Antarctic Krill Oil Ameliorates Monosodium Iodoacetate-Induced Irregularities in Articular Cartilage and Inflammatory Response in the Rat Models of Osteoarthritis
The aim of this study was to examine the effects of Antarctic krill oil (FJH-KO) in a rat model of monosodium iodoacetate (MIA) induced osteoarthritis. The effect of FJH-KO on the development and severity of MIA-induced osteoarthritis was assessed using hematoxylin and eosin (H&E) staining and m...
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ftpubmed:oai:pubmedcentral.nih.gov:7699584 2023-05-15T13:46:03+02:00 Antarctic Krill Oil Ameliorates Monosodium Iodoacetate-Induced Irregularities in Articular Cartilage and Inflammatory Response in the Rat Models of Osteoarthritis Lee, Minhee Kim, Dakyung Park, Soo-Jeung Yun, Jeong moon Oh, Dong Hwan Lee, Jeongmin 2020-11-20 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699584/ http://www.ncbi.nlm.nih.gov/pubmed/33233504 https://doi.org/10.3390/nu12113550 en eng MDPI http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699584/ http://www.ncbi.nlm.nih.gov/pubmed/33233504 http://dx.doi.org/10.3390/nu12113550 © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). CC-BY Nutrients Article Text 2020 ftpubmed https://doi.org/10.3390/nu12113550 2020-12-06T02:01:23Z The aim of this study was to examine the effects of Antarctic krill oil (FJH-KO) in a rat model of monosodium iodoacetate (MIA) induced osteoarthritis. The effect of FJH-KO on the development and severity of MIA-induced osteoarthritis was assessed using hematoxylin and eosin (H&E) staining and micro-CT. The expression of PGE(2), pro-inflammatory cytokines (IL-1β, TNF-α), and arthritics related genes in osteoarthritic rats in response to FJH-KO supplementation was investigated using real time PCR. FJH-KO supplementation in the arthritic rat model reduced tissue damage, cartilage degeneration, and reduced the MIA-induced irregularities in articular cartilage surface. Serum PGE(2), IL-1β, IL-6, and TNF-α levels were higher in MIA treated animals, but these levels decreased upon FJH-KO supplementation. When FJH-KO was provided at a dose of 150 mg/kg b.w to MIA-treated animals, it significantly increased the mRNA expression of anabolic factors. The mRNA expression of catabolic factors was significantly decreased MIA-treated animals that were provided FJH-KO at a dose of 100 and 150 mg/kg b.w. Moreover, the mRNA expression of inflammatory mediators was significantly decreased MIA-treated animals supplemented with FJH-KO. These results suggest supplementation with FJH-KO ameliorates the irregularities in articular cartilage surface and improves the inflammatory response in the osteoarthritis. Thus, FJH-KO could serve as a potential therapeutic agent for osteoarthritis treatment. Text Antarc* Antarctic Antarctic Krill PubMed Central (PMC) Antarctic Nutrients 12 11 3550 |
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Article Lee, Minhee Kim, Dakyung Park, Soo-Jeung Yun, Jeong moon Oh, Dong Hwan Lee, Jeongmin Antarctic Krill Oil Ameliorates Monosodium Iodoacetate-Induced Irregularities in Articular Cartilage and Inflammatory Response in the Rat Models of Osteoarthritis |
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The aim of this study was to examine the effects of Antarctic krill oil (FJH-KO) in a rat model of monosodium iodoacetate (MIA) induced osteoarthritis. The effect of FJH-KO on the development and severity of MIA-induced osteoarthritis was assessed using hematoxylin and eosin (H&E) staining and micro-CT. The expression of PGE(2), pro-inflammatory cytokines (IL-1β, TNF-α), and arthritics related genes in osteoarthritic rats in response to FJH-KO supplementation was investigated using real time PCR. FJH-KO supplementation in the arthritic rat model reduced tissue damage, cartilage degeneration, and reduced the MIA-induced irregularities in articular cartilage surface. Serum PGE(2), IL-1β, IL-6, and TNF-α levels were higher in MIA treated animals, but these levels decreased upon FJH-KO supplementation. When FJH-KO was provided at a dose of 150 mg/kg b.w to MIA-treated animals, it significantly increased the mRNA expression of anabolic factors. The mRNA expression of catabolic factors was significantly decreased MIA-treated animals that were provided FJH-KO at a dose of 100 and 150 mg/kg b.w. Moreover, the mRNA expression of inflammatory mediators was significantly decreased MIA-treated animals supplemented with FJH-KO. These results suggest supplementation with FJH-KO ameliorates the irregularities in articular cartilage surface and improves the inflammatory response in the osteoarthritis. Thus, FJH-KO could serve as a potential therapeutic agent for osteoarthritis treatment. |
format |
Text |
author |
Lee, Minhee Kim, Dakyung Park, Soo-Jeung Yun, Jeong moon Oh, Dong Hwan Lee, Jeongmin |
author_facet |
Lee, Minhee Kim, Dakyung Park, Soo-Jeung Yun, Jeong moon Oh, Dong Hwan Lee, Jeongmin |
author_sort |
Lee, Minhee |
title |
Antarctic Krill Oil Ameliorates Monosodium Iodoacetate-Induced Irregularities in Articular Cartilage and Inflammatory Response in the Rat Models of Osteoarthritis |
title_short |
Antarctic Krill Oil Ameliorates Monosodium Iodoacetate-Induced Irregularities in Articular Cartilage and Inflammatory Response in the Rat Models of Osteoarthritis |
title_full |
Antarctic Krill Oil Ameliorates Monosodium Iodoacetate-Induced Irregularities in Articular Cartilage and Inflammatory Response in the Rat Models of Osteoarthritis |
title_fullStr |
Antarctic Krill Oil Ameliorates Monosodium Iodoacetate-Induced Irregularities in Articular Cartilage and Inflammatory Response in the Rat Models of Osteoarthritis |
title_full_unstemmed |
Antarctic Krill Oil Ameliorates Monosodium Iodoacetate-Induced Irregularities in Articular Cartilage and Inflammatory Response in the Rat Models of Osteoarthritis |
title_sort |
antarctic krill oil ameliorates monosodium iodoacetate-induced irregularities in articular cartilage and inflammatory response in the rat models of osteoarthritis |
publisher |
MDPI |
publishDate |
2020 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699584/ http://www.ncbi.nlm.nih.gov/pubmed/33233504 https://doi.org/10.3390/nu12113550 |
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Antarctic |
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Antarctic |
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Antarc* Antarctic Antarctic Krill |
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Antarc* Antarctic Antarctic Krill |
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Nutrients |
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699584/ http://www.ncbi.nlm.nih.gov/pubmed/33233504 http://dx.doi.org/10.3390/nu12113550 |
op_rights |
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
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CC-BY |
op_doi |
https://doi.org/10.3390/nu12113550 |
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Nutrients |
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3550 |
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