Serum alanine aminotransferase activity and risk factors for cardiovascular disease in a Caucasian population: the Tromsø study
BACKGROUND: High and low levels of serum alanine aminotransferase (ALT) are both associated with cardiovascular diseases (CVD) risks especially in elderly, but the mechanisms are less known. This study investigated associations between ALT and CVD risk factors including effects of sex and age in a C...
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ftpubmed:oai:pubmedcentral.nih.gov:7805181 2023-05-15T18:34:26+02:00 Serum alanine aminotransferase activity and risk factors for cardiovascular disease in a Caucasian population: the Tromsø study Bekkelund, Svein Ivar 2021-01-13 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7805181/ https://doi.org/10.1186/s12872-020-01826-1 en eng BioMed Central http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7805181/ http://dx.doi.org/10.1186/s12872-020-01826-1 © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. CC0 PDM CC-BY BMC Cardiovasc Disord Research Article Text 2021 ftpubmed https://doi.org/10.1186/s12872-020-01826-1 2021-01-17T01:49:40Z BACKGROUND: High and low levels of serum alanine aminotransferase (ALT) are both associated with cardiovascular diseases (CVD) risks especially in elderly, but the mechanisms are less known. This study investigated associations between ALT and CVD risk factors including effects of sex and age in a Caucasian population. METHODS: Cross-sectional data were analysed sex-stratified in 2555 men (mean age 60.4 years) and 2858 women (mean age 60.0 years) from the population study Tromsø 6. Associations were assessed by variance analysis and multivariable logistic regression of odds to have abnormal ALT. Risk factors included body mass index (BMI), waist-to-hip-ratio, blood pressure, lipids, glucose, glycated haemoglobin and high-sensitive C-reactive protein (CRP). RESULTS: Abnormal elevated ALT was detected in 113 men (4.4%) and 188 women (6.6%). Most CVD risk factors associated positively with ALT in both sexes except systolic blood pressure and CRP (women only), while ALT was positively associated with age in men when adjusted for CVD risk factors, P < 0.001. BMI predicted ALT in men (OR 0.94; 95% CI 0.88–1.00, P = 0.047) and women (OR 0.90; 95% CI 0.86–0.95, P < 0.001). A linear inversed association between age and ALT in men and a non-linear inversed U-trend in women with maximum level between 60 and 64 years were found. CONCLUSION: This study confirms a positive relationship between ALT and CVD risk factors, particularly BMI. Age is not a major confounder in the ALT-CVD relationship, but separate sex-analyses is recommended in such studies. Text Tromsø PubMed Central (PMC) Tromsø BMC Cardiovascular Disorders 21 1 |
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Research Article Bekkelund, Svein Ivar Serum alanine aminotransferase activity and risk factors for cardiovascular disease in a Caucasian population: the Tromsø study |
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Research Article |
description |
BACKGROUND: High and low levels of serum alanine aminotransferase (ALT) are both associated with cardiovascular diseases (CVD) risks especially in elderly, but the mechanisms are less known. This study investigated associations between ALT and CVD risk factors including effects of sex and age in a Caucasian population. METHODS: Cross-sectional data were analysed sex-stratified in 2555 men (mean age 60.4 years) and 2858 women (mean age 60.0 years) from the population study Tromsø 6. Associations were assessed by variance analysis and multivariable logistic regression of odds to have abnormal ALT. Risk factors included body mass index (BMI), waist-to-hip-ratio, blood pressure, lipids, glucose, glycated haemoglobin and high-sensitive C-reactive protein (CRP). RESULTS: Abnormal elevated ALT was detected in 113 men (4.4%) and 188 women (6.6%). Most CVD risk factors associated positively with ALT in both sexes except systolic blood pressure and CRP (women only), while ALT was positively associated with age in men when adjusted for CVD risk factors, P < 0.001. BMI predicted ALT in men (OR 0.94; 95% CI 0.88–1.00, P = 0.047) and women (OR 0.90; 95% CI 0.86–0.95, P < 0.001). A linear inversed association between age and ALT in men and a non-linear inversed U-trend in women with maximum level between 60 and 64 years were found. CONCLUSION: This study confirms a positive relationship between ALT and CVD risk factors, particularly BMI. Age is not a major confounder in the ALT-CVD relationship, but separate sex-analyses is recommended in such studies. |
format |
Text |
author |
Bekkelund, Svein Ivar |
author_facet |
Bekkelund, Svein Ivar |
author_sort |
Bekkelund, Svein Ivar |
title |
Serum alanine aminotransferase activity and risk factors for cardiovascular disease in a Caucasian population: the Tromsø study |
title_short |
Serum alanine aminotransferase activity and risk factors for cardiovascular disease in a Caucasian population: the Tromsø study |
title_full |
Serum alanine aminotransferase activity and risk factors for cardiovascular disease in a Caucasian population: the Tromsø study |
title_fullStr |
Serum alanine aminotransferase activity and risk factors for cardiovascular disease in a Caucasian population: the Tromsø study |
title_full_unstemmed |
Serum alanine aminotransferase activity and risk factors for cardiovascular disease in a Caucasian population: the Tromsø study |
title_sort |
serum alanine aminotransferase activity and risk factors for cardiovascular disease in a caucasian population: the tromsø study |
publisher |
BioMed Central |
publishDate |
2021 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7805181/ https://doi.org/10.1186/s12872-020-01826-1 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_source |
BMC Cardiovasc Disord |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7805181/ http://dx.doi.org/10.1186/s12872-020-01826-1 |
op_rights |
© The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
op_rightsnorm |
CC0 PDM CC-BY |
op_doi |
https://doi.org/10.1186/s12872-020-01826-1 |
container_title |
BMC Cardiovascular Disorders |
container_volume |
21 |
container_issue |
1 |
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