Cancer Risk After Bariatric Surgery in a Cohort Study from the Five Nordic Countries
PURPOSE: Obesity increases the risk of several cancers, but the influence of bariatric surgery on the risk of individual obesity-related cancers is unclear. This study aimed to assess the impact of bariatric surgery on cancer risk in a multi-national setting. MATERIALS AND METHODS: This cohort study...
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ftpubmed:oai:pubmedcentral.nih.gov:7467909 2023-05-15T16:51:50+02:00 Cancer Risk After Bariatric Surgery in a Cohort Study from the Five Nordic Countries Tao, Wenjing Santoni, Giola von Euler-Chelpin, My Ljung, Rickard Lynge, Elsebeth Pukkala, Eero Ness-Jensen, Eivind Romundstad, Pål Tryggvadottir, Laufey Lagergren, Jesper 2020-06-13 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7467909/ http://www.ncbi.nlm.nih.gov/pubmed/32535785 https://doi.org/10.1007/s11695-020-04751-6 en eng Springer US http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7467909/ http://www.ncbi.nlm.nih.gov/pubmed/32535785 http://dx.doi.org/10.1007/s11695-020-04751-6 © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. CC-BY Obes Surg Original Contributions Text 2020 ftpubmed https://doi.org/10.1007/s11695-020-04751-6 2020-09-20T00:22:36Z PURPOSE: Obesity increases the risk of several cancers, but the influence of bariatric surgery on the risk of individual obesity-related cancers is unclear. This study aimed to assess the impact of bariatric surgery on cancer risk in a multi-national setting. MATERIALS AND METHODS: This cohort study included all adults with an obesity diagnosis identified from national patient registries in all Nordic countries (Denmark, Finland, Iceland, Norway and Sweden) from 1980 to 2012. Cancer risk in bariatric surgery patients was compared with non-operated patients with obesity. Multivariable Cox regression provided adjusted hazard ratios (HRs) with 95% confidence intervals (CIs). Age, sex, calendar year, country, length of follow-up, diabetes, chronic obstructive pulmonary disease and alcohol-related diseases were evaluated as confounders. RESULTS: Among 482,572 participants with obesity, 49,096 underwent bariatric surgery. Bariatric surgery was followed by a decreased overall cancer risk in women (HR 0.86, 95% CI 0.80–0.92), but not in men (HR 0.98, 95% CI 0.95–1.01). The risk reduction was observed only within the first five post-operative years. Among specific tumours, HRs decreased for breast cancer (HR 0.81, 95% CI 0.69–0.95), endometrial cancer (HR 0.69, 95% CI 0.56–0.84) and non-Hodgkin lymphoma (HR 0.64, 95% CI 0.42–0.97) in female bariatric surgery patients, while the risk of kidney cancer increased in both sexes (HR 1.44, 95% CI 1.13–1.84). CONCLUSION: Bariatric surgery may decrease overall cancer risk in women within the first five years after surgery. This decrease may be explained by a decreased risk of breast and endometrial cancer and non-Hodgkin lymphoma in women. Text Iceland PubMed Central (PMC) Norway Obesity Surgery 30 10 3761 3767 |
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Original Contributions Tao, Wenjing Santoni, Giola von Euler-Chelpin, My Ljung, Rickard Lynge, Elsebeth Pukkala, Eero Ness-Jensen, Eivind Romundstad, Pål Tryggvadottir, Laufey Lagergren, Jesper Cancer Risk After Bariatric Surgery in a Cohort Study from the Five Nordic Countries |
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Original Contributions |
description |
PURPOSE: Obesity increases the risk of several cancers, but the influence of bariatric surgery on the risk of individual obesity-related cancers is unclear. This study aimed to assess the impact of bariatric surgery on cancer risk in a multi-national setting. MATERIALS AND METHODS: This cohort study included all adults with an obesity diagnosis identified from national patient registries in all Nordic countries (Denmark, Finland, Iceland, Norway and Sweden) from 1980 to 2012. Cancer risk in bariatric surgery patients was compared with non-operated patients with obesity. Multivariable Cox regression provided adjusted hazard ratios (HRs) with 95% confidence intervals (CIs). Age, sex, calendar year, country, length of follow-up, diabetes, chronic obstructive pulmonary disease and alcohol-related diseases were evaluated as confounders. RESULTS: Among 482,572 participants with obesity, 49,096 underwent bariatric surgery. Bariatric surgery was followed by a decreased overall cancer risk in women (HR 0.86, 95% CI 0.80–0.92), but not in men (HR 0.98, 95% CI 0.95–1.01). The risk reduction was observed only within the first five post-operative years. Among specific tumours, HRs decreased for breast cancer (HR 0.81, 95% CI 0.69–0.95), endometrial cancer (HR 0.69, 95% CI 0.56–0.84) and non-Hodgkin lymphoma (HR 0.64, 95% CI 0.42–0.97) in female bariatric surgery patients, while the risk of kidney cancer increased in both sexes (HR 1.44, 95% CI 1.13–1.84). CONCLUSION: Bariatric surgery may decrease overall cancer risk in women within the first five years after surgery. This decrease may be explained by a decreased risk of breast and endometrial cancer and non-Hodgkin lymphoma in women. |
format |
Text |
author |
Tao, Wenjing Santoni, Giola von Euler-Chelpin, My Ljung, Rickard Lynge, Elsebeth Pukkala, Eero Ness-Jensen, Eivind Romundstad, Pål Tryggvadottir, Laufey Lagergren, Jesper |
author_facet |
Tao, Wenjing Santoni, Giola von Euler-Chelpin, My Ljung, Rickard Lynge, Elsebeth Pukkala, Eero Ness-Jensen, Eivind Romundstad, Pål Tryggvadottir, Laufey Lagergren, Jesper |
author_sort |
Tao, Wenjing |
title |
Cancer Risk After Bariatric Surgery in a Cohort Study from the Five Nordic Countries |
title_short |
Cancer Risk After Bariatric Surgery in a Cohort Study from the Five Nordic Countries |
title_full |
Cancer Risk After Bariatric Surgery in a Cohort Study from the Five Nordic Countries |
title_fullStr |
Cancer Risk After Bariatric Surgery in a Cohort Study from the Five Nordic Countries |
title_full_unstemmed |
Cancer Risk After Bariatric Surgery in a Cohort Study from the Five Nordic Countries |
title_sort |
cancer risk after bariatric surgery in a cohort study from the five nordic countries |
publisher |
Springer US |
publishDate |
2020 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7467909/ http://www.ncbi.nlm.nih.gov/pubmed/32535785 https://doi.org/10.1007/s11695-020-04751-6 |
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Norway |
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Norway |
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Iceland |
genre_facet |
Iceland |
op_source |
Obes Surg |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7467909/ http://www.ncbi.nlm.nih.gov/pubmed/32535785 http://dx.doi.org/10.1007/s11695-020-04751-6 |
op_rights |
© The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1007/s11695-020-04751-6 |
container_title |
Obesity Surgery |
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30 |
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10 |
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3761 |
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3767 |
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1766041952286932992 |