Genetic factors for short life span associated with evolution of the loss of flight ability
Acquisition or loss of flying ability is evolutionarily linked with maximum life span (MLS) in mammals and birds. Although ecological factors, such as extrinsic mortality, may lead to either shortened or extended life spans through natural selection, MLS is influenced by complex molecular and metabo...
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ftpubmed:oai:pubmedcentral.nih.gov:7319159 2023-05-15T16:06:00+02:00 Genetic factors for short life span associated with evolution of the loss of flight ability Ikemoto, Atsushi Sato, Daiki X. Makino, Takashi Kawata, Masakado 2020-05-29 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319159/ http://www.ncbi.nlm.nih.gov/pubmed/32607209 https://doi.org/10.1002/ece3.6342 en eng John Wiley and Sons Inc. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319159/ http://www.ncbi.nlm.nih.gov/pubmed/32607209 http://dx.doi.org/10.1002/ece3.6342 © 2020 The Authors. Ecology and Evolution published by John Wiley & Sons Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. CC-BY Ecol Evol Original Research Text 2020 ftpubmed https://doi.org/10.1002/ece3.6342 2020-07-05T00:50:22Z Acquisition or loss of flying ability is evolutionarily linked with maximum life span (MLS) in mammals and birds. Although ecological factors, such as extrinsic mortality, may lead to either shortened or extended life spans through natural selection, MLS is influenced by complex molecular and metabolic processes, and the genetic changes associated with flying ability that have led to either a longer or shorter MLS are unknown. Here, we examine the parallel evolution of flight in mammals and birds and investigate positively selected genes at branches where either the acquisition (in little brown bats and large flying foxes) or loss (in Adélie penguins, emperor penguins, common ostriches, emus, great spotted kiwis, little spotted kiwis, okarito brown kiwis, greater rheas, lesser rheas, and cassowaries) of flight abilities occurred. Although we found no shared genes under selection among all the branches of interest, 7 genes were found to be positively selected in 2 of the branches. Among the 7 genes, only IGF2BP2 is known to affect both life span and energy expenditure. The positively selected mutations detected in IGF2BP2 likely affected the functionality of the encoded protein. IGF2BP2, which has been reported to simultaneously prolong life span and increase energy expenditure, could be responsible for the evolution of shortened MLS associated with the loss of flying ability. Text Emperor penguins PubMed Central (PMC) Ecology and Evolution 10 12 6020 6029 |
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Original Research Ikemoto, Atsushi Sato, Daiki X. Makino, Takashi Kawata, Masakado Genetic factors for short life span associated with evolution of the loss of flight ability |
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Original Research |
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Acquisition or loss of flying ability is evolutionarily linked with maximum life span (MLS) in mammals and birds. Although ecological factors, such as extrinsic mortality, may lead to either shortened or extended life spans through natural selection, MLS is influenced by complex molecular and metabolic processes, and the genetic changes associated with flying ability that have led to either a longer or shorter MLS are unknown. Here, we examine the parallel evolution of flight in mammals and birds and investigate positively selected genes at branches where either the acquisition (in little brown bats and large flying foxes) or loss (in Adélie penguins, emperor penguins, common ostriches, emus, great spotted kiwis, little spotted kiwis, okarito brown kiwis, greater rheas, lesser rheas, and cassowaries) of flight abilities occurred. Although we found no shared genes under selection among all the branches of interest, 7 genes were found to be positively selected in 2 of the branches. Among the 7 genes, only IGF2BP2 is known to affect both life span and energy expenditure. The positively selected mutations detected in IGF2BP2 likely affected the functionality of the encoded protein. IGF2BP2, which has been reported to simultaneously prolong life span and increase energy expenditure, could be responsible for the evolution of shortened MLS associated with the loss of flying ability. |
format |
Text |
author |
Ikemoto, Atsushi Sato, Daiki X. Makino, Takashi Kawata, Masakado |
author_facet |
Ikemoto, Atsushi Sato, Daiki X. Makino, Takashi Kawata, Masakado |
author_sort |
Ikemoto, Atsushi |
title |
Genetic factors for short life span associated with evolution of the loss of flight ability |
title_short |
Genetic factors for short life span associated with evolution of the loss of flight ability |
title_full |
Genetic factors for short life span associated with evolution of the loss of flight ability |
title_fullStr |
Genetic factors for short life span associated with evolution of the loss of flight ability |
title_full_unstemmed |
Genetic factors for short life span associated with evolution of the loss of flight ability |
title_sort |
genetic factors for short life span associated with evolution of the loss of flight ability |
publisher |
John Wiley and Sons Inc. |
publishDate |
2020 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319159/ http://www.ncbi.nlm.nih.gov/pubmed/32607209 https://doi.org/10.1002/ece3.6342 |
genre |
Emperor penguins |
genre_facet |
Emperor penguins |
op_source |
Ecol Evol |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319159/ http://www.ncbi.nlm.nih.gov/pubmed/32607209 http://dx.doi.org/10.1002/ece3.6342 |
op_rights |
© 2020 The Authors. Ecology and Evolution published by John Wiley & Sons Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1002/ece3.6342 |
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Ecology and Evolution |
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10 |
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12 |
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6020 |
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6029 |
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1766401914397786112 |