Assessing evidence for adaptive evolution in two hearing-related genes important for high-frequency hearing in echolocating mammals
High-frequency hearing is particularly important for echolocating bats and toothed whales. Previously, studies of the hearing-related genes Prestin, KCNQ4, and TMC1 documented that adaptive evolution of high-frequency hearing has taken place in echolocating bats and toothed whales. In this study, we...
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ftpubmed:oai:pubmedcentral.nih.gov:8049434 2023-05-15T18:33:28+02:00 Assessing evidence for adaptive evolution in two hearing-related genes important for high-frequency hearing in echolocating mammals Wang, Hui Zhao, Hanbo Chu, Yujia Feng, Jiang Sun, Keping 2021-01-30 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8049434/ http://www.ncbi.nlm.nih.gov/pubmed/33784395 https://doi.org/10.1093/g3journal/jkab069 en eng Oxford University Press http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8049434/ http://www.ncbi.nlm.nih.gov/pubmed/33784395 http://dx.doi.org/10.1093/g3journal/jkab069 © The Author(s) 2021. Published by Oxford University Press on behalf of Genetics Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. CC-BY G3 (Bethesda) Investigation Text 2021 ftpubmed https://doi.org/10.1093/g3journal/jkab069 2021-04-25T00:29:46Z High-frequency hearing is particularly important for echolocating bats and toothed whales. Previously, studies of the hearing-related genes Prestin, KCNQ4, and TMC1 documented that adaptive evolution of high-frequency hearing has taken place in echolocating bats and toothed whales. In this study, we present two additional candidate hearing-related genes, Shh and SK2, that may also have contributed to the evolution of echolocation in mammals. Shh is a member of the vertebrate Hedgehog gene family and is required in the specification of the mammalian cochlea. SK2 is expressed in both inner and outer hair cells, and it plays an important role in the auditory system. The coding region sequences of Shh and SK2 were obtained from a wide range of mammals with and without echolocating ability. The topologies of phylogenetic trees constructed using Shh and SK2 were different; however, multiple molecular evolutionary analyses showed that those two genes experienced different selective pressures in echolocating bats and toothed whales compared to nonecholocating mammals. In addition, several nominally significant positively selected sites were detected in the nonfunctional domain of the SK2 gene, indicating that different selective pressures were acting on different parts of the SK2 gene. This study has expanded our knowledge of the adaptive evolution of high-frequency hearing in echolocating mammals. Text toothed whales PubMed Central (PMC) G3 Genes|Genomes|Genetics 11 4 |
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Investigation Wang, Hui Zhao, Hanbo Chu, Yujia Feng, Jiang Sun, Keping Assessing evidence for adaptive evolution in two hearing-related genes important for high-frequency hearing in echolocating mammals |
topic_facet |
Investigation |
description |
High-frequency hearing is particularly important for echolocating bats and toothed whales. Previously, studies of the hearing-related genes Prestin, KCNQ4, and TMC1 documented that adaptive evolution of high-frequency hearing has taken place in echolocating bats and toothed whales. In this study, we present two additional candidate hearing-related genes, Shh and SK2, that may also have contributed to the evolution of echolocation in mammals. Shh is a member of the vertebrate Hedgehog gene family and is required in the specification of the mammalian cochlea. SK2 is expressed in both inner and outer hair cells, and it plays an important role in the auditory system. The coding region sequences of Shh and SK2 were obtained from a wide range of mammals with and without echolocating ability. The topologies of phylogenetic trees constructed using Shh and SK2 were different; however, multiple molecular evolutionary analyses showed that those two genes experienced different selective pressures in echolocating bats and toothed whales compared to nonecholocating mammals. In addition, several nominally significant positively selected sites were detected in the nonfunctional domain of the SK2 gene, indicating that different selective pressures were acting on different parts of the SK2 gene. This study has expanded our knowledge of the adaptive evolution of high-frequency hearing in echolocating mammals. |
format |
Text |
author |
Wang, Hui Zhao, Hanbo Chu, Yujia Feng, Jiang Sun, Keping |
author_facet |
Wang, Hui Zhao, Hanbo Chu, Yujia Feng, Jiang Sun, Keping |
author_sort |
Wang, Hui |
title |
Assessing evidence for adaptive evolution in two hearing-related genes important for high-frequency hearing in echolocating mammals |
title_short |
Assessing evidence for adaptive evolution in two hearing-related genes important for high-frequency hearing in echolocating mammals |
title_full |
Assessing evidence for adaptive evolution in two hearing-related genes important for high-frequency hearing in echolocating mammals |
title_fullStr |
Assessing evidence for adaptive evolution in two hearing-related genes important for high-frequency hearing in echolocating mammals |
title_full_unstemmed |
Assessing evidence for adaptive evolution in two hearing-related genes important for high-frequency hearing in echolocating mammals |
title_sort |
assessing evidence for adaptive evolution in two hearing-related genes important for high-frequency hearing in echolocating mammals |
publisher |
Oxford University Press |
publishDate |
2021 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8049434/ http://www.ncbi.nlm.nih.gov/pubmed/33784395 https://doi.org/10.1093/g3journal/jkab069 |
genre |
toothed whales |
genre_facet |
toothed whales |
op_source |
G3 (Bethesda) |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8049434/ http://www.ncbi.nlm.nih.gov/pubmed/33784395 http://dx.doi.org/10.1093/g3journal/jkab069 |
op_rights |
© The Author(s) 2021. Published by Oxford University Press on behalf of Genetics Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1093/g3journal/jkab069 |
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