Vitamin D status and association with gestational diabetes mellitus in a pregnant cohort in Iceland
BACKGROUND: Vitamin D deficiency has been associated with an increased risk of gestational diabetes mellitus (GDM), one of the most common pregnancy complications. The vitamin D status has never previously been studied in pregnant women in Iceland. OBJECTIVE: The aim of this research study was to ev...
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ftpubmed:oai:pubmedcentral.nih.gov:8009083 2023-05-15T16:49:09+02:00 Vitamin D status and association with gestational diabetes mellitus in a pregnant cohort in Iceland Magnusdottir, Kristin S. Tryggvadottir, Ellen A. Magnusdottir, Ola K. Hrolfsdottir, Laufey Halldorsson, Thorhallur I. Birgisdottir, Bryndis E. Hreidarsdottir, Ingibjorg T. Hardardottir, Hildur Gunnarsdottir, Ingibjorg 2021-03-23 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8009083/ https://doi.org/10.29219/fnr.v65.5574 en eng Open Academia http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8009083/ http://dx.doi.org/10.29219/fnr.v65.5574 © 2021 Magnusdottir et al. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material for any purpose, even commercially, provided the original work is properly cited and states its license. CC-BY Food Nutr Res Original Article Text 2021 ftpubmed https://doi.org/10.29219/fnr.v65.5574 2021-04-11T00:25:40Z BACKGROUND: Vitamin D deficiency has been associated with an increased risk of gestational diabetes mellitus (GDM), one of the most common pregnancy complications. The vitamin D status has never previously been studied in pregnant women in Iceland. OBJECTIVE: The aim of this research study was to evaluate the vitamin D status of an Icelandic cohort of pregnant women and the association between the vitamin D status and the GDM incidence. DESIGN: Subjects included pregnant women (n = 938) who attended their first ultrasound appointment, during gestational weeks 11–14, between October 2017 and March 2018. The use of supplements containing vitamin D over the previous 3 months, height, pre-pregnancy weight, and social status were assessed using a questionnaire, and blood samples were drawn for analyzing the serum 25‑hydroxyvitamin D (25OHD) concentration. Information regarding the incidence of GDM later in pregnancy was collected from medical records. RESULTS: The mean ± standard deviation of the serum 25OHD (S-25OHD) concentration in this cohort was 63±24 nmol/L. The proportion of women with an S-25OHD concentration of ≥ 50 nmol/L (which is considered adequate) was 70%, whereas 25% had concentrations between 30 and 49.9 nmol/L (insufficient) and 5% had concentrations < 30 nmol/L (deficient). The majority of women (n = 766, 82%) used supplements containing vitamin D on a daily basis. A gradual decrease in the proportion of women diagnosed with GDM was reported with increasing S-25OHD concentrations, going from 17.8% in the group with S-25OHD concentrations < 30 nmol/L to 12.8% in the group with S-25OHD concentrations ≥75 nmol/L; however, the association was not significant (P for trend = 0.11). CONCLUSION: Approximately one-third of this cohort had S-25OHD concentrations below adequate levels (< 50 nmol/L) during the first trimester of pregnancy, which may suggest that necessary action must be taken to increase their vitamin D levels. No clear association was observed between the vitamin D status and GDM in ... Text Iceland PubMed Central (PMC) Food & Nutrition Research 65 |
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Original Article Magnusdottir, Kristin S. Tryggvadottir, Ellen A. Magnusdottir, Ola K. Hrolfsdottir, Laufey Halldorsson, Thorhallur I. Birgisdottir, Bryndis E. Hreidarsdottir, Ingibjorg T. Hardardottir, Hildur Gunnarsdottir, Ingibjorg Vitamin D status and association with gestational diabetes mellitus in a pregnant cohort in Iceland |
topic_facet |
Original Article |
description |
BACKGROUND: Vitamin D deficiency has been associated with an increased risk of gestational diabetes mellitus (GDM), one of the most common pregnancy complications. The vitamin D status has never previously been studied in pregnant women in Iceland. OBJECTIVE: The aim of this research study was to evaluate the vitamin D status of an Icelandic cohort of pregnant women and the association between the vitamin D status and the GDM incidence. DESIGN: Subjects included pregnant women (n = 938) who attended their first ultrasound appointment, during gestational weeks 11–14, between October 2017 and March 2018. The use of supplements containing vitamin D over the previous 3 months, height, pre-pregnancy weight, and social status were assessed using a questionnaire, and blood samples were drawn for analyzing the serum 25‑hydroxyvitamin D (25OHD) concentration. Information regarding the incidence of GDM later in pregnancy was collected from medical records. RESULTS: The mean ± standard deviation of the serum 25OHD (S-25OHD) concentration in this cohort was 63±24 nmol/L. The proportion of women with an S-25OHD concentration of ≥ 50 nmol/L (which is considered adequate) was 70%, whereas 25% had concentrations between 30 and 49.9 nmol/L (insufficient) and 5% had concentrations < 30 nmol/L (deficient). The majority of women (n = 766, 82%) used supplements containing vitamin D on a daily basis. A gradual decrease in the proportion of women diagnosed with GDM was reported with increasing S-25OHD concentrations, going from 17.8% in the group with S-25OHD concentrations < 30 nmol/L to 12.8% in the group with S-25OHD concentrations ≥75 nmol/L; however, the association was not significant (P for trend = 0.11). CONCLUSION: Approximately one-third of this cohort had S-25OHD concentrations below adequate levels (< 50 nmol/L) during the first trimester of pregnancy, which may suggest that necessary action must be taken to increase their vitamin D levels. No clear association was observed between the vitamin D status and GDM in ... |
format |
Text |
author |
Magnusdottir, Kristin S. Tryggvadottir, Ellen A. Magnusdottir, Ola K. Hrolfsdottir, Laufey Halldorsson, Thorhallur I. Birgisdottir, Bryndis E. Hreidarsdottir, Ingibjorg T. Hardardottir, Hildur Gunnarsdottir, Ingibjorg |
author_facet |
Magnusdottir, Kristin S. Tryggvadottir, Ellen A. Magnusdottir, Ola K. Hrolfsdottir, Laufey Halldorsson, Thorhallur I. Birgisdottir, Bryndis E. Hreidarsdottir, Ingibjorg T. Hardardottir, Hildur Gunnarsdottir, Ingibjorg |
author_sort |
Magnusdottir, Kristin S. |
title |
Vitamin D status and association with gestational diabetes mellitus in a pregnant cohort in Iceland |
title_short |
Vitamin D status and association with gestational diabetes mellitus in a pregnant cohort in Iceland |
title_full |
Vitamin D status and association with gestational diabetes mellitus in a pregnant cohort in Iceland |
title_fullStr |
Vitamin D status and association with gestational diabetes mellitus in a pregnant cohort in Iceland |
title_full_unstemmed |
Vitamin D status and association with gestational diabetes mellitus in a pregnant cohort in Iceland |
title_sort |
vitamin d status and association with gestational diabetes mellitus in a pregnant cohort in iceland |
publisher |
Open Academia |
publishDate |
2021 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8009083/ https://doi.org/10.29219/fnr.v65.5574 |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Food Nutr Res |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8009083/ http://dx.doi.org/10.29219/fnr.v65.5574 |
op_rights |
© 2021 Magnusdottir et al. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material for any purpose, even commercially, provided the original work is properly cited and states its license. |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.29219/fnr.v65.5574 |
container_title |
Food & Nutrition Research |
container_volume |
65 |
_version_ |
1766039261978558464 |