Transplacental Respiratory Syncytial Virus and Influenza Virus Antibody Transfer in Alaska Native and Seattle Mother–Infant Pairs
BACKGROUND: Alaska Native (AN) infants are at risk for severe disease due to respiratory syncytial virus (RSV) and influenza. Maternal immunization protects young infants through transplacental antibody transfer. RSV- and influenza-specific transplacental antibody transfer in mother–infant pairs has...
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ftpubmed:oai:pubmedcentral.nih.gov:8023314 2023-05-15T17:05:40+02:00 Transplacental Respiratory Syncytial Virus and Influenza Virus Antibody Transfer in Alaska Native and Seattle Mother–Infant Pairs Chu, Helen Y Newman, Kira L Englund, Janet A Cho, Shari Bull, Catherine Lacombe, Kirsten Carlin, Kristen Bulkow, Lisa R Rudolph, Karen DeByle, Carolynn Berner, James Klejka, Joseph Singleton, Rosalyn 2020-05-05 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8023314/ http://www.ncbi.nlm.nih.gov/pubmed/32369172 https://doi.org/10.1093/jpids/piaa040 en eng Oxford University Press http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8023314/ http://www.ncbi.nlm.nih.gov/pubmed/32369172 http://dx.doi.org/10.1093/jpids/piaa040 © The Author(s) 2020. Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) J Pediatric Infect Dis Soc Original Articles Text 2020 ftpubmed https://doi.org/10.1093/jpids/piaa040 2021-05-09T00:25:18Z BACKGROUND: Alaska Native (AN) infants are at risk for severe disease due to respiratory syncytial virus (RSV) and influenza. Maternal immunization protects young infants through transplacental antibody transfer. RSV- and influenza-specific transplacental antibody transfer in mother–infant pairs has not previously been evaluated in the AN population. METHODS: Serum samples collected during pregnancy and at birth from AN mother–infant pairs in the Yukon-Kuskokwim Delta region (YKD) of Alaska (2000–2011; n = 75) and predominantly white pairs in Seattle, Washington (2014–2016; n = 57), were tested for RSV and influenza antibody using a microneutralization and hemagglutination inhibition assay, respectively, and compared between sites. RESULTS: Mean RSV antibody concentrations in pregnant women in YKD and Seattle were similar (log(2) RSV antibody 10.6 vs 10.7, P = .86), but cord blood RSV antibody concentrations were significantly lower in infants born to mothers in YKD compared with Seattle (log(2) RSV antibody 11.0 vs 12.2, P < .001). Maternal and cord blood influenza antibody concentrations were lower for women and infants in YKD compared with Seattle for all 4 influenza antigens tested (all P < .05). The mean cord to maternal RSV antibody transfer ratio was 1.15 (standard deviation [SD], 0.13) in mother–infant pairs in Seattle compared with 1.04 (SD, 0.08) in YKD. Mean cord blood to maternal antibody transfer ratios for influenza antigens ranged from 1.22 to 1.42 in Seattle and from 1.05 to 1.59 in YKD. CONCLUSIONS: Though the transplacental antibody transfer ratio was high (>1.0) for both groups, transfer ratios for RSV antibody were significantly lower in AN mother–infant pairs. Further studies are needed to elucidate the impact of lower transplacental antibody transfer on infant disease risk in rural Alaska. Alaska Native and continental US mother-infant pairs have high transplacental antibody transfer ratios (>1.0) for influenza and respiratory syncytial virus, but anti-respiratory syncytial ... Text Kuskokwim Alaska Yukon PubMed Central (PMC) Yukon Journal of the Pediatric Infectious Diseases Society 10 3 230 236 |
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Original Articles Chu, Helen Y Newman, Kira L Englund, Janet A Cho, Shari Bull, Catherine Lacombe, Kirsten Carlin, Kristen Bulkow, Lisa R Rudolph, Karen DeByle, Carolynn Berner, James Klejka, Joseph Singleton, Rosalyn Transplacental Respiratory Syncytial Virus and Influenza Virus Antibody Transfer in Alaska Native and Seattle Mother–Infant Pairs |
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Original Articles |
description |
