Sea cucumber Cucumaria frondosa fucoidan inhibits osteosarcoma adhesion and migration by regulating cytoskeleton remodeling
Osteosarcoma (OS) has been demonstrated to be difficult to cure due to its potently malignant metastasis. Therefore, new therapeutic approaches blocking the metastatic potential of OS are urgently required to improve the outcomes for OS patients. In the present study, the anti-metastatic capacity of...
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Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336482/ http://www.ncbi.nlm.nih.gov/pubmed/32467988 https://doi.org/10.3892/or.2020.7614 |
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ftpubmed:oai:pubmedcentral.nih.gov:7336482 2023-05-15T15:59:37+02:00 Sea cucumber Cucumaria frondosa fucoidan inhibits osteosarcoma adhesion and migration by regulating cytoskeleton remodeling Zhang, Minglei Chen, Li Liu, Yang Chen, Minghui Zhang, Shuang Kong, Daliang 2020-08 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336482/ http://www.ncbi.nlm.nih.gov/pubmed/32467988 https://doi.org/10.3892/or.2020.7614 en eng D.A. Spandidos http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336482/ http://www.ncbi.nlm.nih.gov/pubmed/32467988 http://dx.doi.org/10.3892/or.2020.7614 Copyright: © Zhang et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. CC-BY-NC-ND Oncol Rep Articles Text 2020 ftpubmed https://doi.org/10.3892/or.2020.7614 2020-07-12T00:37:09Z Osteosarcoma (OS) has been demonstrated to be difficult to cure due to its potently malignant metastasis. Therefore, new therapeutic approaches blocking the metastatic potential of OS are urgently required to improve the outcomes for OS patients. In the present study, the anti-metastatic capacity of sea cucumber (Cucumaria frondosa) fucoidan (Cf-Fuc) was evaluated on osteosarcoma cells by cell adhesion assay, Transwell assay and U2OS cell migration assay. The underlying mechanism on the dynamic remodeling of the cytoskeleton was also explored. The present data indicated that Cf-Fuc could block the U2OS osteosarcoma cell adhesion to fibronectin and significantly inhibit U2OS cell migration. Cf-Fuc greatly impaired the migration capacity of U2OS cells, and the migrated distance and velocity of Cf-Fuc-treated cells were markedly reduced. Also, Cf-Fuc could impair the dynamic remodeling of the cytoskeleton possibly by suppressing the phosphorylation of focal adhesion kinase and paxillin, as well as the activation of the Rac1/PAK1/LIMK1/cofilin signaling axis. Collectively, the present findings provide a novel therapeutic potential of C. frondosa fucoidan for osteosarcoma metastasis. Text Cucumaria frondosa PubMed Central (PMC) Oncology Reports 44 2 469 476 |
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Articles Zhang, Minglei Chen, Li Liu, Yang Chen, Minghui Zhang, Shuang Kong, Daliang Sea cucumber Cucumaria frondosa fucoidan inhibits osteosarcoma adhesion and migration by regulating cytoskeleton remodeling |
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Articles |
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Osteosarcoma (OS) has been demonstrated to be difficult to cure due to its potently malignant metastasis. Therefore, new therapeutic approaches blocking the metastatic potential of OS are urgently required to improve the outcomes for OS patients. In the present study, the anti-metastatic capacity of sea cucumber (Cucumaria frondosa) fucoidan (Cf-Fuc) was evaluated on osteosarcoma cells by cell adhesion assay, Transwell assay and U2OS cell migration assay. The underlying mechanism on the dynamic remodeling of the cytoskeleton was also explored. The present data indicated that Cf-Fuc could block the U2OS osteosarcoma cell adhesion to fibronectin and significantly inhibit U2OS cell migration. Cf-Fuc greatly impaired the migration capacity of U2OS cells, and the migrated distance and velocity of Cf-Fuc-treated cells were markedly reduced. Also, Cf-Fuc could impair the dynamic remodeling of the cytoskeleton possibly by suppressing the phosphorylation of focal adhesion kinase and paxillin, as well as the activation of the Rac1/PAK1/LIMK1/cofilin signaling axis. Collectively, the present findings provide a novel therapeutic potential of C. frondosa fucoidan for osteosarcoma metastasis. |
format |
Text |
author |
Zhang, Minglei Chen, Li Liu, Yang Chen, Minghui Zhang, Shuang Kong, Daliang |
author_facet |
Zhang, Minglei Chen, Li Liu, Yang Chen, Minghui Zhang, Shuang Kong, Daliang |
author_sort |
Zhang, Minglei |
title |
Sea cucumber Cucumaria frondosa fucoidan inhibits osteosarcoma adhesion and migration by regulating cytoskeleton remodeling |
title_short |
Sea cucumber Cucumaria frondosa fucoidan inhibits osteosarcoma adhesion and migration by regulating cytoskeleton remodeling |
title_full |
Sea cucumber Cucumaria frondosa fucoidan inhibits osteosarcoma adhesion and migration by regulating cytoskeleton remodeling |
title_fullStr |
Sea cucumber Cucumaria frondosa fucoidan inhibits osteosarcoma adhesion and migration by regulating cytoskeleton remodeling |
title_full_unstemmed |
Sea cucumber Cucumaria frondosa fucoidan inhibits osteosarcoma adhesion and migration by regulating cytoskeleton remodeling |
title_sort |
sea cucumber cucumaria frondosa fucoidan inhibits osteosarcoma adhesion and migration by regulating cytoskeleton remodeling |
publisher |
D.A. Spandidos |
publishDate |
2020 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336482/ http://www.ncbi.nlm.nih.gov/pubmed/32467988 https://doi.org/10.3892/or.2020.7614 |
genre |
Cucumaria frondosa |
genre_facet |
Cucumaria frondosa |
op_source |
Oncol Rep |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336482/ http://www.ncbi.nlm.nih.gov/pubmed/32467988 http://dx.doi.org/10.3892/or.2020.7614 |
op_rights |
Copyright: © Zhang et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
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CC-BY-NC-ND |
op_doi |
https://doi.org/10.3892/or.2020.7614 |
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Oncology Reports |
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44 |
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2 |
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469 |
op_container_end_page |
476 |
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1766395553353039872 |