Self-Reported Polycystic Ovary Syndrome Is Associated With Hypertension: A Northern Finland Birth Cohort 1966 Study
CONTEXT: Polycystic ovary syndrome (PCOS) is associated with many traditional cardiovascular disease risk factors, but it is unclear whether PCOS is an independent risk factor for hypertension. OBJECTIVE: To investigate in a population-based setup whether PCOS associates with the risk of hypertensio...
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Endocrine Society
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ftpubmed:oai:pubmedcentral.nih.gov:7296204 2023-05-15T17:42:24+02:00 Self-Reported Polycystic Ovary Syndrome Is Associated With Hypertension: A Northern Finland Birth Cohort 1966 Study Ollila, Meri-Maija E Kaikkonen, Kari Järvelin, Marjo-Riitta Huikuri, Heikki V Tapanainen, Juha S Franks, Stephen Piltonen, Terhi T Morin-Papunen, Laure 2018-11-15 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296204/ http://www.ncbi.nlm.nih.gov/pubmed/30445634 https://doi.org/10.1210/jc.2018-00570 en eng Endocrine Society http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296204/ http://www.ncbi.nlm.nih.gov/pubmed/30445634 http://dx.doi.org/10.1210/jc.2018-00570 Copyright © 2019 Endocrine Society J Clin Endocrinol Metab Clinical Research Articles Text 2018 ftpubmed https://doi.org/10.1210/jc.2018-00570 2020-06-28T00:19:09Z CONTEXT: Polycystic ovary syndrome (PCOS) is associated with many traditional cardiovascular disease risk factors, but it is unclear whether PCOS is an independent risk factor for hypertension. OBJECTIVE: To investigate in a population-based setup whether PCOS associates with the risk of hypertension independently of body mass index (BMI) and with cardiovascular manifestations. DESIGN: Cross-sectional assessments in the Northern Finland Birth Cohort 1966 at ages 31 and 46 years. SETTING: General community. PARTICIPANTS: Women who reported both oligo/amenorrhea and hirsutism at age 31 years and/or a diagnosis of PCOS by age 46 years [self-reported PCOS (srPCOS), n = 279] and women without PCOS symptoms or diagnosis (n = 1577). INTERVENTION: None. MAIN OUTCOME MEASURES: Blood pressure (BP), BMI, and cardiovascular manifestations. RESULTS: Use of antihypertensive medication was significantly more common in women with srPCOS. At age 31 years, women with srPCOS had significantly higher systolic BP (SBP) and diastolic BP (DBP) than control women (SBP: normal weight: 119.9 ± 13.2 vs 116.9 ± 11.4 mm Hg, P = 0.017; overweight/obese: 126.1 ± 14.3 vs 123.0 ± 11.9 mm Hg, P = 0.031; and DBP: normal weight: 75.5 ± 10.0 vs 72.4 ± 9.6 mm Hg, P = 0.003; overweight/obese: 80.7 ± 11.8 vs 78.0 ± 10.6 mm Hg, P = 0.031). At age 46 years, srPCOS was significantly associated with hypertension (adjusted odds ratio = 1.56; 95% CI, 1.14 to 2.13) independently of BMI and with higher cardiovascular morbidity (6.8% vs 3.4%, P = 0.011). Hypertensive srPCOS displayed consistent, unfavorable changes in cardiac structure and function compared with controls. CONCLUSION: Women with srPCOS displayed higher BP compared with controls already at early age and srPCOS was associated with hypertension independently of overweight/obesity. srPCOS was associated with increased cardiovascular morbidity in premenopausal women, suggesting that cardiovascular disease risk factors should be screened and efficiently managed early enough in women with PCOS. Text Northern Finland PubMed Central (PMC) The Journal of Clinical Endocrinology & Metabolism 104 4 1221 1231 |
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Clinical Research Articles |
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Clinical Research Articles Ollila, Meri-Maija E Kaikkonen, Kari Järvelin, Marjo-Riitta Huikuri, Heikki V Tapanainen, Juha S Franks, Stephen Piltonen, Terhi T Morin-Papunen, Laure Self-Reported Polycystic Ovary Syndrome Is Associated With Hypertension: A Northern Finland Birth Cohort 1966 Study |
topic_facet |
Clinical Research Articles |
