Early environmental factors and somatic comorbidity in schizophrenia and nonschizophrenic psychoses: A 50-year follow-up of the Northern Finland Birth Cohort 1966
BACKGROUND. We studied the cumulative incidence of physical illnesses, and the effect of early environmental factors (EEFs) on somatic comorbidity in schizophrenia, in nonschizophrenic psychosis and among nonpsychotic controls from birth up to the age of 50 years. METHODS. The sample included 10,933...
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ftpubmed:oai:pubmedcentral.nih.gov:7315879 2023-05-15T17:42:19+02:00 Early environmental factors and somatic comorbidity in schizophrenia and nonschizophrenic psychoses: A 50-year follow-up of the Northern Finland Birth Cohort 1966 Korpela, Hanna Miettunen, Jouko Rautio, Nina Isohanni, Matti Järvelin, Marjo-Riitta Jääskeläinen, Erika Auvinen, Juha Keinänen-Kiukaanniemi, Sirkka Nordström, Tanja Seppälä, Jussi 2020-02-21 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315879/ http://www.ncbi.nlm.nih.gov/pubmed/32146919 https://doi.org/10.1192/j.eurpsy.2020.25 en eng Cambridge University Press http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315879/ http://www.ncbi.nlm.nih.gov/pubmed/32146919 http://dx.doi.org/10.1192/j.eurpsy.2020.25 © The Author(s) 2020 http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited. CC-BY Eur Psychiatry Research Article Text 2020 ftpubmed https://doi.org/10.1192/j.eurpsy.2020.25 2020-07-12T00:19:40Z BACKGROUND. We studied the cumulative incidence of physical illnesses, and the effect of early environmental factors (EEFs) on somatic comorbidity in schizophrenia, in nonschizophrenic psychosis and among nonpsychotic controls from birth up to the age of 50 years. METHODS. The sample included 10,933 members of the Northern Finland Birth Cohort 1966, of whom, 227 had schizophrenia and 205 had nonschizophrenic psychosis. Diagnoses concerning physical illnesses were based on nationwide registers followed up to the end of 2016 and classified into 13 illness categories. Maternal education and age, family type at birth and paternal socioeconomic status were studied as EEFs of somatic illnesses. RESULTS. When adjusted by gender and education, individuals and especially women with nonschizophrenic psychosis had higher risk of morbidity in almost all somatic illness categories compared to controls, and in some categories, compared to individuals with schizophrenia. The statistically significant adjusted hazard ratios varied from 1.27 to 2.42 in nonschizophrenic psychosis. Regarding EEFs, single-parent family as the family type at birth was a risk factor for a higher somatic score among men with schizophrenia and women with nonschizophrenic psychosis. Maternal age over 35 years was associated with lower somatic score among women with nonschizophrenic psychosis. CONCLUSIONS. Persons with nonschizophrenic psychoses have higher incidence of somatic diseases compared to people with schizophrenia and nonpsychotic controls, and this should be noted in clinical work. EEFs have mostly weak association with somatic comorbidity in our study. Text Northern Finland PubMed Central (PMC) European Psychiatry 63 1 |
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Research Article Korpela, Hanna Miettunen, Jouko Rautio, Nina Isohanni, Matti Järvelin, Marjo-Riitta Jääskeläinen, Erika Auvinen, Juha Keinänen-Kiukaanniemi, Sirkka Nordström, Tanja Seppälä, Jussi Early environmental factors and somatic comorbidity in schizophrenia and nonschizophrenic psychoses: A 50-year follow-up of the Northern Finland Birth Cohort 1966 |
topic_facet |
Research Article |
description |
BACKGROUND. We studied the cumulative incidence of physical illnesses, and the effect of early environmental factors (EEFs) on somatic comorbidity in schizophrenia, in nonschizophrenic psychosis and among nonpsychotic controls from birth up to the age of 50 years. METHODS. The sample included 10,933 members of the Northern Finland Birth Cohort 1966, of whom, 227 had schizophrenia and 205 had nonschizophrenic psychosis. Diagnoses concerning physical illnesses were based on nationwide registers followed up to the end of 2016 and classified into 13 illness categories. Maternal education and age, family type at birth and paternal socioeconomic status were studied as EEFs of somatic illnesses. RESULTS. When adjusted by gender and education, individuals and especially women with nonschizophrenic psychosis had higher risk of morbidity in almost all somatic illness categories compared to controls, and in some categories, compared to individuals with schizophrenia. The statistically significant adjusted hazard ratios varied from 1.27 to 2.42 in nonschizophrenic psychosis. Regarding EEFs, single-parent family as the family type at birth was a risk factor for a higher somatic score among men with schizophrenia and women with nonschizophrenic psychosis. Maternal age over 35 years was associated with lower somatic score among women with nonschizophrenic psychosis. CONCLUSIONS. Persons with nonschizophrenic psychoses have higher incidence of somatic diseases compared to people with schizophrenia and nonpsychotic controls, and this should be noted in clinical work. EEFs have mostly weak association with somatic comorbidity in our study. |
format |
Text |
author |
Korpela, Hanna Miettunen, Jouko Rautio, Nina Isohanni, Matti Järvelin, Marjo-Riitta Jääskeläinen, Erika Auvinen, Juha Keinänen-Kiukaanniemi, Sirkka Nordström, Tanja Seppälä, Jussi |
author_facet |
Korpela, Hanna Miettunen, Jouko Rautio, Nina Isohanni, Matti Järvelin, Marjo-Riitta Jääskeläinen, Erika Auvinen, Juha Keinänen-Kiukaanniemi, Sirkka Nordström, Tanja Seppälä, Jussi |
author_sort |
Korpela, Hanna |
title |
Early environmental factors and somatic comorbidity in schizophrenia and nonschizophrenic psychoses: A 50-year follow-up of the Northern Finland Birth Cohort 1966 |
title_short |
Early environmental factors and somatic comorbidity in schizophrenia and nonschizophrenic psychoses: A 50-year follow-up of the Northern Finland Birth Cohort 1966 |
title_full |
Early environmental factors and somatic comorbidity in schizophrenia and nonschizophrenic psychoses: A 50-year follow-up of the Northern Finland Birth Cohort 1966 |
title_fullStr |
Early environmental factors and somatic comorbidity in schizophrenia and nonschizophrenic psychoses: A 50-year follow-up of the Northern Finland Birth Cohort 1966 |
title_full_unstemmed |
Early environmental factors and somatic comorbidity in schizophrenia and nonschizophrenic psychoses: A 50-year follow-up of the Northern Finland Birth Cohort 1966 |
title_sort |
early environmental factors and somatic comorbidity in schizophrenia and nonschizophrenic psychoses: a 50-year follow-up of the northern finland birth cohort 1966 |
publisher |
Cambridge University Press |
publishDate |
2020 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315879/ http://www.ncbi.nlm.nih.gov/pubmed/32146919 https://doi.org/10.1192/j.eurpsy.2020.25 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_source |
Eur Psychiatry |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315879/ http://www.ncbi.nlm.nih.gov/pubmed/32146919 http://dx.doi.org/10.1192/j.eurpsy.2020.25 |
op_rights |
© The Author(s) 2020 http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited. |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1192/j.eurpsy.2020.25 |
container_title |
European Psychiatry |
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63 |
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1 |
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1766144167536230400 |