Remission of adult-onset asthma is rare: a 15-year follow-up study
BACKGROUND: There are few long-term clinical follow-up studies of adult-onset asthma. The aim of this article was to study clinical characteristics of adult-onset asthma in relation to remission and persistence of the disease in a 15-year follow-up. METHODS: A cohort of 309 adults aged 20–60 years w...
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ftpubmed:oai:pubmedcentral.nih.gov:7680910 2023-05-15T17:44:58+02:00 Remission of adult-onset asthma is rare: a 15-year follow-up study Almqvist, Linnéa Rönmark, Eva Stridsman, Caroline Backman, Helena Lindberg, Anne Lundbäck, Bo Hedman, Linnéa 2020-11-23 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7680910/ http://www.ncbi.nlm.nih.gov/pubmed/33263024 https://doi.org/10.1183/23120541.00620-2020 en eng European Respiratory Society http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7680910/ http://www.ncbi.nlm.nih.gov/pubmed/33263024 http://dx.doi.org/10.1183/23120541.00620-2020 Copyright ©ERS 2020 http://creativecommons.org/licenses/by-nc/4.0/This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. CC-BY-NC ERJ Open Res Original Articles Text 2020 ftpubmed https://doi.org/10.1183/23120541.00620-2020 2020-12-06T01:37:38Z BACKGROUND: There are few long-term clinical follow-up studies of adult-onset asthma. The aim of this article was to study clinical characteristics of adult-onset asthma in relation to remission and persistence of the disease in a 15-year follow-up. METHODS: A cohort of 309 adults aged 20–60 years with asthma onset during the last 12 months verified by bronchial variability, was recruited between 1995 and 1999 from the general population in northern Sweden. The cohort was followed-up in 2003 (n=250) and between 2012 and 2014 (n=205). Structured interviews and spirometry were performed at recruitment and the follow-ups. Bronchial hyperreactivity (BHR) and skin-prick tests were performed at recruitment and blood samples were collected at the last follow-up. Remission of asthma was defined as no asthma symptoms and no use of asthma medication during the last 12 months. RESULTS: Of eight individuals in remission in 2003, five had relapsed between 2012 and 2014 and in total, 23 (11%) were in remission, while 182 had persistent asthma. Those in remission had higher mean forced expiratory volume in 1 s % predicted at recruitment than those with persistent asthma (94.6 versus 88.3, p=0.034), fewer had severe BHR (27.3% versus 50.9%, p=0.037) and they had less body mass index increase (+1.6 versus +3.0, p=0.054). Of those with persistent asthma, 13% had uncontrolled asthma and they had higher levels of blood neutrophils than those with partly controlled or controlled asthma. CONCLUSION: Higher forced expiratory volume in 1 s % predicted and less-severe BHR was associated with remission of adult-onset asthma, but still, the proportion in remission in this 15-year follow-up was low. Text Northern Sweden PubMed Central (PMC) ERJ Open Research 6 4 00620-2020 |
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Original Articles |
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Original Articles Almqvist, Linnéa Rönmark, Eva Stridsman, Caroline Backman, Helena Lindberg, Anne Lundbäck, Bo Hedman, Linnéa Remission of adult-onset asthma is rare: a 15-year follow-up study |
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Original Articles |
description |
BACKGROUND: There are few long-term clinical follow-up studies of adult-onset asthma. The aim of this article was to study clinical characteristics of adult-onset asthma in relation to remission and persistence of the disease in a 15-year follow-up. METHODS: A cohort of 309 adults aged 20–60 years with asthma onset during the last 12 months verified by bronchial variability, was recruited between 1995 and 1999 from the general population in northern Sweden. The cohort was followed-up in 2003 (n=250) and between 2012 and 2014 (n=205). Structured interviews and spirometry were performed at recruitment and the follow-ups. Bronchial hyperreactivity (BHR) and skin-prick tests were performed at recruitment and blood samples were collected at the last follow-up. Remission of asthma was defined as no asthma symptoms and no use of asthma medication during the last 12 months. RESULTS: Of eight individuals in remission in 2003, five had relapsed between 2012 and 2014 and in total, 23 (11%) were in remission, while 182 had persistent asthma. Those in remission had higher mean forced expiratory volume in 1 s % predicted at recruitment than those with persistent asthma (94.6 versus 88.3, p=0.034), fewer had severe BHR (27.3% versus 50.9%, p=0.037) and they had less body mass index increase (+1.6 versus +3.0, p=0.054). Of those with persistent asthma, 13% had uncontrolled asthma and they had higher levels of blood neutrophils than those with partly controlled or controlled asthma. CONCLUSION: Higher forced expiratory volume in 1 s % predicted and less-severe BHR was associated with remission of adult-onset asthma, but still, the proportion in remission in this 15-year follow-up was low. |
format |
Text |
author |
Almqvist, Linnéa Rönmark, Eva Stridsman, Caroline Backman, Helena Lindberg, Anne Lundbäck, Bo Hedman, Linnéa |
author_facet |
Almqvist, Linnéa Rönmark, Eva Stridsman, Caroline Backman, Helena Lindberg, Anne Lundbäck, Bo Hedman, Linnéa |
author_sort |
Almqvist, Linnéa |
title |
Remission of adult-onset asthma is rare: a 15-year follow-up study |
title_short |
Remission of adult-onset asthma is rare: a 15-year follow-up study |
title_full |
Remission of adult-onset asthma is rare: a 15-year follow-up study |
title_fullStr |
Remission of adult-onset asthma is rare: a 15-year follow-up study |
title_full_unstemmed |
Remission of adult-onset asthma is rare: a 15-year follow-up study |
title_sort |
remission of adult-onset asthma is rare: a 15-year follow-up study |
publisher |
European Respiratory Society |
publishDate |
2020 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7680910/ http://www.ncbi.nlm.nih.gov/pubmed/33263024 https://doi.org/10.1183/23120541.00620-2020 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_source |
ERJ Open Res |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7680910/ http://www.ncbi.nlm.nih.gov/pubmed/33263024 http://dx.doi.org/10.1183/23120541.00620-2020 |
op_rights |
Copyright ©ERS 2020 http://creativecommons.org/licenses/by-nc/4.0/This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. |
op_rightsnorm |
CC-BY-NC |
op_doi |
https://doi.org/10.1183/23120541.00620-2020 |
container_title |
ERJ Open Research |
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6 |
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4 |
container_start_page |
00620-2020 |
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1766147661534068736 |