The Effect of Orally Supplemented Melatonin on Larval Performance and Skeletal Deformities in Farmed Gilthead Seabream (Sparus aurata)
The gilthead seabream larval rearing in continuous light is common in most Mediterranean hatcheries to stimulate larval length growth and increase food consumption. Several studies have shown that continuous light affects larval development and increases the prevalence of skeletal deformities. Melat...
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ftpubmed:oai:pubmedcentral.nih.gov:7766509 2023-05-15T15:32:28+02:00 The Effect of Orally Supplemented Melatonin on Larval Performance and Skeletal Deformities in Farmed Gilthead Seabream (Sparus aurata) Mhalhel, Kamel Germanà, Antonino Abbate, Francesco Guerrera, Maria Cristina Levanti, Maria Laurà, Rosaria Montalbano, Giuseppe 2020-12-16 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766509/ http://www.ncbi.nlm.nih.gov/pubmed/33339403 https://doi.org/10.3390/ijms21249597 en eng MDPI http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766509/ http://www.ncbi.nlm.nih.gov/pubmed/33339403 http://dx.doi.org/10.3390/ijms21249597 © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). CC-BY Int J Mol Sci Article Text 2020 ftpubmed https://doi.org/10.3390/ijms21249597 2021-01-03T01:54:14Z The gilthead seabream larval rearing in continuous light is common in most Mediterranean hatcheries to stimulate larval length growth and increase food consumption. Several studies have shown that continuous light affects larval development and increases the prevalence of skeletal deformities. Melatonin is a crucial pineal neurohormone that displays daily secretion patterns, stimulates cell proliferation and embryonic development in Atlantic salmon and zebrafish, and improves osseointegration in mice and humans. However, no studies have examined the effects of orally supplemented melatonin on skeletal deformities in Sparus aurata larvae. We administered exogenous melatonin to gilthead seabream larvae via enriched rotifers and nauplii of Artemia. Exogenous melatonin induced bone deformities and stimulated parathyroid hormone-related protein-coding gene (PTHrP) mRNA expression. In addition to the melatonin-induced PTHrP high expression level, the recorded non coordinated function of skeletal muscle and bone during growth can be the fountainhead of bone deformities. Both myosin light chain 2 (mlc2) and bone gamma-carboxyglutamate protein-coding gene (bglap) expression levels were significantly affected by melatonin administration in an inverse dose–response manner during the exogenous melatonin administration. This is the first study to report the effect of inducing melatonin bone deformities on Sparus aurata larvae reared under ordinary hatchery conditions. Text Atlantic salmon PubMed Central (PMC) International Journal of Molecular Sciences 21 24 9597 |
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Article Mhalhel, Kamel Germanà, Antonino Abbate, Francesco Guerrera, Maria Cristina Levanti, Maria Laurà, Rosaria Montalbano, Giuseppe The Effect of Orally Supplemented Melatonin on Larval Performance and Skeletal Deformities in Farmed Gilthead Seabream (Sparus aurata) |
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Article |
description |
The gilthead seabream larval rearing in continuous light is common in most Mediterranean hatcheries to stimulate larval length growth and increase food consumption. Several studies have shown that continuous light affects larval development and increases the prevalence of skeletal deformities. Melatonin is a crucial pineal neurohormone that displays daily secretion patterns, stimulates cell proliferation and embryonic development in Atlantic salmon and zebrafish, and improves osseointegration in mice and humans. However, no studies have examined the effects of orally supplemented melatonin on skeletal deformities in Sparus aurata larvae. We administered exogenous melatonin to gilthead seabream larvae via enriched rotifers and nauplii of Artemia. Exogenous melatonin induced bone deformities and stimulated parathyroid hormone-related protein-coding gene (PTHrP) mRNA expression. In addition to the melatonin-induced PTHrP high expression level, the recorded non coordinated function of skeletal muscle and bone during growth can be the fountainhead of bone deformities. Both myosin light chain 2 (mlc2) and bone gamma-carboxyglutamate protein-coding gene (bglap) expression levels were significantly affected by melatonin administration in an inverse dose–response manner during the exogenous melatonin administration. This is the first study to report the effect of inducing melatonin bone deformities on Sparus aurata larvae reared under ordinary hatchery conditions. |
format |
Text |
author |
Mhalhel, Kamel Germanà, Antonino Abbate, Francesco Guerrera, Maria Cristina Levanti, Maria Laurà, Rosaria Montalbano, Giuseppe |
author_facet |
Mhalhel, Kamel Germanà, Antonino Abbate, Francesco Guerrera, Maria Cristina Levanti, Maria Laurà, Rosaria Montalbano, Giuseppe |
author_sort |
Mhalhel, Kamel |
title |
The Effect of Orally Supplemented Melatonin on Larval Performance and Skeletal Deformities in Farmed Gilthead Seabream (Sparus aurata) |
title_short |
The Effect of Orally Supplemented Melatonin on Larval Performance and Skeletal Deformities in Farmed Gilthead Seabream (Sparus aurata) |
title_full |
The Effect of Orally Supplemented Melatonin on Larval Performance and Skeletal Deformities in Farmed Gilthead Seabream (Sparus aurata) |
title_fullStr |
The Effect of Orally Supplemented Melatonin on Larval Performance and Skeletal Deformities in Farmed Gilthead Seabream (Sparus aurata) |
title_full_unstemmed |
The Effect of Orally Supplemented Melatonin on Larval Performance and Skeletal Deformities in Farmed Gilthead Seabream (Sparus aurata) |
title_sort |
effect of orally supplemented melatonin on larval performance and skeletal deformities in farmed gilthead seabream (sparus aurata) |
publisher |
MDPI |
publishDate |
2020 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766509/ http://www.ncbi.nlm.nih.gov/pubmed/33339403 https://doi.org/10.3390/ijms21249597 |
genre |
Atlantic salmon |
genre_facet |
Atlantic salmon |
op_source |
Int J Mol Sci |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766509/ http://www.ncbi.nlm.nih.gov/pubmed/33339403 http://dx.doi.org/10.3390/ijms21249597 |
op_rights |
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.3390/ijms21249597 |
container_title |
International Journal of Molecular Sciences |
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21 |
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24 |
container_start_page |
9597 |
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1766362960457891840 |