Quantitative Evaluation of Meniscal Healing Process of Degenerative Meniscus Lesions Treated with Hyaluronic Acid: A Clinical and MRI Study
Purpose: We aimed to evaluate clinical efficacy and healing effects of conservative management of degenerative meniscus lesions (DMLs) with a hyaluronic acid (HA) hydrogel. Methods: Patients were subjected to two HA injections two weeks apart. Western Ontario and McMaster Universities Osteoarthritis...
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ftpubmed:oai:pubmedcentral.nih.gov:7408658 2023-05-15T16:02:06+02:00 Quantitative Evaluation of Meniscal Healing Process of Degenerative Meniscus Lesions Treated with Hyaluronic Acid: A Clinical and MRI Study Berton, Alessandra Longo, Umile Giuseppe Candela, Vincenzo Greco, Federico Martina, Francesca Maria Quattrocchi, Carlo Cosimo Denaro, Vincenzo 2020-07-17 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408658/ http://www.ncbi.nlm.nih.gov/pubmed/32709084 https://doi.org/10.3390/jcm9072280 en eng MDPI http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408658/ http://www.ncbi.nlm.nih.gov/pubmed/32709084 http://dx.doi.org/10.3390/jcm9072280 © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). CC-BY J Clin Med Article Text 2020 ftpubmed https://doi.org/10.3390/jcm9072280 2020-08-16T00:32:00Z Purpose: We aimed to evaluate clinical efficacy and healing effects of conservative management of degenerative meniscus lesions (DMLs) with a hyaluronic acid (HA) hydrogel. Methods: Patients were subjected to two HA injections two weeks apart. Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Patient’s Global Assessment (PtGA) and Clinical Observer Global Assessment (CoGA) of the disease were assessed at baseline, 30, and 60 days after treatment. Short Form (36) Health Survey (SF-36) was assessed at baseline and 60 days after treatment. One year after treatment, patients were called to know whether any of them had undergone arthroscopic partial meniscectomy (APM). All patients underwent magnetic resonance imaging using a 1.5-T Magnetic Resonance Imaging (MRI) scanner (Siemens Aera), which included a T2 mapping pulse sequence with multiple echoes at baseline and 60 days after treatment. Results: 40 patients were enrolled. WOMAC score, physical function subscale, PtGA and CoGA, and SF-36 showed a statistically significant difference between baseline and follow-up. One year after treatment, only one patient had undergone APM. A decrease in the T2 measurement was detected in the posterior horn medial meniscus in 39% of cases in both the red and red–white zone, and in 60% of cases in the white zone; in the posterior horn lateral meniscus in 55% of cases in both the red and white zones, and in 65% of cases in the red–white zone. Only for the latter, there was a statistically significant difference between baseline and posttreatment T2 measurements. Conclusion: This study supports the use of HA in the conservative management of DML as it is clinically effective and enhances meniscus healing as demonstrated by T2 measurements. Moreover, it reduces the need for APM at 1-year follow-up. Text DML PubMed Central (PMC) Journal of Clinical Medicine 9 7 2280 |
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Article Berton, Alessandra Longo, Umile Giuseppe Candela, Vincenzo Greco, Federico Martina, Francesca Maria Quattrocchi, Carlo Cosimo Denaro, Vincenzo Quantitative Evaluation of Meniscal Healing Process of Degenerative Meniscus Lesions Treated with Hyaluronic Acid: A Clinical and MRI Study |
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Article |
description |
Purpose: We aimed to evaluate clinical efficacy and healing effects of conservative management of degenerative meniscus lesions (DMLs) with a hyaluronic acid (HA) hydrogel. Methods: Patients were subjected to two HA injections two weeks apart. Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Patient’s Global Assessment (PtGA) and Clinical Observer Global Assessment (CoGA) of the disease were assessed at baseline, 30, and 60 days after treatment. Short Form (36) Health Survey (SF-36) was assessed at baseline and 60 days after treatment. One year after treatment, patients were called to know whether any of them had undergone arthroscopic partial meniscectomy (APM). All patients underwent magnetic resonance imaging using a 1.5-T Magnetic Resonance Imaging (MRI) scanner (Siemens Aera), which included a T2 mapping pulse sequence with multiple echoes at baseline and 60 days after treatment. Results: 40 patients were enrolled. WOMAC score, physical function subscale, PtGA and CoGA, and SF-36 showed a statistically significant difference between baseline and follow-up. One year after treatment, only one patient had undergone APM. A decrease in the T2 measurement was detected in the posterior horn medial meniscus in 39% of cases in both the red and red–white zone, and in 60% of cases in the white zone; in the posterior horn lateral meniscus in 55% of cases in both the red and white zones, and in 65% of cases in the red–white zone. Only for the latter, there was a statistically significant difference between baseline and posttreatment T2 measurements. Conclusion: This study supports the use of HA in the conservative management of DML as it is clinically effective and enhances meniscus healing as demonstrated by T2 measurements. Moreover, it reduces the need for APM at 1-year follow-up. |
format |
Text |
author |
Berton, Alessandra Longo, Umile Giuseppe Candela, Vincenzo Greco, Federico Martina, Francesca Maria Quattrocchi, Carlo Cosimo Denaro, Vincenzo |
author_facet |
Berton, Alessandra Longo, Umile Giuseppe Candela, Vincenzo Greco, Federico Martina, Francesca Maria Quattrocchi, Carlo Cosimo Denaro, Vincenzo |
author_sort |
Berton, Alessandra |
title |
Quantitative Evaluation of Meniscal Healing Process of Degenerative Meniscus Lesions Treated with Hyaluronic Acid: A Clinical and MRI Study |
title_short |
Quantitative Evaluation of Meniscal Healing Process of Degenerative Meniscus Lesions Treated with Hyaluronic Acid: A Clinical and MRI Study |
title_full |
Quantitative Evaluation of Meniscal Healing Process of Degenerative Meniscus Lesions Treated with Hyaluronic Acid: A Clinical and MRI Study |
title_fullStr |
Quantitative Evaluation of Meniscal Healing Process of Degenerative Meniscus Lesions Treated with Hyaluronic Acid: A Clinical and MRI Study |
title_full_unstemmed |
Quantitative Evaluation of Meniscal Healing Process of Degenerative Meniscus Lesions Treated with Hyaluronic Acid: A Clinical and MRI Study |
title_sort |
quantitative evaluation of meniscal healing process of degenerative meniscus lesions treated with hyaluronic acid: a clinical and mri study |
publisher |
MDPI |
publishDate |
2020 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408658/ http://www.ncbi.nlm.nih.gov/pubmed/32709084 https://doi.org/10.3390/jcm9072280 |
genre |
DML |
genre_facet |
DML |
op_source |
J Clin Med |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408658/ http://www.ncbi.nlm.nih.gov/pubmed/32709084 http://dx.doi.org/10.3390/jcm9072280 |
op_rights |
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.3390/jcm9072280 |
container_title |
Journal of Clinical Medicine |
container_volume |
9 |
container_issue |
7 |
container_start_page |
2280 |
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