Cyclic Guanosine Monophosphate Modulates Locomotor Acceleration Induced by Nitric Oxide but not Serotonin in Clione limacina Central Pattern Generator Swim Interneurons
Both nitric oxide (NO) and serotonin (5HT) mediate swim acceleration in the marine mollusk, Clione limacina. In this study, we examine the role that the second messenger, cyclic guanosine monophosphate (cGMP), plays in mediating NO and 5HT-induced swim acceleration. We observed that the application...
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Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7884873/ http://www.ncbi.nlm.nih.gov/pubmed/33791588 https://doi.org/10.1093/iob/obaa045 |
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ftpubmed:oai:pubmedcentral.nih.gov:7884873 2023-05-15T15:55:41+02:00 Cyclic Guanosine Monophosphate Modulates Locomotor Acceleration Induced by Nitric Oxide but not Serotonin in Clione limacina Central Pattern Generator Swim Interneurons Pirtle, Thomas J Satterlie, Richard A 2021-01-24 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7884873/ http://www.ncbi.nlm.nih.gov/pubmed/33791588 https://doi.org/10.1093/iob/obaa045 en eng Oxford University Press http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7884873/ http://www.ncbi.nlm.nih.gov/pubmed/33791588 http://dx.doi.org/10.1093/iob/obaa045 © The Author(s) 2021. Published by Oxford University Press on behalf of the Society for Integrative and Comparative Biology. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. CC-BY Integr Org Biol Article Text 2021 ftpubmed https://doi.org/10.1093/iob/obaa045 2021-04-04T00:33:11Z Both nitric oxide (NO) and serotonin (5HT) mediate swim acceleration in the marine mollusk, Clione limacina. In this study, we examine the role that the second messenger, cyclic guanosine monophosphate (cGMP), plays in mediating NO and 5HT-induced swim acceleration. We observed that the application of an analog of cGMP or an activator of soluble guanylyl cyclase (sGC) increased fictive locomotor speed recorded from Pd-7 interneurons of the animal’s locomotor central pattern generator. Moreover, inhibition of sGC decreased fictive locomotor speed. These results suggest that basal levels of cGMP are important for slow swimming and that increased production of cGMP mediates swim acceleration in Clione. Because NO has its effect through cGMP signaling and because we show herein that cGMP produces cellular changes in Clione swim interneurons that are consistent with cellular changes produced by 5HT application, we hypothesize that both NO and 5HT function via a common signal transduction pathway that involves cGMP. Our results show that cGMP mediates NO-induced but not 5HT-induced swim acceleration in Clione. Text Clione limacina PubMed Central (PMC) Integrative Organismal Biology 3 1 |
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Article Pirtle, Thomas J Satterlie, Richard A Cyclic Guanosine Monophosphate Modulates Locomotor Acceleration Induced by Nitric Oxide but not Serotonin in Clione limacina Central Pattern Generator Swim Interneurons |
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description |
Both nitric oxide (NO) and serotonin (5HT) mediate swim acceleration in the marine mollusk, Clione limacina. In this study, we examine the role that the second messenger, cyclic guanosine monophosphate (cGMP), plays in mediating NO and 5HT-induced swim acceleration. We observed that the application of an analog of cGMP or an activator of soluble guanylyl cyclase (sGC) increased fictive locomotor speed recorded from Pd-7 interneurons of the animal’s locomotor central pattern generator. Moreover, inhibition of sGC decreased fictive locomotor speed. These results suggest that basal levels of cGMP are important for slow swimming and that increased production of cGMP mediates swim acceleration in Clione. Because NO has its effect through cGMP signaling and because we show herein that cGMP produces cellular changes in Clione swim interneurons that are consistent with cellular changes produced by 5HT application, we hypothesize that both NO and 5HT function via a common signal transduction pathway that involves cGMP. Our results show that cGMP mediates NO-induced but not 5HT-induced swim acceleration in Clione. |
format |
Text |
author |
Pirtle, Thomas J Satterlie, Richard A |
author_facet |
Pirtle, Thomas J Satterlie, Richard A |
author_sort |
Pirtle, Thomas J |
title |
Cyclic Guanosine Monophosphate Modulates Locomotor Acceleration Induced by Nitric Oxide but not Serotonin in Clione limacina Central Pattern Generator Swim Interneurons |
title_short |
Cyclic Guanosine Monophosphate Modulates Locomotor Acceleration Induced by Nitric Oxide but not Serotonin in Clione limacina Central Pattern Generator Swim Interneurons |
title_full |
Cyclic Guanosine Monophosphate Modulates Locomotor Acceleration Induced by Nitric Oxide but not Serotonin in Clione limacina Central Pattern Generator Swim Interneurons |
title_fullStr |
Cyclic Guanosine Monophosphate Modulates Locomotor Acceleration Induced by Nitric Oxide but not Serotonin in Clione limacina Central Pattern Generator Swim Interneurons |
title_full_unstemmed |
Cyclic Guanosine Monophosphate Modulates Locomotor Acceleration Induced by Nitric Oxide but not Serotonin in Clione limacina Central Pattern Generator Swim Interneurons |
title_sort |
cyclic guanosine monophosphate modulates locomotor acceleration induced by nitric oxide but not serotonin in clione limacina central pattern generator swim interneurons |
publisher |
Oxford University Press |
publishDate |
2021 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7884873/ http://www.ncbi.nlm.nih.gov/pubmed/33791588 https://doi.org/10.1093/iob/obaa045 |
genre |
Clione limacina |
genre_facet |
Clione limacina |
op_source |
Integr Org Biol |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7884873/ http://www.ncbi.nlm.nih.gov/pubmed/33791588 http://dx.doi.org/10.1093/iob/obaa045 |
op_rights |
© The Author(s) 2021. Published by Oxford University Press on behalf of the Society for Integrative and Comparative Biology. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1093/iob/obaa045 |
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Integrative Organismal Biology |
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