description |
CONTEXT: Polycystic ovary syndrome (PCOS) is associated with many traditional cardiovascular disease risk factors, but it is unclear whether PCOS is an independent risk factor for hypertension. OBJECTIVE: To investigate in a population-based setup whether PCOS associates with the risk of hypertension independently of body mass index (BMI) and with cardiovascular manifestations. DESIGN: Cross-sectional assessments in the Northern Finland Birth Cohort 1966 at ages 31 and 46 years. SETTING: General community. PARTICIPANTS: Women who reported both oligo/amenorrhea and hirsutism at age 31 years and/or a diagnosis of PCOS by age 46 years [self-reported PCOS (srPCOS), n = 279] and women without PCOS symptoms or diagnosis (n = 1577). INTERVENTION: None. MAIN OUTCOME MEASURES: Blood pressure (BP), BMI, and cardiovascular manifestations. RESULTS: Use of antihypertensive medication was significantly more common in women with srPCOS. At age 31 years, women with srPCOS had significantly higher systolic BP (SBP) and diastolic BP (DBP) than control women (SBP: normal weight: 119.9 ± 13.2 vs 116.9 ± 11.4 mm Hg, P = 0.017; overweight/obese: 126.1 ± 14.3 vs 123.0 ± 11.9 mm Hg, P = 0.031; and DBP: normal weight: 75.5 ± 10.0 vs 72.4 ± 9.6 mm Hg, P = 0.003; overweight/obese: 80.7 ± 11.8 vs 78.0 ± 10.6 mm Hg, P = 0.031). At age 46 years, srPCOS was significantly associated with hypertension (adjusted odds ratio = 1.56; 95% CI, 1.14 to 2.13) independently of BMI and with higher cardiovascular morbidity (6.8% vs 3.4%, P = 0.011). Hypertensive srPCOS displayed consistent, unfavorable changes in cardiac structure and function compared with controls. CONCLUSION: Women with srPCOS displayed higher BP compared with controls already at early age and srPCOS was associated with hypertension independently of overweight/obesity. srPCOS was associated with increased cardiovascular morbidity in premenopausal women, suggesting that cardiovascular disease risk factors should be screened and efficiently managed early enough in women with PCOS. |
format |
Text |
author |
Ollila, Meri-Maija E Kaikkonen, Kari Järvelin, Marjo-Riitta Huikuri, Heikki V Tapanainen, Juha S Franks, Stephen Piltonen, Terhi T Morin-Papunen, Laure |
author_facet |
Ollila, Meri-Maija E Kaikkonen, Kari Järvelin, Marjo-Riitta Huikuri, Heikki V Tapanainen, Juha S Franks, Stephen Piltonen, Terhi T Morin-Papunen, Laure |
author_sort |
Ollila, Meri-Maija E |
title |
Self-Reported Polycystic Ovary Syndrome Is Associated With Hypertension: A Northern Finland Birth Cohort 1966 Study |
title_short |
Self-Reported Polycystic Ovary Syndrome Is Associated With Hypertension: A Northern Finland Birth Cohort 1966 Study |
title_full |
Self-Reported Polycystic Ovary Syndrome Is Associated With Hypertension: A Northern Finland Birth Cohort 1966 Study |
title_fullStr |
Self-Reported Polycystic Ovary Syndrome Is Associated With Hypertension: A Northern Finland Birth Cohort 1966 Study |
title_full_unstemmed |
Self-Reported Polycystic Ovary Syndrome Is Associated With Hypertension: A Northern Finland Birth Cohort 1966 Study |
title_sort |
self-reported polycystic ovary syndrome is associated with hypertension: a northern finland birth cohort 1966 study |
publisher |
Endocrine Society |
publishDate |
2018 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296204/ http://www.ncbi.nlm.nih.gov/pubmed/30445634 https://doi.org/10.1210/jc.2018-00570 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_source |
J Clin Endocrinol Metab |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296204/ http://www.ncbi.nlm.nih.gov/pubmed/30445634 http://dx.doi.org/10.1210/jc.2018-00570 |
op_rights |
Copyright © 2019 Endocrine Society |
op_doi |
https://doi.org/10.1210/jc.2018-00570 |
container_title |
The Journal of Clinical Endocrinology & Metabolism |
container_volume |
104 |
container_issue |
4 |
container_start_page |
1221 |
op_container_end_page |
1231 |
_version_ |
1766144263397048320 |