Omega-3 Fatty Acid Biomarkers and Sleep: Pooled Analysis of Prospective Studies in the Fatty Acids and Outcome Research Consortium (FORCE)
OBJECTIVES: To assess associations between individual and total circulating n-3 fatty acids (FAs) with self-reported sleep duration and difficulty sleeping in the Fatty Acids and Outcome Research Consortium (FORCE). METHODS: De novo harmonized individual-level analyses were performed and pooled in 1...
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ftpubmed:oai:pubmedcentral.nih.gov:7259109 2023-05-15T16:52:42+02:00 Omega-3 Fatty Acid Biomarkers and Sleep: Pooled Analysis of Prospective Studies in the Fatty Acids and Outcome Research Consortium (FORCE) Murphy, Rachel Gu, Qianqian Marklund, Matti Riserus, Ulf Virtanen, Jyrki Tintle, Nathan Wood, Alexis Gudnason, Vilmundur Carnethon, Mercedes Harris, William de Mello, Vanessa Uusitupa, Matti Lindberg, Eva Dam, Rob Martinus Van Liu, Buyun Shadyab, Aladdin 2020-05-29 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259109/ https://doi.org/10.1093/cdn/nzaa061_088 en eng Oxford University Press http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259109/ http://dx.doi.org/10.1093/cdn/nzaa061_088 Copyright © The Author(s) on behalf of the American Society for Nutrition 2020. https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) Curr Dev Nutr Nutritional Epidemiology Text 2020 ftpubmed https://doi.org/10.1093/cdn/nzaa061_088 2020-06-07T00:48:10Z OBJECTIVES: To assess associations between individual and total circulating n-3 fatty acids (FAs) with self-reported sleep duration and difficulty sleeping in the Fatty Acids and Outcome Research Consortium (FORCE). METHODS: De novo harmonized individual-level analyses were performed and pooled in 10 prospective studies (N = 22,717) with data on sleep duration and 7 studies (N = 9997) with data on difficulty initiating sleeping (DIS). Participant ages ranged from 35 to 96 years from 5 countries (Finland, Iceland, Sweden, Singapore, and the United States). Measured circulating FAs included alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), docosahexaenoic acid (DHA), and the sum of EPA, DPA and DHA. FAs were expressed as a % of total FAs. Self-reported sleep duration was categorized as short (<7 hrs), 7–8 hrs (reference) or long (>8 hrs). DIS was categorized as yes or no (reference). Cross-sectional associations were assessed by multinomial logistic regression in each study with a standardized protocol including definitions for exposures, outcomes and covariates (demographics, health factors and dietary habits). Cohort-specific odds ratios (OR) per quintile (reference: Q1) of FAs were pooled with inverse-variance weighted meta-analysis. RESULTS: In pooled multivariate analysis, we found that participants with higher circulating n-3 FAs (Q5) had a lower risk of short and long sleep duration. For short sleep ORs (95% confidence intervals, CI) for Q5 were 0.87 (0.78–0.98) for EPA, 0.87 (0.77–0.97) for DPA, 0.83 (0.73–0.93) for DHA and 0.83 (0.74–0.93) for the sum of EPA, DPA and DHA, respectively. For long sleep ORs (95% CI) were 0.79 (0.64–0.97) for DHA, and 0.80 (0.65–0.98) for the sum of EPA, DPA and DHA. The only significant association observed for DIS was for Q3 of DHA, OR = 0.77, 95% CI = 0.63–0.96. CONCLUSIONS: In pooled de novo analyses across multiple cohorts, higher levels of n-3 FAs are associated with lower risk of suboptimal sleep (i.e., too little or too much ... Text Iceland PubMed Central (PMC) Current Developments in Nutrition 4 Supplement_2 1460 1460 |
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PubMed Central (PMC) |
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English |
topic |
Nutritional Epidemiology |
spellingShingle |
Nutritional Epidemiology Murphy, Rachel Gu, Qianqian Marklund, Matti Riserus, Ulf Virtanen, Jyrki Tintle, Nathan Wood, Alexis Gudnason, Vilmundur Carnethon, Mercedes Harris, William de Mello, Vanessa Uusitupa, Matti Lindberg, Eva Dam, Rob Martinus Van Liu, Buyun Shadyab, Aladdin Omega-3 Fatty Acid Biomarkers and Sleep: Pooled Analysis of Prospective Studies in the Fatty Acids and Outcome Research Consortium (FORCE) |
