Metabolic features of adiposity and glucose homoeostasis among school-aged inuit children from Nunavik (Northern Quebec, Canada)
In contrast to most Indigenous people in Canada, Inuit appeared until recently to have been protected from type 2 diabetes (T2D) related to obesity. We assessed the associations of metabolites (amino acids, acylcarnitines) with adiposity and biomarkers of T2D in school-aged Inuit children of Nunavik...
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ftpubmed:oai:pubmedcentral.nih.gov:7801047 2023-05-15T15:55:23+02:00 Metabolic features of adiposity and glucose homoeostasis among school-aged inuit children from Nunavik (Northern Quebec, Canada) Medehouenou, Thierry Comlan Marc Roy, Cynthia Tremblay, Pierre-Yves St-Jean, Audray Meziou, Salma Muckle, Gina Ayotte, Pierre Lucas, Michel 2021-01-04 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7801047/ http://www.ncbi.nlm.nih.gov/pubmed/33395372 https://doi.org/10.1080/22423982.2020.1858605 en eng Taylor & Francis http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7801047/ http://www.ncbi.nlm.nih.gov/pubmed/33395372 http://dx.doi.org/10.1080/22423982.2020.1858605 © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. http://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. CC-BY-NC Int J Circumpolar Health Original Research Article Text 2021 ftpubmed https://doi.org/10.1080/22423982.2020.1858605 2021-01-24T01:24:17Z In contrast to most Indigenous people in Canada, Inuit appeared until recently to have been protected from type 2 diabetes (T2D) related to obesity. We assessed the associations of metabolites (amino acids, acylcarnitines) with adiposity and biomarkers of T2D in school-aged Inuit children of Nunavik (Canada). Concentrations of metabolite were measured in plasma samples from a cross-sectional analysis of 248 children (mean age = 10.8 years). We assessed associations of plasma metabolites with adiposity measures (BMI, skinfold thicknesses) and T2D markers (insulin, glucose, adiponectin). Plasma concentrations of valine and tyrosine were higher in obese and overweight children compared to those of normal weight children (P < 0.05). An increment of 1-SD in BMI (SD = 3.3 kg/m(2)) was statistically associated with an increment of 0.21 (95% CI: 0.08, 0.33) for valine, 0.15 (95% CI: 0.02, 0.27) for isoleucine and 0.17 (95% CI: 0.04, 0.29) for tyrosine. Insulin concentration increased with concentrations of all amino acids (P < 0.05) except methionine. None of the acylcarnitines measured were statistically significantly associated with adiposity or T2D biomarkers A signature of metabolites, particularly higher levels of branched-chain amino acids, might allow for early detection of T2D among school-aged Inuit children. Text Circumpolar Health inuit Nunavik PubMed Central (PMC) Canada Nunavik International Journal of Circumpolar Health 80 1 1858605 |
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Original Research Article |
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Original Research Article Medehouenou, Thierry Comlan Marc Roy, Cynthia Tremblay, Pierre-Yves St-Jean, Audray Meziou, Salma Muckle, Gina Ayotte, Pierre Lucas, Michel Metabolic features of adiposity and glucose homoeostasis among school-aged inuit children from Nunavik (Northern Quebec, Canada) |
topic_facet |
Original Research Article |
description |
In contrast to most Indigenous people in Canada, Inuit appeared until recently to have been protected from type 2 diabetes (T2D) related to obesity. We assessed the associations of metabolites (amino acids, acylcarnitines) with adiposity and biomarkers of T2D in school-aged Inuit children of Nunavik (Canada). Concentrations of metabolite were measured in plasma samples from a cross-sectional analysis of 248 children (mean age = 10.8 years). We assessed associations of plasma metabolites with adiposity measures (BMI, skinfold thicknesses) and T2D markers (insulin, glucose, adiponectin). Plasma concentrations of valine and tyrosine were higher in obese and overweight children compared to those of normal weight children (P < 0.05). An increment of 1-SD in BMI (SD = 3.3 kg/m(2)) was statistically associated with an increment of 0.21 (95% CI: 0.08, 0.33) for valine, 0.15 (95% CI: 0.02, 0.27) for isoleucine and 0.17 (95% CI: 0.04, 0.29) for tyrosine. Insulin concentration increased with concentrations of all amino acids (P < 0.05) except methionine. None of the acylcarnitines measured were statistically significantly associated with adiposity or T2D biomarkers A signature of metabolites, particularly higher levels of branched-chain amino acids, might allow for early detection of T2D among school-aged Inuit children. |
format |
Text |
author |
Medehouenou, Thierry Comlan Marc Roy, Cynthia Tremblay, Pierre-Yves St-Jean, Audray Meziou, Salma Muckle, Gina Ayotte, Pierre Lucas, Michel |
author_facet |
Medehouenou, Thierry Comlan Marc Roy, Cynthia Tremblay, Pierre-Yves St-Jean, Audray Meziou, Salma Muckle, Gina Ayotte, Pierre Lucas, Michel |
author_sort |
Medehouenou, Thierry Comlan Marc |
title |
Metabolic features of adiposity and glucose homoeostasis among school-aged inuit children from Nunavik (Northern Quebec, Canada) |
title_short |
Metabolic features of adiposity and glucose homoeostasis among school-aged inuit children from Nunavik (Northern Quebec, Canada) |
title_full |
Metabolic features of adiposity and glucose homoeostasis among school-aged inuit children from Nunavik (Northern Quebec, Canada) |
title_fullStr |
Metabolic features of adiposity and glucose homoeostasis among school-aged inuit children from Nunavik (Northern Quebec, Canada) |
title_full_unstemmed |
Metabolic features of adiposity and glucose homoeostasis among school-aged inuit children from Nunavik (Northern Quebec, Canada) |
title_sort |
metabolic features of adiposity and glucose homoeostasis among school-aged inuit children from nunavik (northern quebec, canada) |
publisher |
Taylor & Francis |
publishDate |
2021 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7801047/ http://www.ncbi.nlm.nih.gov/pubmed/33395372 https://doi.org/10.1080/22423982.2020.1858605 |
geographic |
Canada Nunavik |
geographic_facet |
Canada Nunavik |
genre |
Circumpolar Health inuit Nunavik |
genre_facet |
Circumpolar Health inuit Nunavik |
op_source |
Int J Circumpolar Health |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7801047/ http://www.ncbi.nlm.nih.gov/pubmed/33395372 http://dx.doi.org/10.1080/22423982.2020.1858605 |
op_rights |
© 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. http://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
op_rightsnorm |
CC-BY-NC |
op_doi |
https://doi.org/10.1080/22423982.2020.1858605 |
container_title |
International Journal of Circumpolar Health |
container_volume |
80 |
container_issue |
1 |
container_start_page |
1858605 |
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1766390876466053120 |