Structural analysis of COVID-19 spike protein in recognizing the ACE2 receptor of different mammalian species and its susceptibility to viral infection

• Published in: 3 Biotech
• Main Authors: Koley, Tirthankar, Madaan, Shivani, Chowdhury, Sanghati Roy, Kumar, Manoj, Kaur, Punit, Singh, Tej Pal, Ethayathulla, Abdul S.
• Format: Text
• Language: English
• Published: Springer International Publishing 2021
• Subjects: Original Article; The Spike; Canis lupus; Rattus rattus
• Online Access: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848672/; https://doi.org/10.1007/s13205-020-02599-2

The pandemic COVID-19 was caused by a novel Coronavirus-2 (SARS-CoV-2) that infects humans through the binding of glycosylated SARS-CoV-2 spike 2 protein to the glycosylated ACE2 receptor. The spike 2 protein recognizes the N-terminal helices of the glycosylated metalloprotease domain in the human A...