Real-time diagnosis of sentinel lymph nodes involved to breast cancer based on pH sensing through lipid synthesis of those cells
Lipid synthesis is the recently found metabolism of cancer cells after their metastasis to lymph nodes (LNs). Carbonic acid is the main byproduct of the lipid metabolism in such cells which resulted in acidification of LN ambient. Hence, calibrated pH sensing could be a diagnostic method to find inv...
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ftpubmed:oai:pubmedcentral.nih.gov:7280473 2023-05-15T15:52:38+02:00 Real-time diagnosis of sentinel lymph nodes involved to breast cancer based on pH sensing through lipid synthesis of those cells Miripour, Zohreh S. Aghaee, Parisa Abbasvandi, Fereshteh Hoseinpour, Parisa Parniani, Mohammad Abdolahad, Mohammad 2020-06-08 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280473/ http://www.ncbi.nlm.nih.gov/pubmed/32436938 https://doi.org/10.1042/BSR20200970 en eng Portland Press Ltd. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280473/ http://www.ncbi.nlm.nih.gov/pubmed/32436938 http://dx.doi.org/10.1042/BSR20200970 © 2020 The Author(s). https://creativecommons.org/licenses/by/4.0/ This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY). CC-BY Biosci Rep Biotechnology Text 2020 ftpubmed https://doi.org/10.1042/BSR20200970 2020-06-21T00:29:52Z Lipid synthesis is the recently found metabolism of cancer cells after their metastasis to lymph nodes (LNs). Carbonic acid is the main byproduct of the lipid metabolism in such cells which resulted in acidification of LN ambient. Hence, calibrated pH sensing could be a diagnostic method to find involved LNs. Here, we designed a simple pH sensing method by a syringe containing sterile PBS and embedded by litmus paper to intraoperatively check the pH of LN fluid. Injected phosphate buffer saline (PBS) would homogenize the LN fluid and litmus needle would detect the pH of the LN. We presented an experimental pathological calibration for the pH values in correlation with cancerous states of the LNs. This system named metabolism based metastatic lymph diagnoser (MMLD) could be a real-time noninvasive tool for precise and fast diagnosis of involved LNs. Text Carbonic acid PubMed Central (PMC) Bioscience Reports 40 6 |
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Biotechnology Miripour, Zohreh S. Aghaee, Parisa Abbasvandi, Fereshteh Hoseinpour, Parisa Parniani, Mohammad Abdolahad, Mohammad Real-time diagnosis of sentinel lymph nodes involved to breast cancer based on pH sensing through lipid synthesis of those cells |
topic_facet |
Biotechnology |
description |
Lipid synthesis is the recently found metabolism of cancer cells after their metastasis to lymph nodes (LNs). Carbonic acid is the main byproduct of the lipid metabolism in such cells which resulted in acidification of LN ambient. Hence, calibrated pH sensing could be a diagnostic method to find involved LNs. Here, we designed a simple pH sensing method by a syringe containing sterile PBS and embedded by litmus paper to intraoperatively check the pH of LN fluid. Injected phosphate buffer saline (PBS) would homogenize the LN fluid and litmus needle would detect the pH of the LN. We presented an experimental pathological calibration for the pH values in correlation with cancerous states of the LNs. This system named metabolism based metastatic lymph diagnoser (MMLD) could be a real-time noninvasive tool for precise and fast diagnosis of involved LNs. |
format |
Text |
author |
Miripour, Zohreh S. Aghaee, Parisa Abbasvandi, Fereshteh Hoseinpour, Parisa Parniani, Mohammad Abdolahad, Mohammad |
author_facet |
Miripour, Zohreh S. Aghaee, Parisa Abbasvandi, Fereshteh Hoseinpour, Parisa Parniani, Mohammad Abdolahad, Mohammad |
author_sort |
Miripour, Zohreh S. |
title |
Real-time diagnosis of sentinel lymph nodes involved to breast cancer based on pH sensing through lipid synthesis of those cells |
title_short |
Real-time diagnosis of sentinel lymph nodes involved to breast cancer based on pH sensing through lipid synthesis of those cells |
title_full |
Real-time diagnosis of sentinel lymph nodes involved to breast cancer based on pH sensing through lipid synthesis of those cells |
title_fullStr |
Real-time diagnosis of sentinel lymph nodes involved to breast cancer based on pH sensing through lipid synthesis of those cells |
title_full_unstemmed |
Real-time diagnosis of sentinel lymph nodes involved to breast cancer based on pH sensing through lipid synthesis of those cells |
title_sort |
real-time diagnosis of sentinel lymph nodes involved to breast cancer based on ph sensing through lipid synthesis of those cells |
publisher |
Portland Press Ltd. |
publishDate |
2020 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280473/ http://www.ncbi.nlm.nih.gov/pubmed/32436938 https://doi.org/10.1042/BSR20200970 |
genre |
Carbonic acid |
genre_facet |
Carbonic acid |
op_source |
Biosci Rep |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280473/ http://www.ncbi.nlm.nih.gov/pubmed/32436938 http://dx.doi.org/10.1042/BSR20200970 |
op_rights |
© 2020 The Author(s). https://creativecommons.org/licenses/by/4.0/ This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY). |
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CC-BY |
op_doi |
https://doi.org/10.1042/BSR20200970 |
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Bioscience Reports |
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40 |
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6 |
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1766387755291508736 |