Vitamin C for preventing and treating the common cold
BACKGROUND: Vitamin C (ascorbic acid) for preventing and treating the common cold has been a subject of controversy for 70 years. OBJECTIVES: To find out whether vitamin C reduces the incidence, the duration or severity of the common cold when used either as a continuous regular supplementation ever...
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Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8078152/ http://www.ncbi.nlm.nih.gov/pubmed/23440782 https://doi.org/10.1002/14651858.CD000980.pub4 |
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ftpubmed:oai:pubmedcentral.nih.gov:8078152 2023-05-15T18:28:38+02:00 Vitamin C for preventing and treating the common cold Hemilä, Harri Chalker, Elizabeth 2013-01-31 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8078152/ http://www.ncbi.nlm.nih.gov/pubmed/23440782 https://doi.org/10.1002/14651858.CD000980.pub4 en eng John Wiley & Sons, Ltd http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8078152/ http://www.ncbi.nlm.nih.gov/pubmed/23440782 http://dx.doi.org/10.1002/14651858.CD000980.pub4 Copyright © 2013 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. Cochrane Database Syst Rev Text 2013 ftpubmed https://doi.org/10.1002/14651858.CD000980.pub4 2021-05-16T00:24:43Z BACKGROUND: Vitamin C (ascorbic acid) for preventing and treating the common cold has been a subject of controversy for 70 years. OBJECTIVES: To find out whether vitamin C reduces the incidence, the duration or severity of the common cold when used either as a continuous regular supplementation every day or as a therapy at the onset of cold symptoms. SEARCH METHODS: We searched CENTRAL 2012, Issue 11, MEDLINE (1966 to November week 3, 2012), EMBASE (1990 to November 2012), CINAHL (January 2010 to November 2012), LILACS (January 2010 to November 2012) and Web of Science (January 2010 to November 2012). We also searched the U.S. National Institutes of Health trials register and WHO ICTRP on 29 November 2012. SELECTION CRITERIA: We excluded trials which used less than 0.2 g per day of vitamin C and trials without a placebo comparison. We restricted our review to placebo‐controlled trials. DATA COLLECTION AND ANALYSIS: Two review authors independently extracted data. We assessed 'incidence' of colds during regular supplementation as the proportion of participants experiencing one or more colds during the study period. 'Duration' was the mean number of days of illness of cold episodes. MAIN RESULTS: Twenty‐nine trial comparisons involving 11,306 participants contributed to the meta‐analysis on the risk ratio (RR) of developing a cold whilst taking vitamin C regularly over the study period. In the general community trials involving 10,708 participants, the pooled RR was 0.97 (95% confidence interval (CI) 0.94 to 1.00). Five trials involving a total of 598 marathon runners, skiers and soldiers on subarctic exercises yielded a pooled RR of 0.48 (95% CI 0.35 to 0.64). Thirty‐one comparisons examined the effect of regular vitamin C on common cold duration (9745 episodes). In adults the duration of colds was reduced by 8% (3% to 12%) and in children by 14% (7% to 21%). In children, 1 to 2 g/day vitamin C shortened colds by 18%. The severity of colds was also reduced by regular vitamin C administration. Seven comparisons ... Text Subarctic PubMed Central (PMC) Cochrane Database of Systematic Reviews |
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description |
BACKGROUND: Vitamin C (ascorbic acid) for preventing and treating the common cold has been a subject of controversy for 70 years. OBJECTIVES: To find out whether vitamin C reduces the incidence, the duration or severity of the common cold when used either as a continuous regular supplementation every day or as a therapy at the onset of cold symptoms. SEARCH METHODS: We searched CENTRAL 2012, Issue 11, MEDLINE (1966 to November week 3, 2012), EMBASE (1990 to November 2012), CINAHL (January 2010 to November 2012), LILACS (January 2010 to November 2012) and Web of Science (January 2010 to November 2012). We also searched the U.S. National Institutes of Health trials register and WHO ICTRP on 29 November 2012. SELECTION CRITERIA: We excluded trials which used less than 0.2 g per day of vitamin C and trials without a placebo comparison. We restricted our review to placebo‐controlled trials. DATA COLLECTION AND ANALYSIS: Two review authors independently extracted data. We assessed 'incidence' of colds during regular supplementation as the proportion of participants experiencing one or more colds during the study period. 'Duration' was the mean number of days of illness of cold episodes. MAIN RESULTS: Twenty‐nine trial comparisons involving 11,306 participants contributed to the meta‐analysis on the risk ratio (RR) of developing a cold whilst taking vitamin C regularly over the study period. In the general community trials involving 10,708 participants, the pooled RR was 0.97 (95% confidence interval (CI) 0.94 to 1.00). Five trials involving a total of 598 marathon runners, skiers and soldiers on subarctic exercises yielded a pooled RR of 0.48 (95% CI 0.35 to 0.64). Thirty‐one comparisons examined the effect of regular vitamin C on common cold duration (9745 episodes). In adults the duration of colds was reduced by 8% (3% to 12%) and in children by 14% (7% to 21%). In children, 1 to 2 g/day vitamin C shortened colds by 18%. The severity of colds was also reduced by regular vitamin C administration. Seven comparisons ... |
format |
Text |
author |
Hemilä, Harri Chalker, Elizabeth |
spellingShingle |
Hemilä, Harri Chalker, Elizabeth Vitamin C for preventing and treating the common cold |
author_facet |
Hemilä, Harri Chalker, Elizabeth |
author_sort |
Hemilä, Harri |
title |
Vitamin C for preventing and treating the common cold |
title_short |
Vitamin C for preventing and treating the common cold |
title_full |
Vitamin C for preventing and treating the common cold |
title_fullStr |
Vitamin C for preventing and treating the common cold |
title_full_unstemmed |
Vitamin C for preventing and treating the common cold |
title_sort |
vitamin c for preventing and treating the common cold |
publisher |
John Wiley & Sons, Ltd |
publishDate |
2013 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8078152/ http://www.ncbi.nlm.nih.gov/pubmed/23440782 https://doi.org/10.1002/14651858.CD000980.pub4 |
genre |
Subarctic |
genre_facet |
Subarctic |
op_source |
Cochrane Database Syst Rev |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8078152/ http://www.ncbi.nlm.nih.gov/pubmed/23440782 http://dx.doi.org/10.1002/14651858.CD000980.pub4 |
op_rights |
Copyright © 2013 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. |
op_doi |
https://doi.org/10.1002/14651858.CD000980.pub4 |
container_title |
Cochrane Database of Systematic Reviews |
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1766211171665313792 |