Early childhood and adolescent risk factors for psychotic depression in a general population birth cohort sample
BACKGROUND AND PURPOSE: In the group of severe mental disorders, psychotic depression (PD) is essentially under-researched. Knowledge about the risk factors is scarce and this applies especially to early risk factors. Our aim was to study early childhood and adolescent risk factors of PD in a repres...
Published in: | Social Psychiatry and Psychiatric Epidemiology |
---|---|
Main Authors: | , , , , , , |
Format: | Text |
Language: | English |
Published: |
Springer Berlin Heidelberg
2020
|
Subjects: | |
Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7471190/ http://www.ncbi.nlm.nih.gov/pubmed/32055894 https://doi.org/10.1007/s00127-020-01835-7 |
id |
ftpubmed:oai:pubmedcentral.nih.gov:7471190 |
---|---|
record_format |
openpolar |
spelling |
ftpubmed:oai:pubmedcentral.nih.gov:7471190 2023-05-15T17:42:46+02:00 Early childhood and adolescent risk factors for psychotic depression in a general population birth cohort sample Nietola, Miika Huovinen, Hanna Heiskala, Anni Nordström, Tanja Miettunen, Jouko Korkeila, Jyrki Jääskeläinen, Erika 2020-02-13 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7471190/ http://www.ncbi.nlm.nih.gov/pubmed/32055894 https://doi.org/10.1007/s00127-020-01835-7 en eng Springer Berlin Heidelberg http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7471190/ http://www.ncbi.nlm.nih.gov/pubmed/32055894 http://dx.doi.org/10.1007/s00127-020-01835-7 © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. CC-BY Soc Psychiatry Psychiatr Epidemiol Original Paper Text 2020 ftpubmed https://doi.org/10.1007/s00127-020-01835-7 2020-09-20T00:24:24Z BACKGROUND AND PURPOSE: In the group of severe mental disorders, psychotic depression (PD) is essentially under-researched. Knowledge about the risk factors is scarce and this applies especially to early risk factors. Our aim was to study early childhood and adolescent risk factors of PD in a representative birth cohort sample with a follow-up of up to 50 years. METHODS: The study was carried out using the Northern Finland Birth Cohort 1966 (NFBC 1966). We used non-psychotic depression (NPD) (n = 746), schizophrenia (SZ) (n = 195), psychotic bipolar disorder (PBD) (n = 27), other psychoses (PNOS) (n = 136) and healthy controls (HC) (n = 8200) as comparison groups for PD (n = 58). We analysed several potential early risk factors from time of birth until the age of 16 years. RESULTS: The main finding was that parents’ psychiatric illness [HR 3.59 (1.84–7.04)] was a risk factor and a high sports grade in school was a protective factor [HR 0.29 (0.11–0.73)] for PD also after adjusting for covariates in the multivariate Cox regression model. Parental psychotic illness was an especially strong risk factor for PD. The PD subjects had a parent with psychiatric illness significantly more often (p < 0.05) than NPD subjects. Differences between PD and other disorder groups were otherwise small. CONCLUSIONS: A low sports grade in school may be a risk factor for PD. Psychiatric illnesses, especially psychoses, are common in the parents of PD subjects. A surprisingly low number of statistically significant risk factors may have resulted from the size of the PD sample and the underlying heterogeneity of the etiology of PD. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00127-020-01835-7) contains supplementary material, which is available to authorized users. Text Northern Finland PubMed Central (PMC) Social Psychiatry and Psychiatric Epidemiology 55 9 1179 1186 |
institution |
Open Polar |
collection |
PubMed Central (PMC) |
op_collection_id |
ftpubmed |
language |
English |
topic |
Original Paper |
spellingShingle |
Original Paper Nietola, Miika Huovinen, Hanna Heiskala, Anni Nordström, Tanja Miettunen, Jouko Korkeila, Jyrki Jääskeläinen, Erika Early childhood and adolescent risk factors for psychotic depression in a general population birth cohort sample |
topic_facet |
Original Paper |
description |
BACKGROUND AND PURPOSE: In the group of severe mental disorders, psychotic depression (PD) is essentially under-researched. Knowledge about the risk factors is scarce and this applies especially to early risk factors. Our aim was to study early childhood and adolescent risk factors of PD in a representative birth cohort sample with a follow-up of up to 50 years. METHODS: The study was carried out using the Northern Finland Birth Cohort 1966 (NFBC 1966). We used non-psychotic depression (NPD) (n = 746), schizophrenia (SZ) (n = 195), psychotic bipolar disorder (PBD) (n = 27), other psychoses (PNOS) (n = 136) and healthy controls (HC) (n = 8200) as comparison groups for PD (n = 58). We analysed several potential early risk factors from time of birth until the age of 16 years. RESULTS: The main finding was that parents’ psychiatric illness [HR 3.59 (1.84–7.04)] was a risk factor and a high sports grade in school was a protective factor [HR 0.29 (0.11–0.73)] for PD also after adjusting for covariates in the multivariate Cox regression model. Parental psychotic illness was an especially strong risk factor for PD. The PD subjects had a parent with psychiatric illness significantly more often (p < 0.05) than NPD subjects. Differences between PD and other disorder groups were otherwise small. CONCLUSIONS: A low sports grade in school may be a risk factor for PD. Psychiatric illnesses, especially psychoses, are common in the parents of PD subjects. A surprisingly low number of statistically significant risk factors may have resulted from the size of the PD sample and the underlying heterogeneity of the etiology of PD. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00127-020-01835-7) contains supplementary material, which is available to authorized users. |
format |
Text |
author |
Nietola, Miika Huovinen, Hanna Heiskala, Anni Nordström, Tanja Miettunen, Jouko Korkeila, Jyrki Jääskeläinen, Erika |
author_facet |
Nietola, Miika Huovinen, Hanna Heiskala, Anni Nordström, Tanja Miettunen, Jouko Korkeila, Jyrki Jääskeläinen, Erika |
author_sort |
Nietola, Miika |
title |
Early childhood and adolescent risk factors for psychotic depression in a general population birth cohort sample |
title_short |
Early childhood and adolescent risk factors for psychotic depression in a general population birth cohort sample |
title_full |
Early childhood and adolescent risk factors for psychotic depression in a general population birth cohort sample |
title_fullStr |
Early childhood and adolescent risk factors for psychotic depression in a general population birth cohort sample |
title_full_unstemmed |
Early childhood and adolescent risk factors for psychotic depression in a general population birth cohort sample |
title_sort |
early childhood and adolescent risk factors for psychotic depression in a general population birth cohort sample |
publisher |
Springer Berlin Heidelberg |
publishDate |
2020 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7471190/ http://www.ncbi.nlm.nih.gov/pubmed/32055894 https://doi.org/10.1007/s00127-020-01835-7 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_source |
Soc Psychiatry Psychiatr Epidemiol |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7471190/ http://www.ncbi.nlm.nih.gov/pubmed/32055894 http://dx.doi.org/10.1007/s00127-020-01835-7 |
op_rights |
© The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1007/s00127-020-01835-7 |
container_title |
Social Psychiatry and Psychiatric Epidemiology |
container_volume |
55 |
container_issue |
9 |
container_start_page |
1179 |
op_container_end_page |
1186 |
_version_ |
1766144674265825280 |