The immune response of bats differs between pre-migration and migration seasons
Maintaining a competent immune system is energetically costly and thus immunity may be traded against other costly traits such as seasonal migration. Here, we tested in long-distance migratory Nathusius’ pipistrelles (Pipistrellus nathusii), if selected branches of immunity are expressed differently...
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ftpubmed:oai:pubmedcentral.nih.gov:7562910 2023-05-15T17:59:45+02:00 The immune response of bats differs between pre-migration and migration seasons Voigt, Christian C. Fritze, Marcus Lindecke, Oliver Costantini, David Pētersons, Gunārs Czirják, Gábor Á. 2020-10-15 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7562910/ http://www.ncbi.nlm.nih.gov/pubmed/33060711 https://doi.org/10.1038/s41598-020-74473-3 en eng Nature Publishing Group UK http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7562910/ http://www.ncbi.nlm.nih.gov/pubmed/33060711 http://dx.doi.org/10.1038/s41598-020-74473-3 © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. CC-BY Sci Rep Article Text 2020 ftpubmed https://doi.org/10.1038/s41598-020-74473-3 2020-10-25T00:41:55Z Maintaining a competent immune system is energetically costly and thus immunity may be traded against other costly traits such as seasonal migration. Here, we tested in long-distance migratory Nathusius’ pipistrelles (Pipistrellus nathusii), if selected branches of immunity are expressed differently in response to the energy demands and oxidative stress of aerial migration. During the migration period, we observed higher baseline lymphocyte and lower neutrophil levels than during the pre-migration period, but no stronger response of cellular effectors to an antigen challenge. Baseline plasma haptoglobin, as a component of the humoral innate immunity, remained similar during both seasons, yet baseline plasma haptoglobin levels increased by a factor of 7.8 in migratory bats during an immune challenge, whereas they did not change during the pre-migration period. Oxidative stress was higher during migration than during pre-migration, yet there was no association between blood oxidative status and immune parameters, and immune challenge did not trigger any changes in oxidative stress, irrespective of season. Our findings suggest that humoral effectors of the acute phase response may play a stronger role in the first-line defense against infections for migrating bats compared to non-migrating bats. We conclude that Nathusius’ pipistrelles allocate resources differently into the branches of their immune system, most likely following current demands resulting from tight energy budgets during migration. Text Pipistrellus nathusii PubMed Central (PMC) Scientific Reports 10 1 |
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Article Voigt, Christian C. Fritze, Marcus Lindecke, Oliver Costantini, David Pētersons, Gunārs Czirják, Gábor Á. The immune response of bats differs between pre-migration and migration seasons |
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Maintaining a competent immune system is energetically costly and thus immunity may be traded against other costly traits such as seasonal migration. Here, we tested in long-distance migratory Nathusius’ pipistrelles (Pipistrellus nathusii), if selected branches of immunity are expressed differently in response to the energy demands and oxidative stress of aerial migration. During the migration period, we observed higher baseline lymphocyte and lower neutrophil levels than during the pre-migration period, but no stronger response of cellular effectors to an antigen challenge. Baseline plasma haptoglobin, as a component of the humoral innate immunity, remained similar during both seasons, yet baseline plasma haptoglobin levels increased by a factor of 7.8 in migratory bats during an immune challenge, whereas they did not change during the pre-migration period. Oxidative stress was higher during migration than during pre-migration, yet there was no association between blood oxidative status and immune parameters, and immune challenge did not trigger any changes in oxidative stress, irrespective of season. Our findings suggest that humoral effectors of the acute phase response may play a stronger role in the first-line defense against infections for migrating bats compared to non-migrating bats. We conclude that Nathusius’ pipistrelles allocate resources differently into the branches of their immune system, most likely following current demands resulting from tight energy budgets during migration. |
format |
Text |
author |
Voigt, Christian C. Fritze, Marcus Lindecke, Oliver Costantini, David Pētersons, Gunārs Czirják, Gábor Á. |
author_facet |
Voigt, Christian C. Fritze, Marcus Lindecke, Oliver Costantini, David Pētersons, Gunārs Czirják, Gábor Á. |
author_sort |
Voigt, Christian C. |
title |
The immune response of bats differs between pre-migration and migration seasons |
title_short |
The immune response of bats differs between pre-migration and migration seasons |
title_full |
The immune response of bats differs between pre-migration and migration seasons |
title_fullStr |
The immune response of bats differs between pre-migration and migration seasons |
title_full_unstemmed |
The immune response of bats differs between pre-migration and migration seasons |
title_sort |
immune response of bats differs between pre-migration and migration seasons |
publisher |
Nature Publishing Group UK |
publishDate |
2020 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7562910/ http://www.ncbi.nlm.nih.gov/pubmed/33060711 https://doi.org/10.1038/s41598-020-74473-3 |
genre |
Pipistrellus nathusii |
genre_facet |
Pipistrellus nathusii |
op_source |
Sci Rep |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7562910/ http://www.ncbi.nlm.nih.gov/pubmed/33060711 http://dx.doi.org/10.1038/s41598-020-74473-3 |
op_rights |
© The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1038/s41598-020-74473-3 |
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Scientific Reports |
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10 |
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