Increased calcium intake is associated lower serum 25-hydroxyvitamin D levels in subjects with adequate vitamin D intake: a population-based observational study
BACKGROUND: There are indications that an increased intake of calcium has a vitamin D sparing effect, which might be explained by a decreased catabolism of 25-hydroxyvitamin D (25(OH)D). However, there are only a few studies where this has been examined. METHOD: In the seventh survey of the Tromsø s...
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ftpubmed:oai:pubmedcentral.nih.gov:7604942 2023-05-15T18:34:42+02:00 Increased calcium intake is associated lower serum 25-hydroxyvitamin D levels in subjects with adequate vitamin D intake: a population-based observational study Jorde, Rolf Grimnes, Guri 2020-11-02 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7604942/ https://doi.org/10.1186/s40795-020-00381-4 en eng BioMed Central http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7604942/ http://dx.doi.org/10.1186/s40795-020-00381-4 © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. CC0 PDM CC-BY BMC Nutr Research Article Text 2020 ftpubmed https://doi.org/10.1186/s40795-020-00381-4 2020-11-08T02:01:12Z BACKGROUND: There are indications that an increased intake of calcium has a vitamin D sparing effect, which might be explained by a decreased catabolism of 25-hydroxyvitamin D (25(OH)D). However, there are only a few studies where this has been examined. METHOD: In the seventh survey of the Tromsø study, serum 25(OH)D and parathyroid hormone were measured, and questionnaires on calcium and vitamin D intakes filled in. RESULTS: There were significant interactions between sex, calcium and vitamin D intakes regarding serum 25(OH)D level. The analyses were therefore done stratified. In males there was, regardless of vitamin D intake, a significant decrease in serum 25(OH)D with increasing calcium intake. The difference in serum 25(OH)D between those with the highest and lowest calcium intakes was approximately 10%. In the females, there was in subjects with low vitamin D intake (< 7 μg/d) a significant increase in serum 25(OH)D with increasing calcium intake, which could not be explained by secondary hyperparathyroidism. In females with higher vitamin D intakes, increasing calcium intake was associated with lower serum 25(OH)D levels. CONCLUSIONS: There is, at least in subjects with an adequate vitamin D intake, a negative association between calcium intake and serum 25(OH)D. Text Tromsø PubMed Central (PMC) Tromsø BMC Nutrition 6 1 |
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Research Article Jorde, Rolf Grimnes, Guri Increased calcium intake is associated lower serum 25-hydroxyvitamin D levels in subjects with adequate vitamin D intake: a population-based observational study |
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Research Article |
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BACKGROUND: There are indications that an increased intake of calcium has a vitamin D sparing effect, which might be explained by a decreased catabolism of 25-hydroxyvitamin D (25(OH)D). However, there are only a few studies where this has been examined. METHOD: In the seventh survey of the Tromsø study, serum 25(OH)D and parathyroid hormone were measured, and questionnaires on calcium and vitamin D intakes filled in. RESULTS: There were significant interactions between sex, calcium and vitamin D intakes regarding serum 25(OH)D level. The analyses were therefore done stratified. In males there was, regardless of vitamin D intake, a significant decrease in serum 25(OH)D with increasing calcium intake. The difference in serum 25(OH)D between those with the highest and lowest calcium intakes was approximately 10%. In the females, there was in subjects with low vitamin D intake (< 7 μg/d) a significant increase in serum 25(OH)D with increasing calcium intake, which could not be explained by secondary hyperparathyroidism. In females with higher vitamin D intakes, increasing calcium intake was associated with lower serum 25(OH)D levels. CONCLUSIONS: There is, at least in subjects with an adequate vitamin D intake, a negative association between calcium intake and serum 25(OH)D. |
format |
Text |
author |
Jorde, Rolf Grimnes, Guri |
author_facet |
Jorde, Rolf Grimnes, Guri |
author_sort |
Jorde, Rolf |
title |
Increased calcium intake is associated lower serum 25-hydroxyvitamin D levels in subjects with adequate vitamin D intake: a population-based observational study |
title_short |
Increased calcium intake is associated lower serum 25-hydroxyvitamin D levels in subjects with adequate vitamin D intake: a population-based observational study |
title_full |
Increased calcium intake is associated lower serum 25-hydroxyvitamin D levels in subjects with adequate vitamin D intake: a population-based observational study |
title_fullStr |
Increased calcium intake is associated lower serum 25-hydroxyvitamin D levels in subjects with adequate vitamin D intake: a population-based observational study |
title_full_unstemmed |
Increased calcium intake is associated lower serum 25-hydroxyvitamin D levels in subjects with adequate vitamin D intake: a population-based observational study |
title_sort |
increased calcium intake is associated lower serum 25-hydroxyvitamin d levels in subjects with adequate vitamin d intake: a population-based observational study |
publisher |
BioMed Central |
publishDate |
2020 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7604942/ https://doi.org/10.1186/s40795-020-00381-4 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_source |
BMC Nutr |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7604942/ http://dx.doi.org/10.1186/s40795-020-00381-4 |
op_rights |
© The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
op_rightsnorm |
CC0 PDM CC-BY |
op_doi |
https://doi.org/10.1186/s40795-020-00381-4 |
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BMC Nutrition |
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6 |
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