BACKGROUND: Alaska Native (AN) infants are at risk for severe disease due to respiratory syncytial virus (RSV) and influenza. Maternal immunization protects young infants through transplacental antibody transfer. RSV- and influenza-specific transplacental antibody transfer in mother–infant pairs has not previously been evaluated in the AN population. METHODS: Serum samples collected during pregnancy and at birth from AN mother–infant pairs in the Yukon-Kuskokwim Delta region (YKD) of Alaska (2000–2011; n = 75) and predominantly white pairs in Seattle, Washington (2014–2016; n = 57), were tested for RSV and influenza antibody using a microneutralization and hemagglutination inhibition assay, respectively, and compared between sites. RESULTS: Mean RSV antibody concentrations in pregnant women in YKD and Seattle were similar (log(2) RSV antibody 10.6 vs 10.7, P = .86), but cord blood RSV antibody concentrations were significantly lower in infants born to mothers in YKD compared with Seattle (log(2) RSV antibody 11.0 vs 12.2, P < .001). Maternal and cord blood influenza antibody concentrations were lower for women and infants in YKD compared with Seattle for all 4 influenza antigens tested (all P < .05). The mean cord to maternal RSV antibody transfer ratio was 1.15 (standard deviation [SD], 0.13) in mother–infant pairs in Seattle compared with 1.04 (SD, 0.08) in YKD. Mean cord blood to maternal antibody transfer ratios for influenza antigens ranged from 1.22 to 1.42 in Seattle and from 1.05 to 1.59 in YKD. CONCLUSIONS: Though the transplacental antibody transfer ratio was high (>1.0) for both groups, transfer ratios for RSV antibody were significantly lower in AN mother–infant pairs. Further studies are needed to elucidate the impact of lower transplacental antibody transfer on infant disease risk in rural Alaska. Alaska Native and continental US mother-infant pairs have high transplacental antibody transfer ratios (>1.0) for influenza and respiratory syncytial virus, but anti-respiratory syncytial ... |
format |
Text |
author |
Chu, Helen Y Newman, Kira L Englund, Janet A Cho, Shari Bull, Catherine Lacombe, Kirsten Carlin, Kristen Bulkow, Lisa R Rudolph, Karen DeByle, Carolynn Berner, James Klejka, Joseph Singleton, Rosalyn |
author_facet |
Chu, Helen Y Newman, Kira L Englund, Janet A Cho, Shari Bull, Catherine Lacombe, Kirsten Carlin, Kristen Bulkow, Lisa R Rudolph, Karen DeByle, Carolynn Berner, James Klejka, Joseph Singleton, Rosalyn |
author_sort |
Chu, Helen Y |
title |
Transplacental Respiratory Syncytial Virus and Influenza Virus Antibody Transfer in Alaska Native and Seattle Mother–Infant Pairs |
title_short |
Transplacental Respiratory Syncytial Virus and Influenza Virus Antibody Transfer in Alaska Native and Seattle Mother–Infant Pairs |
title_full |
Transplacental Respiratory Syncytial Virus and Influenza Virus Antibody Transfer in Alaska Native and Seattle Mother–Infant Pairs |
title_fullStr |
Transplacental Respiratory Syncytial Virus and Influenza Virus Antibody Transfer in Alaska Native and Seattle Mother–Infant Pairs |
title_full_unstemmed |
Transplacental Respiratory Syncytial Virus and Influenza Virus Antibody Transfer in Alaska Native and Seattle Mother–Infant Pairs |
title_sort |
transplacental respiratory syncytial virus and influenza virus antibody transfer in alaska native and seattle mother–infant pairs |
publisher |
Oxford University Press |
publishDate |
2020 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8023314/ http://www.ncbi.nlm.nih.gov/pubmed/32369172 https://doi.org/10.1093/jpids/piaa040 |
geographic |
Yukon |
geographic_facet |
Yukon |
genre |
Kuskokwim Alaska Yukon |
genre_facet |
Kuskokwim Alaska Yukon |
op_source |
J Pediatric Infect Dis Soc |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8023314/ http://www.ncbi.nlm.nih.gov/pubmed/32369172 http://dx.doi.org/10.1093/jpids/piaa040 |
op_rights |
© The Author(s) 2020. Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) |
op_doi |
https://doi.org/10.1093/jpids/piaa040 |
container_title |
Journal of the Pediatric Infectious Diseases Society |
container_volume |
10 |
container_issue |
3 |
container_start_page |
230 |
op_container_end_page |
236 |
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1766060368673636352 |