Dipeptide YA is Responsible for the Positive Effect of Oyster Hydrolysates on Alcohol Metabolism in Single Ethanol Binge Rodent Models
Accumulative alcohol hangovers cause liver damage through oxidative and inflammatory stress. Numerous antioxidant and anti-inflammatory reagents have been developed to reduce alcohol hangovers, but these reagents are still insignificant and have limitations in that they can cause liver toxicity. Oys...
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ftpubmed:oai:pubmedcentral.nih.gov:7601867 2023-05-15T15:58:51+02:00 Dipeptide YA is Responsible for the Positive Effect of Oyster Hydrolysates on Alcohol Metabolism in Single Ethanol Binge Rodent Models Siregar, Adrian S. Nyiramana, Marie Merci Kim, Eun-Jin Shin, Eui-Jung Woo, Min Seok Kim, Jin-Mok Kim, Jung Hwan Lee, Dong Kun Hahm, Jong Ryeal Kim, Hyun Joon Kim, Chang-Woon Kim, Nam-Gil Park, Si-Hyang Choi, Yeung Joon Kang, Sang Soo Hong, Seong-Geun Han, Jaehee Kang, Dawon 2020-10-11 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601867/ http://www.ncbi.nlm.nih.gov/pubmed/33050644 https://doi.org/10.3390/md18100512 en eng MDPI http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601867/ http://www.ncbi.nlm.nih.gov/pubmed/33050644 http://dx.doi.org/10.3390/md18100512 © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). CC-BY Mar Drugs Article Text 2020 ftpubmed https://doi.org/10.3390/md18100512 2020-11-08T01:54:25Z Accumulative alcohol hangovers cause liver damage through oxidative and inflammatory stress. Numerous antioxidant and anti-inflammatory reagents have been developed to reduce alcohol hangovers, but these reagents are still insignificant and have limitations in that they can cause liver toxicity. Oyster hydrolysate (OH), another reagent that has antioxidant and anti-inflammatory activity, is a product extracted through an enzymatic hydrolysis process from oysters (Crassostrea gigas), which can be easily eaten in meals. This study was aimed at determining the effects of OH on alcohol metabolism, using a single high dose of ethanol (EtOH) administered to rodents, by monitoring alcohol metabolic enzymes, oxidative stress signals, and inflammatory mediators. The effect of tyrosine-alanine (YA) peptide, a main component of OH, on EtOH metabolism was also identified. In vitro experiments showed that OH pretreatment inhibited EtOH-induced cell death, oxidative stress, and inflammation in liver cells and macrophages. In vivo experiments showed that OH and YA pre-administration increased alcohol dehydrogenase, aldehyde dehydrogenase, and catalase activity in EtOH binge treatment. In addition, OH pre-administration alleviated CYP2E1 activity, ROS production, apoptotic signals, and inflammatory mediators in liver tissues. These results showed that OH and YA enhanced EtOH metabolism and had a protective effect against acute alcohol liver damage. Our findings offer new insights into a single high dose of EtOH drinking and suggest that OH and YA could be used as potential marine functional foods to prevent acute alcohol-induced liver damage. Text Crassostrea gigas PubMed Central (PMC) Marine Drugs 18 10 512 |
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Article |
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Article Siregar, Adrian S. Nyiramana, Marie Merci Kim, Eun-Jin Shin, Eui-Jung Woo, Min Seok Kim, Jin-Mok Kim, Jung Hwan Lee, Dong Kun Hahm, Jong Ryeal Kim, Hyun Joon Kim, Chang-Woon Kim, Nam-Gil Park, Si-Hyang Choi, Yeung Joon Kang, Sang Soo Hong, Seong-Geun Han, Jaehee Kang, Dawon Dipeptide YA is Responsible for the Positive Effect of Oyster Hydrolysates on Alcohol Metabolism in Single Ethanol Binge Rodent Models |
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Article |
description |
