Analysis of Antigens in Mycobacterium Paratuberculosis
Analysis of antigens in Mycobacterium paratuberculosis. Acta vet. scand. 1979, 20, 200–215. — Using crossed immunoelectrophoresis (GIE) and crossed line immunoelectrophoresis (GLIE), antigens from different strains and variants of Mycobacterium paratuberculosis were compared, and cross-reactions bet...
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ftpubmed:oai:pubmedcentral.nih.gov:8322891 2023-05-15T16:51:45+02:00 Analysis of Antigens in Mycobacterium Paratuberculosis Gunnarsson, Eggert Fodstad, Finn H. 1979-06-01 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8322891/ http://www.ncbi.nlm.nih.gov/pubmed/90456 https://doi.org/10.1186/BF03546612 en eng BioMed Central http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8322891/ http://www.ncbi.nlm.nih.gov/pubmed/90456 http://dx.doi.org/10.1186/BF03546612 © The Author(s) 1979 Acta Vet Scand Article Text 1979 ftpubmed https://doi.org/10.1186/BF03546612 2021-08-08T00:44:37Z Analysis of antigens in Mycobacterium paratuberculosis. Acta vet. scand. 1979, 20, 200–215. — Using crossed immunoelectrophoresis (GIE) and crossed line immunoelectrophoresis (GLIE), antigens from different strains and variants of Mycobacterium paratuberculosis were compared, and cross-reactions between 1 of these strains and Mycobacterium avium and BGG studied. In each of 4 bovine laboratory strains of M. paratuberculosis examined, altogether 44 different antigens were demonstrated. This is the largest number of antigens in M. paratuberculosis which has been described so far. No important difference in the antigenic structure of the strains was found. The 4 laboratory strains are being used routinely in the production of vaccine against Johne’s disease in Norway and Iceland. One of the aims of the present work was to investigate the antigenic relationship between these strains and the goat-pathogenic Norwegian and the Icelandic variant of M. paratuberculosis. Out of 44 different antigens demonstrated in the laboratory strains, 39 and 31 gave cross-reactions against the Norwegian and the Icelandic variant, respectively. This is in accordance with practical experience, as the results of vaccination against Johne’s disease, performed in Norway for many years, are very good. Twenty-seven and 24 cross-reacting antigens between M. paratuberculosis and strains of M. avium and BGG, respectively, were observed. This finding agrees with clinical observations. Another aim of the investigation was to identify species-specific antigens as regards M. paratuberculosis. One antigen showed a marked cross-reaction between the strains of M. paratuberculosis examined, but did not react with antisera against M. avium and BGG. Some other antigens showed partial specificity. The results obtained stress the complicated antigenic situation in mycobacteria which is of decisive significance as regards the diagnosis and classification of mycobacterial infections. Text Iceland PubMed Central (PMC) Norway Acta Veterinaria Scandinavica 20 2 200 215 |
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Article Gunnarsson, Eggert Fodstad, Finn H. Analysis of Antigens in Mycobacterium Paratuberculosis |
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Article |
description |
Analysis of antigens in Mycobacterium paratuberculosis. Acta vet. scand. 1979, 20, 200–215. — Using crossed immunoelectrophoresis (GIE) and crossed line immunoelectrophoresis (GLIE), antigens from different strains and variants of Mycobacterium paratuberculosis were compared, and cross-reactions between 1 of these strains and Mycobacterium avium and BGG studied. In each of 4 bovine laboratory strains of M. paratuberculosis examined, altogether 44 different antigens were demonstrated. This is the largest number of antigens in M. paratuberculosis which has been described so far. No important difference in the antigenic structure of the strains was found. The 4 laboratory strains are being used routinely in the production of vaccine against Johne’s disease in Norway and Iceland. One of the aims of the present work was to investigate the antigenic relationship between these strains and the goat-pathogenic Norwegian and the Icelandic variant of M. paratuberculosis. Out of 44 different antigens demonstrated in the laboratory strains, 39 and 31 gave cross-reactions against the Norwegian and the Icelandic variant, respectively. This is in accordance with practical experience, as the results of vaccination against Johne’s disease, performed in Norway for many years, are very good. Twenty-seven and 24 cross-reacting antigens between M. paratuberculosis and strains of M. avium and BGG, respectively, were observed. This finding agrees with clinical observations. Another aim of the investigation was to identify species-specific antigens as regards M. paratuberculosis. One antigen showed a marked cross-reaction between the strains of M. paratuberculosis examined, but did not react with antisera against M. avium and BGG. Some other antigens showed partial specificity. The results obtained stress the complicated antigenic situation in mycobacteria which is of decisive significance as regards the diagnosis and classification of mycobacterial infections. |
format |
Text |
author |
Gunnarsson, Eggert Fodstad, Finn H. |
author_facet |
Gunnarsson, Eggert Fodstad, Finn H. |
author_sort |
Gunnarsson, Eggert |
title |
Analysis of Antigens in Mycobacterium Paratuberculosis |
title_short |
Analysis of Antigens in Mycobacterium Paratuberculosis |
title_full |
Analysis of Antigens in Mycobacterium Paratuberculosis |
title_fullStr |
Analysis of Antigens in Mycobacterium Paratuberculosis |
title_full_unstemmed |
Analysis of Antigens in Mycobacterium Paratuberculosis |
title_sort |
analysis of antigens in mycobacterium paratuberculosis |
publisher |
BioMed Central |
publishDate |
1979 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8322891/ http://www.ncbi.nlm.nih.gov/pubmed/90456 https://doi.org/10.1186/BF03546612 |
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Norway |
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Norway |
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Iceland |
genre_facet |
Iceland |
op_source |
Acta Vet Scand |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8322891/ http://www.ncbi.nlm.nih.gov/pubmed/90456 http://dx.doi.org/10.1186/BF03546612 |
op_rights |
© The Author(s) 1979 |
op_doi |
https://doi.org/10.1186/BF03546612 |
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Acta Veterinaria Scandinavica |
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20 |
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2 |
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200 |
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215 |
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1766041861211815936 |