The hemoglobin Gly16β1Asp polymorphism in turbot (Scophthalmus maximus) is differentially distributed across European populations
Turbot is an important flatfish widely distributed along the European coasts, whose fishery is centered in the North Sea. The commercial value of the species has boosted a successful aquaculture sector in Europe and China. Body growth is the main target of turbot breeding programs and is also a key...
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ftpubmed:oai:pubmedcentral.nih.gov:7584550 2023-05-15T18:15:52+02:00 The hemoglobin Gly16β1Asp polymorphism in turbot (Scophthalmus maximus) is differentially distributed across European populations Andersen, Øivind Rubiolo, Juan Andrés De Rosa, Maria Cristina Martinez, Paulino 2020-10-04 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7584550/ http://www.ncbi.nlm.nih.gov/pubmed/33011865 https://doi.org/10.1007/s10695-020-00872-y en eng Springer Netherlands http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7584550/ http://www.ncbi.nlm.nih.gov/pubmed/33011865 http://dx.doi.org/10.1007/s10695-020-00872-y © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. CC-BY Fish Physiol Biochem Article Text 2020 ftpubmed https://doi.org/10.1007/s10695-020-00872-y 2020-11-01T01:52:28Z Turbot is an important flatfish widely distributed along the European coasts, whose fishery is centered in the North Sea. The commercial value of the species has boosted a successful aquaculture sector in Europe and China. Body growth is the main target of turbot breeding programs and is also a key trait related to local adaptation to temperature and salinity. Differences in growth rate and optimal growth temperature in turbot have been shown to be associated with a hemoglobin polymorphism reported more than 50 years ago. Here, we identified a Gly16Asp amino acid substitution in the β1 globin subunit by searching for genetic variation in the five functional globin genes within the whole annotated turbot genome. We predicted increased stability of the turbot hemoglobin by the replacement of the conserved Gly with the negative charged Asp residue that is consistent with the higher rate of αβ dimer assembly in the human J-Baltimore Gly16β->Asp mutant than in normal HbA. The turbot Hbβ1-Gly16 variant dominated in the northern populations examined, particularly in the Baltic Sea, while the Asp allele showed elevated frequencies in southern populations and was the prevalent variant in the Adriatic Sea. Body weight did not associate with the Hbβ1 genotypes at farming conditions (i.e., high oxygen levels, feeding ad libitum) after analyzing 90 fish with high growth dispersal from nine turbot families. Nevertheless, all data at hand suggest that the turbot hemoglobin polymorphism has an adaptive significance in the variable wild conditions regarding temperature and oxygen availability. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s10695-020-00872-y) contains supplementary material, which is available to authorized users. Text Scophthalmus maximus Turbot PubMed Central (PMC) Fish Physiology and Biochemistry 46 6 2367 2376 |
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Article Andersen, Øivind Rubiolo, Juan Andrés De Rosa, Maria Cristina Martinez, Paulino The hemoglobin Gly16β1Asp polymorphism in turbot (Scophthalmus maximus) is differentially distributed across European populations |
topic_facet |
Article |
description |
Turbot is an important flatfish widely distributed along the European coasts, whose fishery is centered in the North Sea. The commercial value of the species has boosted a successful aquaculture sector in Europe and China. Body growth is the main target of turbot breeding programs and is also a key trait related to local adaptation to temperature and salinity. Differences in growth rate and optimal growth temperature in turbot have been shown to be associated with a hemoglobin polymorphism reported more than 50 years ago. Here, we identified a Gly16Asp amino acid substitution in the β1 globin subunit by searching for genetic variation in the five functional globin genes within the whole annotated turbot genome. We predicted increased stability of the turbot hemoglobin by the replacement of the conserved Gly with the negative charged Asp residue that is consistent with the higher rate of αβ dimer assembly in the human J-Baltimore Gly16β->Asp mutant than in normal HbA. The turbot Hbβ1-Gly16 variant dominated in the northern populations examined, particularly in the Baltic Sea, while the Asp allele showed elevated frequencies in southern populations and was the prevalent variant in the Adriatic Sea. Body weight did not associate with the Hbβ1 genotypes at farming conditions (i.e., high oxygen levels, feeding ad libitum) after analyzing 90 fish with high growth dispersal from nine turbot families. Nevertheless, all data at hand suggest that the turbot hemoglobin polymorphism has an adaptive significance in the variable wild conditions regarding temperature and oxygen availability. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s10695-020-00872-y) contains supplementary material, which is available to authorized users. |
format |
Text |
author |
Andersen, Øivind Rubiolo, Juan Andrés De Rosa, Maria Cristina Martinez, Paulino |
author_facet |
Andersen, Øivind Rubiolo, Juan Andrés De Rosa, Maria Cristina Martinez, Paulino |
author_sort |
Andersen, Øivind |
title |
The hemoglobin Gly16β1Asp polymorphism in turbot (Scophthalmus maximus) is differentially distributed across European populations |
title_short |
The hemoglobin Gly16β1Asp polymorphism in turbot (Scophthalmus maximus) is differentially distributed across European populations |
title_full |
The hemoglobin Gly16β1Asp polymorphism in turbot (Scophthalmus maximus) is differentially distributed across European populations |
title_fullStr |
The hemoglobin Gly16β1Asp polymorphism in turbot (Scophthalmus maximus) is differentially distributed across European populations |
title_full_unstemmed |
The hemoglobin Gly16β1Asp polymorphism in turbot (Scophthalmus maximus) is differentially distributed across European populations |
title_sort |
hemoglobin gly16β1asp polymorphism in turbot (scophthalmus maximus) is differentially distributed across european populations |
publisher |
Springer Netherlands |
publishDate |
2020 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7584550/ http://www.ncbi.nlm.nih.gov/pubmed/33011865 https://doi.org/10.1007/s10695-020-00872-y |
genre |
Scophthalmus maximus Turbot |
genre_facet |
Scophthalmus maximus Turbot |
op_source |
Fish Physiol Biochem |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7584550/ http://www.ncbi.nlm.nih.gov/pubmed/33011865 http://dx.doi.org/10.1007/s10695-020-00872-y |
op_rights |
© The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1007/s10695-020-00872-y |
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Fish Physiology and Biochemistry |
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46 |
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6 |
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2367 |
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2376 |
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1766189110579429376 |