Unique fatty acid desaturase capacities uncovered in Hediste diversicolor illustrate the roles of aquatic invertebrates in trophic upgrading
Omega-3 (ω3 or n-3) long-chain polyunsaturated fatty acids (PUFA), including eicosapentaenoic acid and docosahexaenoic acid (DHA), play physiologically important roles in vertebrates. These compounds have long been believed to have originated almost exclusively from aquatic (mostly marine) single-ce...
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ftpubmed:oai:pubmedcentral.nih.gov:7333967 2023-05-15T17:34:42+02:00 Unique fatty acid desaturase capacities uncovered in Hediste diversicolor illustrate the roles of aquatic invertebrates in trophic upgrading Kabeya, Naoki Gür, İbrahim Oboh, Angela Evjemo, Jan Ove Malzahn, Arne M. Hontoria, Francisco Navarro, Juan C. Monroig, Óscar 2020-08-03 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333967/ http://www.ncbi.nlm.nih.gov/pubmed/32536307 https://doi.org/10.1098/rstb.2019.0654 en eng The Royal Society http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333967/ http://www.ncbi.nlm.nih.gov/pubmed/32536307 http://dx.doi.org/10.1098/rstb.2019.0654 © 2020 The Author(s) https://royalsociety.org/-/media/journals/author/Licence-to-Publish-20062019-final.pdfhttps://royalsociety.org/journals/ethics-policies/data-sharing-mining/Published by the Royal Society. All rights reserved. Philos Trans R Soc Lond B Biol Sci Articles Text 2020 ftpubmed https://doi.org/10.1098/rstb.2019.0654 2021-08-08T00:21:56Z Omega-3 (ω3 or n-3) long-chain polyunsaturated fatty acids (PUFA), including eicosapentaenoic acid and docosahexaenoic acid (DHA), play physiologically important roles in vertebrates. These compounds have long been believed to have originated almost exclusively from aquatic (mostly marine) single-cell organisms. Yet, a recent study has discovered that many invertebrates possess a type of enzymes called methyl-end desaturases (ωx) that enables them to endogenously produce n-3 long-chain PUFA and could make a significant contribution to production of these compounds in the marine environment. Polychaetes are major components of benthic fauna and thus important to maintain a robust food web as a recycler of organic matter and a prey item for higher trophic level species like fish. In the present study, we investigated the ωx enzymes from the common ragworm, Hediste diversicolor, a common inhabitant in sedimentary littoral ecosystems of the North Atlantic. Functional assays of the H. diversicolor ωx demonstrated unique desaturation capacities. An ω3 desaturase mediated the conversion of n-6 fatty acid substrates into their corresponding n-3 products including DHA. A further enzyme possessed unique regioselectivities combining both ω6 and ω3 desaturase activities. These results illustrate that the long-chain PUFA biosynthetic enzymatic machinery of aquatic invertebrates such as polychaetes is highly diverse and clarify that invertebrates can be major contributors to fatty acid trophic upgrading in aquatic food webs. This article is part of the theme issue ‘The next horizons for lipids as ‘trophic biomarkers’: evidence and significance of consumer modification of dietary fatty acids’. Text North Atlantic PubMed Central (PMC) Philosophical Transactions of the Royal Society B: Biological Sciences 375 1804 20190654 |
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Articles Kabeya, Naoki Gür, İbrahim Oboh, Angela Evjemo, Jan Ove Malzahn, Arne M. Hontoria, Francisco Navarro, Juan C. Monroig, Óscar Unique fatty acid desaturase capacities uncovered in Hediste diversicolor illustrate the roles of aquatic invertebrates in trophic upgrading |
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Articles |
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Omega-3 (ω3 or n-3) long-chain polyunsaturated fatty acids (PUFA), including eicosapentaenoic acid and docosahexaenoic acid (DHA), play physiologically important roles in vertebrates. These compounds have long been believed to have originated almost exclusively from aquatic (mostly marine) single-cell organisms. Yet, a recent study has discovered that many invertebrates possess a type of enzymes called methyl-end desaturases (ωx) that enables them to endogenously produce n-3 long-chain PUFA and could make a significant contribution to production of these compounds in the marine environment. Polychaetes are major components of benthic fauna and thus important to maintain a robust food web as a recycler of organic matter and a prey item for higher trophic level species like fish. In the present study, we investigated the ωx enzymes from the common ragworm, Hediste diversicolor, a common inhabitant in sedimentary littoral ecosystems of the North Atlantic. Functional assays of the H. diversicolor ωx demonstrated unique desaturation capacities. An ω3 desaturase mediated the conversion of n-6 fatty acid substrates into their corresponding n-3 products including DHA. A further enzyme possessed unique regioselectivities combining both ω6 and ω3 desaturase activities. These results illustrate that the long-chain PUFA biosynthetic enzymatic machinery of aquatic invertebrates such as polychaetes is highly diverse and clarify that invertebrates can be major contributors to fatty acid trophic upgrading in aquatic food webs. This article is part of the theme issue ‘The next horizons for lipids as ‘trophic biomarkers’: evidence and significance of consumer modification of dietary fatty acids’. |
format |
Text |
author |
Kabeya, Naoki Gür, İbrahim Oboh, Angela Evjemo, Jan Ove Malzahn, Arne M. Hontoria, Francisco Navarro, Juan C. Monroig, Óscar |
author_facet |
Kabeya, Naoki Gür, İbrahim Oboh, Angela Evjemo, Jan Ove Malzahn, Arne M. Hontoria, Francisco Navarro, Juan C. Monroig, Óscar |
author_sort |
Kabeya, Naoki |
title |
Unique fatty acid desaturase capacities uncovered in Hediste diversicolor illustrate the roles of aquatic invertebrates in trophic upgrading |
title_short |
Unique fatty acid desaturase capacities uncovered in Hediste diversicolor illustrate the roles of aquatic invertebrates in trophic upgrading |
title_full |
Unique fatty acid desaturase capacities uncovered in Hediste diversicolor illustrate the roles of aquatic invertebrates in trophic upgrading |
title_fullStr |
Unique fatty acid desaturase capacities uncovered in Hediste diversicolor illustrate the roles of aquatic invertebrates in trophic upgrading |
title_full_unstemmed |
Unique fatty acid desaturase capacities uncovered in Hediste diversicolor illustrate the roles of aquatic invertebrates in trophic upgrading |
title_sort |
unique fatty acid desaturase capacities uncovered in hediste diversicolor illustrate the roles of aquatic invertebrates in trophic upgrading |
publisher |
The Royal Society |
publishDate |
2020 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333967/ http://www.ncbi.nlm.nih.gov/pubmed/32536307 https://doi.org/10.1098/rstb.2019.0654 |
genre |
North Atlantic |
genre_facet |
North Atlantic |
op_source |
Philos Trans R Soc Lond B Biol Sci |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333967/ http://www.ncbi.nlm.nih.gov/pubmed/32536307 http://dx.doi.org/10.1098/rstb.2019.0654 |
op_rights |
© 2020 The Author(s) https://royalsociety.org/-/media/journals/author/Licence-to-Publish-20062019-final.pdfhttps://royalsociety.org/journals/ethics-policies/data-sharing-mining/Published by the Royal Society. All rights reserved. |
op_doi |
https://doi.org/10.1098/rstb.2019.0654 |
container_title |
Philosophical Transactions of the Royal Society B: Biological Sciences |
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375 |
container_issue |
1804 |
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20190654 |
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