Genetics of canine subvalvular aortic stenosis (SAS)
Subvalvular aortic stenosis (SAS) is one of the most common congenital heart defects of dogs. The disease is characterized by obstruction of the left ventricular outflow tract, resulting in pressure overload on the left ventricle. The etiology of obstruction is a fibromuscular nodule, ridge, or ring...
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ftpubmed:oai:pubmedcentral.nih.gov:8103588 2023-05-15T17:22:06+02:00 Genetics of canine subvalvular aortic stenosis (SAS) Ontiveros, Eric S. Stern, Joshua A. 2021-05-07 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8103588/ http://www.ncbi.nlm.nih.gov/pubmed/33962679 https://doi.org/10.1186/s40575-021-00103-4 en eng BioMed Central http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8103588/ http://www.ncbi.nlm.nih.gov/pubmed/33962679 http://dx.doi.org/10.1186/s40575-021-00103-4 © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. CC0 PDM CC-BY Canine Med Genet Review Text 2021 ftpubmed https://doi.org/10.1186/s40575-021-00103-4 2021-05-16T00:36:19Z Subvalvular aortic stenosis (SAS) is one of the most common congenital heart defects of dogs. The disease is characterized by obstruction of the left ventricular outflow tract, resulting in pressure overload on the left ventricle. The etiology of obstruction is a fibromuscular nodule, ridge, or ring of tissue that increases aortic outflow tract velocity. This review is focused on the prevalence, inheritance pattern, and current genetic insights of canine SAS. The prevalence of this disease was reported at 4.7 % in a large veterinary referral hospital. The mode of inheritance for this disease has also been described in breeds with a high disease prevalence such as the Bullmastiff, Bouvier des Flandres, Dogue de Bordeaux, Golden Retriever, Newfoundland, and Rottweiler. Genetic investigations seeking to identify causative mutations for SAS are lacking with only a single published variant associated with SAS in Newfoundlands. Text Newfoundland PubMed Central (PMC) Bouvier ENVELOPE(-68.133,-68.133,-67.233,-67.233) Flandres ENVELOPE(-63.417,-63.417,-65.033,-65.033) Canine Medicine and Genetics 8 1 |
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Review Ontiveros, Eric S. Stern, Joshua A. Genetics of canine subvalvular aortic stenosis (SAS) |
topic_facet |
Review |
description |
Subvalvular aortic stenosis (SAS) is one of the most common congenital heart defects of dogs. The disease is characterized by obstruction of the left ventricular outflow tract, resulting in pressure overload on the left ventricle. The etiology of obstruction is a fibromuscular nodule, ridge, or ring of tissue that increases aortic outflow tract velocity. This review is focused on the prevalence, inheritance pattern, and current genetic insights of canine SAS. The prevalence of this disease was reported at 4.7 % in a large veterinary referral hospital. The mode of inheritance for this disease has also been described in breeds with a high disease prevalence such as the Bullmastiff, Bouvier des Flandres, Dogue de Bordeaux, Golden Retriever, Newfoundland, and Rottweiler. Genetic investigations seeking to identify causative mutations for SAS are lacking with only a single published variant associated with SAS in Newfoundlands. |
format |
Text |
author |
Ontiveros, Eric S. Stern, Joshua A. |
author_facet |
Ontiveros, Eric S. Stern, Joshua A. |
author_sort |
Ontiveros, Eric S. |
title |
Genetics of canine subvalvular aortic stenosis (SAS) |
title_short |
Genetics of canine subvalvular aortic stenosis (SAS) |
title_full |
Genetics of canine subvalvular aortic stenosis (SAS) |
title_fullStr |
Genetics of canine subvalvular aortic stenosis (SAS) |
title_full_unstemmed |
Genetics of canine subvalvular aortic stenosis (SAS) |
title_sort |
genetics of canine subvalvular aortic stenosis (sas) |
publisher |
BioMed Central |
publishDate |
2021 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8103588/ http://www.ncbi.nlm.nih.gov/pubmed/33962679 https://doi.org/10.1186/s40575-021-00103-4 |
long_lat |
ENVELOPE(-68.133,-68.133,-67.233,-67.233) ENVELOPE(-63.417,-63.417,-65.033,-65.033) |
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Bouvier Flandres |
geographic_facet |
Bouvier Flandres |
genre |
Newfoundland |
genre_facet |
Newfoundland |
op_source |
Canine Med Genet |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8103588/ http://www.ncbi.nlm.nih.gov/pubmed/33962679 http://dx.doi.org/10.1186/s40575-021-00103-4 |
op_rights |
© The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
op_rightsnorm |
CC0 PDM CC-BY |
op_doi |
https://doi.org/10.1186/s40575-021-00103-4 |
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Canine Medicine and Genetics |
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8 |
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