4CPS-237 Clinically-relevant drug-drug interactions among elderly people with dementia living in northern sweden
BACKGROUND: The prevalence of drug-related problems increases with age. One important cause is drug-drug interactions, which contribute to hospital admissions among the elderly. Elderly people with dementia are particularly vulnerable. PURPOSE: The aim of the present study was to assess the occurren...
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ftpubmed:oai:pubmedcentral.nih.gov:7535728 2023-05-15T17:44:32+02:00 4CPS-237 Clinically-relevant drug-drug interactions among elderly people with dementia living in northern sweden Sönnerstam, E Sjölander, M Gustafsson, M 2018-03-02 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7535728/ https://doi.org/10.1136/ejhpharm-2018-eahpconf.327 en eng BMJ Group http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7535728/ http://dx.doi.org/10.1136/ejhpharm-2018-eahpconf.327 © 2018, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions Eur J Hosp Pharm Section 4: Clinical pharmacy services Text 2018 ftpubmed https://doi.org/10.1136/ejhpharm-2018-eahpconf.327 2020-10-11T00:32:32Z BACKGROUND: The prevalence of drug-related problems increases with age. One important cause is drug-drug interactions, which contribute to hospital admissions among the elderly. Elderly people with dementia are particularly vulnerable. PURPOSE: The aim of the present study was to assess the occurrence and characteristics of drug-drug interactions and to investigate potential risk factors among elderly people with dementia. MATERIAL AND METHODS: Medical records of 458 people aged ≥65 years, with dementia or cognitive impairment that were admitted to two hospitals in northern Sweden between 9 January 2012 and 2 December 2014, were reviewed retrospectively. Information on medication use at the time of admission was collected. Clinically-relevant drug-drug interactions requiring either dose adjustments or avoidance of concomitant use were identified using the Janusmed interactions database. Interactions were further classified regarding pharmacological mechanism, i.e. pharmacokinetic or pharmacodynamic interactions and their subdivisions, according to Stockley’s classification system. Descriptive statistics and simple and multiple logistic regressions were used to analyse data. RESULTS: Four hundred and one drug-drug interactions were identified and 43.2% of the persons had at least one interaction. This is in line with, or somewhat higher than, results shown in other studies. In 95.8% of cases interactions required dose adjustment and in 4.2% of cases it was considered that the drug combination should be avoided. Pharmacokinetic interactions were most frequently observed of which warfarin – acetaminophen (n=26) was most common. Among pharmacodynamic interactions, furosemide – citalopram (n=35) and acetylsalicylic acid – citalopram (n=32) were the most frequently observed. An association was found in the multivariable model between the number of medications prescribed in the individual patient and the risk of one or more drug-drug interaction (OR 1.312, 95% CI: 1.227 to 1.403). No associations were found between ... Text Northern Sweden PubMed Central (PMC) Section 4: Clinical pharmacy services A151.2 A152 |
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Section 4: Clinical pharmacy services Sönnerstam, E Sjölander, M Gustafsson, M 4CPS-237 Clinically-relevant drug-drug interactions among elderly people with dementia living in northern sweden |
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Section 4: Clinical pharmacy services |
description |
BACKGROUND: The prevalence of drug-related problems increases with age. One important cause is drug-drug interactions, which contribute to hospital admissions among the elderly. Elderly people with dementia are particularly vulnerable. PURPOSE: The aim of the present study was to assess the occurrence and characteristics of drug-drug interactions and to investigate potential risk factors among elderly people with dementia. MATERIAL AND METHODS: Medical records of 458 people aged ≥65 years, with dementia or cognitive impairment that were admitted to two hospitals in northern Sweden between 9 January 2012 and 2 December 2014, were reviewed retrospectively. Information on medication use at the time of admission was collected. Clinically-relevant drug-drug interactions requiring either dose adjustments or avoidance of concomitant use were identified using the Janusmed interactions database. Interactions were further classified regarding pharmacological mechanism, i.e. pharmacokinetic or pharmacodynamic interactions and their subdivisions, according to Stockley’s classification system. Descriptive statistics and simple and multiple logistic regressions were used to analyse data. RESULTS: Four hundred and one drug-drug interactions were identified and 43.2% of the persons had at least one interaction. This is in line with, or somewhat higher than, results shown in other studies. In 95.8% of cases interactions required dose adjustment and in 4.2% of cases it was considered that the drug combination should be avoided. Pharmacokinetic interactions were most frequently observed of which warfarin – acetaminophen (n=26) was most common. Among pharmacodynamic interactions, furosemide – citalopram (n=35) and acetylsalicylic acid – citalopram (n=32) were the most frequently observed. An association was found in the multivariable model between the number of medications prescribed in the individual patient and the risk of one or more drug-drug interaction (OR 1.312, 95% CI: 1.227 to 1.403). No associations were found between ... |
format |
Text |
author |
Sönnerstam, E Sjölander, M Gustafsson, M |
author_facet |
Sönnerstam, E Sjölander, M Gustafsson, M |
author_sort |
Sönnerstam, E |
title |
4CPS-237 Clinically-relevant drug-drug interactions among elderly people with dementia living in northern sweden |
title_short |
4CPS-237 Clinically-relevant drug-drug interactions among elderly people with dementia living in northern sweden |
title_full |
4CPS-237 Clinically-relevant drug-drug interactions among elderly people with dementia living in northern sweden |
title_fullStr |
4CPS-237 Clinically-relevant drug-drug interactions among elderly people with dementia living in northern sweden |
title_full_unstemmed |
4CPS-237 Clinically-relevant drug-drug interactions among elderly people with dementia living in northern sweden |
title_sort |
4cps-237 clinically-relevant drug-drug interactions among elderly people with dementia living in northern sweden |
publisher |
BMJ Group |
publishDate |
2018 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7535728/ https://doi.org/10.1136/ejhpharm-2018-eahpconf.327 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_source |
Eur J Hosp Pharm |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7535728/ http://dx.doi.org/10.1136/ejhpharm-2018-eahpconf.327 |
op_rights |
© 2018, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions |
op_doi |
https://doi.org/10.1136/ejhpharm-2018-eahpconf.327 |
container_title |
Section 4: Clinical pharmacy services |
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A151.2 |
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A152 |
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1766146777744932864 |