An overview of drive systems and sealing types in stirred bioreactors used in biotechnological processes
No matter the scale, stirred tank bioreactors are the most commonly used systems in biotechnological production processes. Single-use and reusable systems are supplied by several manufacturers. The type, size, and number of impellers used in these systems have a significant influence on the characte...
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ftpubmed:oai:pubmedcentral.nih.gov:7954712 2023-05-15T15:56:08+02:00 An overview of drive systems and sealing types in stirred bioreactors used in biotechnological processes Schirmer, Cedric Maschke, Rüdiger W. Pörtner, Ralf Eibl, Dieter 2021-03-02 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7954712/ http://www.ncbi.nlm.nih.gov/pubmed/33649923 https://doi.org/10.1007/s00253-021-11180-7 en eng Springer Berlin Heidelberg http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7954712/ http://www.ncbi.nlm.nih.gov/pubmed/33649923 http://dx.doi.org/10.1007/s00253-021-11180-7 © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. CC-BY Appl Microbiol Biotechnol Mini-Review Text 2021 ftpubmed https://doi.org/10.1007/s00253-021-11180-7 2021-04-04T00:35:46Z No matter the scale, stirred tank bioreactors are the most commonly used systems in biotechnological production processes. Single-use and reusable systems are supplied by several manufacturers. The type, size, and number of impellers used in these systems have a significant influence on the characteristics and designs of bioreactors. Depending on the desired application, classic shaft-driven systems, bearing-mounted drives, or stirring elements that levitate freely in the vessel may be employed. In systems with drive shafts, process hygiene requirements also affect the type of seal used. For sensitive processes with high hygienic requirements, magnetic-driven stirring systems, which have been the focus of much research in recent years, are recommended. This review provides the reader with an overview of the most common agitation and seal types implemented in stirred bioreactor systems, highlights their advantages and disadvantages, and explains their possible fields of application. Special attention is paid to the development of magnetically driven agitators, which are widely used in reusable systems and are also becoming more and more important in their single-use counterparts. Key Points • Basic design of the most frequently used bioreactor type: the stirred tank bioreactor • Differences in most common seal types in stirred systems and fields of application • Comprehensive overview of commercially available bioreactor seal types • Increased use of magnetically driven agitation systems in single-use bioreactors Text common seal PubMed Central (PMC) Applied Microbiology and Biotechnology 105 6 2225 2242 |
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Mini-Review |
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Mini-Review Schirmer, Cedric Maschke, Rüdiger W. Pörtner, Ralf Eibl, Dieter An overview of drive systems and sealing types in stirred bioreactors used in biotechnological processes |
topic_facet |
Mini-Review |
description |
No matter the scale, stirred tank bioreactors are the most commonly used systems in biotechnological production processes. Single-use and reusable systems are supplied by several manufacturers. The type, size, and number of impellers used in these systems have a significant influence on the characteristics and designs of bioreactors. Depending on the desired application, classic shaft-driven systems, bearing-mounted drives, or stirring elements that levitate freely in the vessel may be employed. In systems with drive shafts, process hygiene requirements also affect the type of seal used. For sensitive processes with high hygienic requirements, magnetic-driven stirring systems, which have been the focus of much research in recent years, are recommended. This review provides the reader with an overview of the most common agitation and seal types implemented in stirred bioreactor systems, highlights their advantages and disadvantages, and explains their possible fields of application. Special attention is paid to the development of magnetically driven agitators, which are widely used in reusable systems and are also becoming more and more important in their single-use counterparts. Key Points • Basic design of the most frequently used bioreactor type: the stirred tank bioreactor • Differences in most common seal types in stirred systems and fields of application • Comprehensive overview of commercially available bioreactor seal types • Increased use of magnetically driven agitation systems in single-use bioreactors |
format |
Text |
author |
Schirmer, Cedric Maschke, Rüdiger W. Pörtner, Ralf Eibl, Dieter |
author_facet |
Schirmer, Cedric Maschke, Rüdiger W. Pörtner, Ralf Eibl, Dieter |
author_sort |
Schirmer, Cedric |
title |
An overview of drive systems and sealing types in stirred bioreactors used in biotechnological processes |
title_short |
An overview of drive systems and sealing types in stirred bioreactors used in biotechnological processes |
title_full |
An overview of drive systems and sealing types in stirred bioreactors used in biotechnological processes |
title_fullStr |
An overview of drive systems and sealing types in stirred bioreactors used in biotechnological processes |
title_full_unstemmed |
An overview of drive systems and sealing types in stirred bioreactors used in biotechnological processes |
title_sort |
overview of drive systems and sealing types in stirred bioreactors used in biotechnological processes |
publisher |
Springer Berlin Heidelberg |
publishDate |
2021 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7954712/ http://www.ncbi.nlm.nih.gov/pubmed/33649923 https://doi.org/10.1007/s00253-021-11180-7 |
genre |
common seal |
genre_facet |
common seal |
op_source |
Appl Microbiol Biotechnol |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7954712/ http://www.ncbi.nlm.nih.gov/pubmed/33649923 http://dx.doi.org/10.1007/s00253-021-11180-7 |
op_rights |
© The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1007/s00253-021-11180-7 |
container_title |
Applied Microbiology and Biotechnology |
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105 |
container_issue |
6 |
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2225 |
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2242 |
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