Antibacterial Properties of Fucoidans from the Brown Algae Fucus vesiculosus L. of the Barents Sea
SIMPLE SUMMARY: The continuous emergence of new pathogenic strains of bacteria resistant to antibiotics highlights the importance of search for the new natural sources of antimicrobial compounds. Fucoidans, sulfated polysaccharides from the cell walls of brown algae, attract the attention of many re...
Published in: | Biology |
---|---|
Main Authors: | , , , , , , |
Format: | Text |
Language: | English |
Published: |
MDPI
2021
|
Subjects: | |
Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7832856/ http://www.ncbi.nlm.nih.gov/pubmed/33477817 https://doi.org/10.3390/biology10010067 |
id |
ftpubmed:oai:pubmedcentral.nih.gov:7832856 |
---|---|
record_format |
openpolar |
spelling |
ftpubmed:oai:pubmedcentral.nih.gov:7832856 2023-05-15T15:38:39+02:00 Antibacterial Properties of Fucoidans from the Brown Algae Fucus vesiculosus L. of the Barents Sea Ayrapetyan, Olga N. Obluchinskaya, Ekaterina D. Zhurishkina, Elena V. Skorik, Yury A. Lebedev, Dmitry V. Kulminskaya, Anna A. Lapina, Irina M. 2021-01-19 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7832856/ http://www.ncbi.nlm.nih.gov/pubmed/33477817 https://doi.org/10.3390/biology10010067 en eng MDPI http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7832856/ http://www.ncbi.nlm.nih.gov/pubmed/33477817 http://dx.doi.org/10.3390/biology10010067 © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). CC-BY Biology (Basel) Article Text 2021 ftpubmed https://doi.org/10.3390/biology10010067 2021-01-31T01:57:53Z SIMPLE SUMMARY: The continuous emergence of new pathogenic strains of bacteria resistant to antibiotics highlights the importance of search for the new natural sources of antimicrobial compounds. Fucoidans, sulfated polysaccharides from the cell walls of brown algae, attract the attention of many researchers due to their wide range of biological activities. Being natural and practically non-toxic, they are considered as a promising antimicrobial component that could, where possible, replace the use of strong chemical antiseptics and modern antibiotics. Natural fucoidans are polydisperse polysaccharides whose composition can vary greatly depending on the species, habitat, as well as on the way of purification. In this work, we investigate the structure and antibacterial properties of fucoidans from the brown algae Fucus vesiculosus gathered in the littoral of the Barents Sea. These fucoidans appear to have a significant bacteriostatic effect on the growth of four tested bacterial strains. Such an effect was more pronounced for crude fucoidan samples that did not undergo additional steps of purification. ABSTRACT: Fucoidans, sulfated polysaccharides found in cell walls of brown algae, are considered as a promising antimicrobial component for various applications in medicine and the food industry. In this study, we compare the antibacterial properties of two fractions of fucoidan from the brown algae Fucus vesiculosus gathered in the littoral of the Barents Sea and sampled at different stages of purification. The crude fraction of fucoidan was isolated from algae by extraction with aqueous ethanol and sonication. The purified fraction was obtained by additional treatment of the crude fraction with a solution of calcium chloride. The structural features of both fractions were characterized in detail and their antibacterial effects against several Gram-positive and Gram-negative bacteria were compared by photometry, acridine orange staining assay, and atomic force microscopy. Fucoidan inhibited growth in all of the ... Text Barents Sea PubMed Central (PMC) Barents Sea Biology 10 1 67 |
institution |
Open Polar |
collection |
PubMed Central (PMC) |
op_collection_id |
ftpubmed |
language |
English |
topic |
Article |
spellingShingle |
Article Ayrapetyan, Olga N. Obluchinskaya, Ekaterina D. Zhurishkina, Elena V. Skorik, Yury A. Lebedev, Dmitry V. Kulminskaya, Anna A. Lapina, Irina M. Antibacterial Properties of Fucoidans from the Brown Algae Fucus vesiculosus L. of the Barents Sea |
topic_facet |
Article |
description |
SIMPLE SUMMARY: The continuous emergence of new pathogenic strains of bacteria resistant to antibiotics highlights the importance of search for the new natural sources of antimicrobial compounds. Fucoidans, sulfated polysaccharides from the cell walls of brown algae, attract the attention of many researchers due to their wide range of biological activities. Being natural and practically non-toxic, they are considered as a promising antimicrobial component that could, where possible, replace the use of strong chemical antiseptics and modern antibiotics. Natural fucoidans are polydisperse polysaccharides whose composition can vary greatly depending on the species, habitat, as well as on the way of purification. In this work, we investigate the structure and antibacterial properties of fucoidans from the brown algae Fucus vesiculosus gathered in the littoral of the Barents Sea. These fucoidans appear to have a significant bacteriostatic effect on the growth of four tested bacterial strains. Such an effect was more pronounced for crude fucoidan samples that did not undergo additional steps of purification. ABSTRACT: Fucoidans, sulfated polysaccharides found in cell walls of brown algae, are considered as a promising antimicrobial component for various applications in medicine and the food industry. In this study, we compare the antibacterial properties of two fractions of fucoidan from the brown algae Fucus vesiculosus gathered in the littoral of the Barents Sea and sampled at different stages of purification. The crude fraction of fucoidan was isolated from algae by extraction with aqueous ethanol and sonication. The purified fraction was obtained by additional treatment of the crude fraction with a solution of calcium chloride. The structural features of both fractions were characterized in detail and their antibacterial effects against several Gram-positive and Gram-negative bacteria were compared by photometry, acridine orange staining assay, and atomic force microscopy. Fucoidan inhibited growth in all of the ... |
format |
Text |
author |
Ayrapetyan, Olga N. Obluchinskaya, Ekaterina D. Zhurishkina, Elena V. Skorik, Yury A. Lebedev, Dmitry V. Kulminskaya, Anna A. Lapina, Irina M. |
author_facet |
Ayrapetyan, Olga N. Obluchinskaya, Ekaterina D. Zhurishkina, Elena V. Skorik, Yury A. Lebedev, Dmitry V. Kulminskaya, Anna A. Lapina, Irina M. |
author_sort |
Ayrapetyan, Olga N. |
title |
Antibacterial Properties of Fucoidans from the Brown Algae Fucus vesiculosus L. of the Barents Sea |
title_short |
Antibacterial Properties of Fucoidans from the Brown Algae Fucus vesiculosus L. of the Barents Sea |
title_full |
Antibacterial Properties of Fucoidans from the Brown Algae Fucus vesiculosus L. of the Barents Sea |
title_fullStr |
Antibacterial Properties of Fucoidans from the Brown Algae Fucus vesiculosus L. of the Barents Sea |
title_full_unstemmed |
Antibacterial Properties of Fucoidans from the Brown Algae Fucus vesiculosus L. of the Barents Sea |
title_sort |
antibacterial properties of fucoidans from the brown algae fucus vesiculosus l. of the barents sea |
publisher |
MDPI |
publishDate |
2021 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7832856/ http://www.ncbi.nlm.nih.gov/pubmed/33477817 https://doi.org/10.3390/biology10010067 |
geographic |
Barents Sea |
geographic_facet |
Barents Sea |
genre |
Barents Sea |
genre_facet |
Barents Sea |
op_source |
Biology (Basel) |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7832856/ http://www.ncbi.nlm.nih.gov/pubmed/33477817 http://dx.doi.org/10.3390/biology10010067 |
op_rights |
© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.3390/biology10010067 |
container_title |
Biology |
container_volume |
10 |
container_issue |
1 |
container_start_page |
67 |
_version_ |
1766369864784543744 |