Teratogenicity and Embryotoxicity of Orally Administered Fenchlorphos in Blue Foxes
Pregnant blue foxes (Alopex lagopus) were administered fenchlorphos (0-0-dimethyl-0-(2,4,5-trichlorophenyl) phos-phorothioate) orally at a dose of 100 mg/kg/day in different periods of gestation. The dose chosen represents the therapeutic dose for the treatment of parasitic lesions. At term the mean...
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ftpubmed:oai:pubmedcentral.nih.gov:8291249 2023-05-15T13:19:50+02:00 Teratogenicity and Embryotoxicity of Orally Administered Fenchlorphos in Blue Foxes Berge, Gunnar N. Nafstad, Inger 1983-03-01 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8291249/ http://www.ncbi.nlm.nih.gov/pubmed/6191556 https://doi.org/10.1186/BF03546761 en eng BioMed Central http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8291249/ http://www.ncbi.nlm.nih.gov/pubmed/6191556 http://dx.doi.org/10.1186/BF03546761 © The Author(s) 1983 Acta Vet Scand Article Text 1983 ftpubmed https://doi.org/10.1186/BF03546761 2021-07-25T00:45:44Z Pregnant blue foxes (Alopex lagopus) were administered fenchlorphos (0-0-dimethyl-0-(2,4,5-trichlorophenyl) phos-phorothioate) orally at a dose of 100 mg/kg/day in different periods of gestation. The dose chosen represents the therapeutic dose for the treatment of parasitic lesions. At term the mean number of whelps were recorded, and they were killed and examined for external, visceral and skeletal malformations. Of 19 medicated vixens the mean number of live whelps at term was 1.2 per vixen versus 9.5 in the control group. There was an evident predominance of males in the medicated groups. Several malformations of the head were registered, among them incomplete ossification of the skull bones, cleft palate, hydrocephalus internus and externus. Minor malformations like extra ribs or missing ribs occurred in the medicated groups. Congenital alopecia, hypoplastic kidneys, and hydronephrosis were observed in all the whelps in 1 medicated group. No significant difference in total brain weight, cerebellum weight or the cerebellum-to-total-brain weight was observed. Histological examination of the cerebellum showed a narrowing or absence of the granular and the molecular layers of the cortical zone. Text Alopex lagopus PubMed Central (PMC) Acta Veterinaria Scandinavica 24 1 99 112 |
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Article Berge, Gunnar N. Nafstad, Inger Teratogenicity and Embryotoxicity of Orally Administered Fenchlorphos in Blue Foxes |
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description |
Pregnant blue foxes (Alopex lagopus) were administered fenchlorphos (0-0-dimethyl-0-(2,4,5-trichlorophenyl) phos-phorothioate) orally at a dose of 100 mg/kg/day in different periods of gestation. The dose chosen represents the therapeutic dose for the treatment of parasitic lesions. At term the mean number of whelps were recorded, and they were killed and examined for external, visceral and skeletal malformations. Of 19 medicated vixens the mean number of live whelps at term was 1.2 per vixen versus 9.5 in the control group. There was an evident predominance of males in the medicated groups. Several malformations of the head were registered, among them incomplete ossification of the skull bones, cleft palate, hydrocephalus internus and externus. Minor malformations like extra ribs or missing ribs occurred in the medicated groups. Congenital alopecia, hypoplastic kidneys, and hydronephrosis were observed in all the whelps in 1 medicated group. No significant difference in total brain weight, cerebellum weight or the cerebellum-to-total-brain weight was observed. Histological examination of the cerebellum showed a narrowing or absence of the granular and the molecular layers of the cortical zone. |
format |
Text |
author |
Berge, Gunnar N. Nafstad, Inger |
author_facet |
Berge, Gunnar N. Nafstad, Inger |
author_sort |
Berge, Gunnar N. |
title |
Teratogenicity and Embryotoxicity of Orally Administered Fenchlorphos in Blue Foxes |
title_short |
Teratogenicity and Embryotoxicity of Orally Administered Fenchlorphos in Blue Foxes |
title_full |
Teratogenicity and Embryotoxicity of Orally Administered Fenchlorphos in Blue Foxes |
title_fullStr |
Teratogenicity and Embryotoxicity of Orally Administered Fenchlorphos in Blue Foxes |
title_full_unstemmed |
Teratogenicity and Embryotoxicity of Orally Administered Fenchlorphos in Blue Foxes |
title_sort |
teratogenicity and embryotoxicity of orally administered fenchlorphos in blue foxes |
publisher |
BioMed Central |
publishDate |
1983 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8291249/ http://www.ncbi.nlm.nih.gov/pubmed/6191556 https://doi.org/10.1186/BF03546761 |
genre |
Alopex lagopus |
genre_facet |
Alopex lagopus |
op_source |
Acta Vet Scand |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8291249/ http://www.ncbi.nlm.nih.gov/pubmed/6191556 http://dx.doi.org/10.1186/BF03546761 |
op_rights |
© The Author(s) 1983 |
op_doi |
https://doi.org/10.1186/BF03546761 |
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Acta Veterinaria Scandinavica |
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24 |
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1 |
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99 |
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112 |
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1766349814935584768 |