Clinical and biochemical signs of polycystic ovary syndrome in young women born preterm
OBJECTIVE: It has been suggested that adverse early life exposures increase the risk of developing polycystic ovary syndrome (PCOS) in later life. We hypothesized that women born preterm would have more biochemical and clinical signs of PCOS than women born at term. DESIGN: The ESTER Preterm Birth S...
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ftpubmed:oai:pubmedcentral.nih.gov:8284903 2023-05-15T17:42:20+02:00 Clinical and biochemical signs of polycystic ovary syndrome in young women born preterm Paalanne, Marika Vääräsmäki, Marja Mustaniemi, Sanna Tikanmäki, Marjaana Wehkalampi, Karoliina Matinolli, Hanna-Maria Eriksson, Johan Järvelin, Marjo-Riitta Morin-Papunen, Laure Kajantie, Eero 2021-06-03 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8284903/ http://www.ncbi.nlm.nih.gov/pubmed/34081616 https://doi.org/10.1530/EJE-20-1462 en eng Bioscientifica Ltd http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8284903/ http://www.ncbi.nlm.nih.gov/pubmed/34081616 http://dx.doi.org/10.1530/EJE-20-1462 © The authors https://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) . CC-BY Eur J Endocrinol Clinical Study Text 2021 ftpubmed https://doi.org/10.1530/EJE-20-1462 2021-07-25T00:36:44Z OBJECTIVE: It has been suggested that adverse early life exposures increase the risk of developing polycystic ovary syndrome (PCOS) in later life. We hypothesized that women born preterm would have more biochemical and clinical signs of PCOS than women born at term. DESIGN: The ESTER Preterm Birth Study participants were born in Northern Finland and identified from the Northern Finland Birth Cohort and the Finnish Medical Birth Register. Altogether, 74 women born very or moderately preterm (<34 gestational weeks, VMPT), 127 born late preterm (at 34–36 weeks, LPT), and 184 born full term (≥37 weeks, controls) were included in the analysis (mean age: 23.2 years). METHODS: We measured serum total testosterone and sex hormone-binding globulin (SHBG) and calculated the free androgen index (FAI). PCOS according to the clinical and biochemical signs was defined either as hirsutism and oligoamenorrhea (via questionnaire) or as oligoamenorrhea and elevated testosterone levels (>2.4 nmol/L). RESULTS: Women born VMPT/LPT exhibited 33.0% (8.7, 62.8)/16.4% (−2.0, 38.1) higher testosterone, 28.5% (5.3, 45.9)/24.1% (5.6, 38.9) lower SHBG levels, and 64.6% (19.4, 127.1)/42.5% (11.1, 82.9) higher FAI than controls after adjusting for age and recruitment cohort, maternal BMI, smoking, and pregnancy disorders, parental education, history of hypertension, diabetes, myocardial infarction or stroke, and subject’s birth weight s.d. Odds ratios for having PCOS were 1.67 (0.44, 6.23)/3.11 (1.26, 7.70). CONCLUSIONS: Women born preterm have a more hyperandrogenic hormonal profile, and those born LPT are approximately three times more likely at risk to have PCOS compared to women born at term. Text Northern Finland PubMed Central (PMC) European Journal of Endocrinology 185 2 279 288 |
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Clinical Study |
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Clinical Study Paalanne, Marika Vääräsmäki, Marja Mustaniemi, Sanna Tikanmäki, Marjaana Wehkalampi, Karoliina Matinolli, Hanna-Maria Eriksson, Johan Järvelin, Marjo-Riitta Morin-Papunen, Laure Kajantie, Eero Clinical and biochemical signs of polycystic ovary syndrome in young women born preterm |
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Clinical Study |
description |
OBJECTIVE: It has been suggested that adverse early life exposures increase the risk of developing polycystic ovary syndrome (PCOS) in later life. We hypothesized that women born preterm would have more biochemical and clinical signs of PCOS than women born at term. DESIGN: The ESTER Preterm Birth Study participants were born in Northern Finland and identified from the Northern Finland Birth Cohort and the Finnish Medical Birth Register. Altogether, 74 women born very or moderately preterm (<34 gestational weeks, VMPT), 127 born late preterm (at 34–36 weeks, LPT), and 184 born full term (≥37 weeks, controls) were included in the analysis (mean age: 23.2 years). METHODS: We measured serum total testosterone and sex hormone-binding globulin (SHBG) and calculated the free androgen index (FAI). PCOS according to the clinical and biochemical signs was defined either as hirsutism and oligoamenorrhea (via questionnaire) or as oligoamenorrhea and elevated testosterone levels (>2.4 nmol/L). RESULTS: Women born VMPT/LPT exhibited 33.0% (8.7, 62.8)/16.4% (−2.0, 38.1) higher testosterone, 28.5% (5.3, 45.9)/24.1% (5.6, 38.9) lower SHBG levels, and 64.6% (19.4, 127.1)/42.5% (11.1, 82.9) higher FAI than controls after adjusting for age and recruitment cohort, maternal BMI, smoking, and pregnancy disorders, parental education, history of hypertension, diabetes, myocardial infarction or stroke, and subject’s birth weight s.d. Odds ratios for having PCOS were 1.67 (0.44, 6.23)/3.11 (1.26, 7.70). CONCLUSIONS: Women born preterm have a more hyperandrogenic hormonal profile, and those born LPT are approximately three times more likely at risk to have PCOS compared to women born at term. |
format |
Text |
author |
Paalanne, Marika Vääräsmäki, Marja Mustaniemi, Sanna Tikanmäki, Marjaana Wehkalampi, Karoliina Matinolli, Hanna-Maria Eriksson, Johan Järvelin, Marjo-Riitta Morin-Papunen, Laure Kajantie, Eero |
author_facet |
Paalanne, Marika Vääräsmäki, Marja Mustaniemi, Sanna Tikanmäki, Marjaana Wehkalampi, Karoliina Matinolli, Hanna-Maria Eriksson, Johan Järvelin, Marjo-Riitta Morin-Papunen, Laure Kajantie, Eero |
author_sort |
Paalanne, Marika |
title |
Clinical and biochemical signs of polycystic ovary syndrome in young women born preterm |
title_short |
Clinical and biochemical signs of polycystic ovary syndrome in young women born preterm |
title_full |
Clinical and biochemical signs of polycystic ovary syndrome in young women born preterm |
title_fullStr |
Clinical and biochemical signs of polycystic ovary syndrome in young women born preterm |
title_full_unstemmed |
Clinical and biochemical signs of polycystic ovary syndrome in young women born preterm |
title_sort |
clinical and biochemical signs of polycystic ovary syndrome in young women born preterm |
publisher |
Bioscientifica Ltd |
publishDate |
2021 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8284903/ http://www.ncbi.nlm.nih.gov/pubmed/34081616 https://doi.org/10.1530/EJE-20-1462 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_source |
Eur J Endocrinol |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8284903/ http://www.ncbi.nlm.nih.gov/pubmed/34081616 http://dx.doi.org/10.1530/EJE-20-1462 |
op_rights |
© The authors https://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) . |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1530/EJE-20-1462 |
container_title |
European Journal of Endocrinology |
container_volume |
185 |
container_issue |
2 |
container_start_page |
279 |
op_container_end_page |
288 |
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1766144185808715776 |