases the functional allelic repertoire in brown hares |
title_fullStr |
Hybridization with mountain hares increases the functional allelic repertoire in brown hares |
title_full_unstemmed |
Hybridization with mountain hares increases the functional allelic repertoire in brown hares |
title_sort |
hybridization with mountain hares increases the functional allelic repertoire in brown hares |
publisher |
Nature Publishing Group UK |
publishDate |
2021 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8338973/ https://doi.org/10.1038/s41598-021-95357-0 |
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mountain hare |
genre_facet |
mountain hare |
op_source |
Sci Rep |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8338973/ http://dx.doi.org/10.1038/s41598-021-95357-0 |
op_rights |
© The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
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CC-BY |
op_doi |
https://doi.org/10.1038/s41598-021-95357-0 |
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Scientific Reports |
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11 |
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