Accumulative alcohol hangovers cause liver damage through oxidative and inflammatory stress. Numerous antioxidant and anti-inflammatory reagents have been developed to reduce alcohol hangovers, but these reagents are still insignificant and have limitations in that they can cause liver toxicity. Oyster hydrolysate (OH), another reagent that has antioxidant and anti-inflammatory activity, is a product extracted through an enzymatic hydrolysis process from oysters (Crassostrea gigas), which can be easily eaten in meals. This study was aimed at determining the effects of OH on alcohol metabolism, using a single high dose of ethanol (EtOH) administered to rodents, by monitoring alcohol metabolic enzymes, oxidative stress signals, and inflammatory mediators. The effect of tyrosine-alanine (YA) peptide, a main component of OH, on EtOH metabolism was also identified. In vitro experiments showed that OH pretreatment inhibited EtOH-induced cell death, oxidative stress, and inflammation in liver cells and macrophages. In vivo experiments showed that OH and YA pre-administration increased alcohol dehydrogenase, aldehyde dehydrogenase, and catalase activity in EtOH binge treatment. In addition, OH pre-administration alleviated CYP2E1 activity, ROS production, apoptotic signals, and inflammatory mediators in liver tissues. These results showed that OH and YA enhanced EtOH metabolism and had a protective effect against acute alcohol liver damage. Our findings offer new insights into a single high dose of EtOH drinking and suggest that OH and YA could be used as potential marine functional foods to prevent acute alcohol-induced liver damage. |
format |
Text |
author |
Siregar, Adrian S. Nyiramana, Marie Merci Kim, Eun-Jin Shin, Eui-Jung Woo, Min Seok Kim, Jin-Mok Kim, Jung Hwan Lee, Dong Kun Hahm, Jong Ryeal Kim, Hyun Joon Kim, Chang-Woon Kim, Nam-Gil Park, Si-Hyang Choi, Yeung Joon Kang, Sang Soo Hong, Seong-Geun Han, Jaehee Kang, Dawon |
author_facet |
Siregar, Adrian S. Nyiramana, Marie Merci Kim, Eun-Jin Shin, Eui-Jung Woo, Min Seok Kim, Jin-Mok Kim, Jung Hwan Lee, Dong Kun Hahm, Jong Ryeal Kim, Hyun Joon Kim, Chang-Woon Kim, Nam-Gil Park, Si-Hyang Choi, Yeung Joon Kang, Sang Soo Hong, Seong-Geun Han, Jaehee Kang, Dawon |
author_sort |
Siregar, Adrian S. |
title |
Dipeptide YA is Responsible for the Positive Effect of Oyster Hydrolysates on Alcohol Metabolism in Single Ethanol Binge Rodent Models |
title_short |
Dipeptide YA is Responsible for the Positive Effect of Oyster Hydrolysates on Alcohol Metabolism in Single Ethanol Binge Rodent Models |
title_full |
Dipeptide YA is Responsible for the Positive Effect of Oyster Hydrolysates on Alcohol Metabolism in Single Ethanol Binge Rodent Models |
title_fullStr |
Dipeptide YA is Responsible for the Positive Effect of Oyster Hydrolysates on Alcohol Metabolism in Single Ethanol Binge Rodent Models |
title_full_unstemmed |
Dipeptide YA is Responsible for the Positive Effect of Oyster Hydrolysates on Alcohol Metabolism in Single Ethanol Binge Rodent Models |
title_sort |
dipeptide ya is responsible for the positive effect of oyster hydrolysates on alcohol metabolism in single ethanol binge rodent models |
publisher |
MDPI |
publishDate |
2020 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601867/ http://www.ncbi.nlm.nih.gov/pubmed/33050644 https://doi.org/10.3390/md18100512 |
genre |
Crassostrea gigas |
genre_facet |
Crassostrea gigas |
op_source |
Mar Drugs |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601867/ http://www.ncbi.nlm.nih.gov/pubmed/33050644 http://dx.doi.org/10.3390/md18100512 |
op_rights |
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.3390/md18100512 |
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Marine Drugs |
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18 |
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10 |
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512 |
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1766394612579041280 |