Cohort profile: health effects monitoring programme in Ndilǫ, Dettah and Yellowknife (YKHEMP)
PURPOSE: The Yellowknife Health Effects Monitoring Programme (YKHEMP) was established to examine the relationship of exposure to arsenic and other chemicals of potential concern such as antimony, cadmium, lead, manganese and vanadium and health outcomes. PARTICIPANTS: A total of 2037 individuals wer...
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ftpubmed:oai:pubmedcentral.nih.gov:7523220 2023-05-15T17:46:45+02:00 Cohort profile: health effects monitoring programme in Ndilǫ, Dettah and Yellowknife (YKHEMP) Chan, Hing Man Hu, Xue Feng Cheung, Janet S. Parajuli, Rajendra Prasad Rosol, Renata Yumvihoze, Emmanuel Williams, Linna Mohapatra, Asish 2020-09-28 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7523220/ http://www.ncbi.nlm.nih.gov/pubmed/32988947 https://doi.org/10.1136/bmjopen-2020-038507 en eng BMJ Publishing Group http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7523220/ http://www.ncbi.nlm.nih.gov/pubmed/32988947 http://dx.doi.org/10.1136/bmjopen-2020-038507 © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/. CC-BY-NC BMJ Open Epidemiology Text 2020 ftpubmed https://doi.org/10.1136/bmjopen-2020-038507 2020-10-18T00:20:47Z PURPOSE: The Yellowknife Health Effects Monitoring Programme (YKHEMP) was established to examine the relationship of exposure to arsenic and other chemicals of potential concern such as antimony, cadmium, lead, manganese and vanadium and health outcomes. PARTICIPANTS: A total of 2037 individuals were recruited, including children (age 3–19) and adults (age 20+), residing in Dettah, Ndilǫ and Yellowknife, in the Northwest Territories, Canada, in two waves in Fall 2017 and Spring 2018. In Yellowknife, there were 891 (675 adults, 216 children), randomly selected participants with a participation rate of 64%. In addition, we also recruited a total of 875 (669 adults, 206 children) volunteer participants. A total of 225 (137 adults, 88 children) of the Yellowknives Dene First Nation (YKDFN), and 46 (33 adults, 13 children) of the North Slave Métis Alliance participated in the study. Each participant answered a lifestyle questionnaire as well as provided toenail clippings and urine for contaminant testing and saliva samples for testing of genetic polymorphisms associated with arsenic metabolism. Participants also provided consent to have their medical records reviewed by the research team for the past 5 years to allow for the investigation between exposure and health outcomes. FINDINGS TO DATE: The adult YKHEMP participants had lower urinary total arsenic but the children had higher inorganic arsenic than the general Canadian population. There was no difference in urinary total arsenic concentrations between adults and children, however, urinary inorganic arsenic concentrations were generally higher in children than in adults in all four YKHEMP sampling groups. The adult YKDFN participants had lower urinary total arsenic and inorganic arsenic concentrations compared with the random selected and volunteer participants. FUTURE PLANS: YKHEMP is designed as a prospective cohort study; the children participants will be re-examined in 2022 and both adult and children participants in 2027. Text Northwest Territories Yellowknife PubMed Central (PMC) Canada Dettah ENVELOPE(-114.307,-114.307,62.412,62.412) Northwest Territories Yellowknife BMJ Open 10 9 e038507 |
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Epidemiology |
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Epidemiology Chan, Hing Man Hu, Xue Feng Cheung, Janet S. Parajuli, Rajendra Prasad Rosol, Renata Yumvihoze, Emmanuel Williams, Linna Mohapatra, Asish Cohort profile: health effects monitoring programme in Ndilǫ, Dettah and Yellowknife (YKHEMP) |
topic_facet |
Epidemiology |
description |
PURPOSE: The Yellowknife Health Effects Monitoring Programme (YKHEMP) was established to examine the relationship of exposure to arsenic and other chemicals of potential concern such as antimony, cadmium, lead, manganese and vanadium and health outcomes. PARTICIPANTS: A total of 2037 individuals were recruited, including children (age 3–19) and adults (age 20+), residing in Dettah, Ndilǫ and Yellowknife, in the Northwest Territories, Canada, in two waves in Fall 2017 and Spring 2018. In Yellowknife, there were 891 (675 adults, 216 children), randomly selected participants with a participation rate of 64%. In addition, we also recruited a total of 875 (669 adults, 206 children) volunteer participants. A total of 225 (137 adults, 88 children) of the Yellowknives Dene First Nation (YKDFN), and 46 (33 adults, 13 children) of the North Slave Métis Alliance participated in the study. Each participant answered a lifestyle questionnaire as well as provided toenail clippings and urine for contaminant testing and saliva samples for testing of genetic polymorphisms associated with arsenic metabolism. Participants also provided consent to have their medical records reviewed by the research team for the past 5 years to allow for the investigation between exposure and health outcomes. FINDINGS TO DATE: The adult YKHEMP participants had lower urinary total arsenic but the children had higher inorganic arsenic than the general Canadian population. There was no difference in urinary total arsenic concentrations between adults and children, however, urinary inorganic arsenic concentrations were generally higher in children than in adults in all four YKHEMP sampling groups. The adult YKDFN participants had lower urinary total arsenic and inorganic arsenic concentrations compared with the random selected and volunteer participants. FUTURE PLANS: YKHEMP is designed as a prospective cohort study; the children participants will be re-examined in 2022 and both adult and children participants in 2027. |
format |
Text |
author |
Chan, Hing Man Hu, Xue Feng Cheung, Janet S. Parajuli, Rajendra Prasad Rosol, Renata Yumvihoze, Emmanuel Williams, Linna Mohapatra, Asish |
author_facet |
Chan, Hing Man Hu, Xue Feng Cheung, Janet S. Parajuli, Rajendra Prasad Rosol, Renata Yumvihoze, Emmanuel Williams, Linna Mohapatra, Asish |
author_sort |
Chan, Hing Man |
title |
Cohort profile: health effects monitoring programme in Ndilǫ, Dettah and Yellowknife (YKHEMP) |
title_short |
Cohort profile: health effects monitoring programme in Ndilǫ, Dettah and Yellowknife (YKHEMP) |
title_full |
Cohort profile: health effects monitoring programme in Ndilǫ, Dettah and Yellowknife (YKHEMP) |
title_fullStr |
Cohort profile: health effects monitoring programme in Ndilǫ, Dettah and Yellowknife (YKHEMP) |
title_full_unstemmed |
Cohort profile: health effects monitoring programme in Ndilǫ, Dettah and Yellowknife (YKHEMP) |
title_sort |
cohort profile: health effects monitoring programme in ndilǫ, dettah and yellowknife (ykhemp) |
publisher |
BMJ Publishing Group |
publishDate |
2020 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7523220/ http://www.ncbi.nlm.nih.gov/pubmed/32988947 https://doi.org/10.1136/bmjopen-2020-038507 |
long_lat |
ENVELOPE(-114.307,-114.307,62.412,62.412) |
geographic |
Canada Dettah Northwest Territories Yellowknife |
geographic_facet |
Canada Dettah Northwest Territories Yellowknife |
genre |
Northwest Territories Yellowknife |
genre_facet |
Northwest Territories Yellowknife |
op_source |
BMJ Open |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7523220/ http://www.ncbi.nlm.nih.gov/pubmed/32988947 http://dx.doi.org/10.1136/bmjopen-2020-038507 |
op_rights |
© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/. |
op_rightsnorm |
CC-BY-NC |
op_doi |
https://doi.org/10.1136/bmjopen-2020-038507 |
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