topic_facet |
Nutritional Epidemiology |
description |
OBJECTIVES: To assess associations between individual and total circulating n-3 fatty acids (FAs) with self-reported sleep duration and difficulty sleeping in the Fatty Acids and Outcome Research Consortium (FORCE). METHODS: De novo harmonized individual-level analyses were performed and pooled in 10 prospective studies (N = 22,717) with data on sleep duration and 7 studies (N = 9997) with data on difficulty initiating sleeping (DIS). Participant ages ranged from 35 to 96 years from 5 countries (Finland, Iceland, Sweden, Singapore, and the United States). Measured circulating FAs included alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), docosahexaenoic acid (DHA), and the sum of EPA, DPA and DHA. FAs were expressed as a % of total FAs. Self-reported sleep duration was categorized as short (<7 hrs), 7–8 hrs (reference) or long (>8 hrs). DIS was categorized as yes or no (reference). Cross-sectional associations were assessed by multinomial logistic regression in each study with a standardized protocol including definitions for exposures, outcomes and covariates (demographics, health factors and dietary habits). Cohort-specific odds ratios (OR) per quintile (reference: Q1) of FAs were pooled with inverse-variance weighted meta-analysis. RESULTS: In pooled multivariate analysis, we found that participants with higher circulating n-3 FAs (Q5) had a lower risk of short and long sleep duration. For short sleep ORs (95% confidence intervals, CI) for Q5 were 0.87 (0.78–0.98) for EPA, 0.87 (0.77–0.97) for DPA, 0.83 (0.73–0.93) for DHA and 0.83 (0.74–0.93) for the sum of EPA, DPA and DHA, respectively. For long sleep ORs (95% CI) were 0.79 (0.64–0.97) for DHA, and 0.80 (0.65–0.98) for the sum of EPA, DPA and DHA. The only significant association observed for DIS was for Q3 of DHA, OR = 0.77, 95% CI = 0.63–0.96. CONCLUSIONS: In pooled de novo analyses across multiple cohorts, higher levels of n-3 FAs are associated with lower risk of suboptimal sleep (i.e., too little or too much ... |
format |
Text |
author |
Murphy, Rachel Gu, Qianqian Marklund, Matti Riserus, Ulf Virtanen, Jyrki Tintle, Nathan Wood, Alexis Gudnason, Vilmundur Carnethon, Mercedes Harris, William de Mello, Vanessa Uusitupa, Matti Lindberg, Eva Dam, Rob Martinus Van Liu, Buyun Shadyab, Aladdin |
author_facet |
Murphy, Rachel Gu, Qianqian Marklund, Matti Riserus, Ulf Virtanen, Jyrki Tintle, Nathan Wood, Alexis Gudnason, Vilmundur Carnethon, Mercedes Harris, William de Mello, Vanessa Uusitupa, Matti Lindberg, Eva Dam, Rob Martinus Van Liu, Buyun Shadyab, Aladdin |
author_sort |
Murphy, Rachel |
title |
Omega-3 Fatty Acid Biomarkers and Sleep: Pooled Analysis of Prospective Studies in the Fatty Acids and Outcome Research Consortium (FORCE) |
title_short |
Omega-3 Fatty Acid Biomarkers and Sleep: Pooled Analysis of Prospective Studies in the Fatty Acids and Outcome Research Consortium (FORCE) |
title_full |
Omega-3 Fatty Acid Biomarkers and Sleep: Pooled Analysis of Prospective Studies in the Fatty Acids and Outcome Research Consortium (FORCE) |
title_fullStr |
Omega-3 Fatty Acid Biomarkers and Sleep: Pooled Analysis of Prospective Studies in the Fatty Acids and Outcome Research Consortium (FORCE) |
title_full_unstemmed |
Omega-3 Fatty Acid Biomarkers and Sleep: Pooled Analysis of Prospective Studies in the Fatty Acids and Outcome Research Consortium (FORCE) |
title_sort |
omega-3 fatty acid biomarkers and sleep: pooled analysis of prospective studies in the fatty acids and outcome research consortium (force) |
publisher |
Oxford University Press |
publishDate |
2020 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259109/ https://doi.org/10.1093/cdn/nzaa061_088 |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Curr Dev Nutr |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259109/ http://dx.doi.org/10.1093/cdn/nzaa061_088 |
op_rights |
Copyright © The Author(s) on behalf of the American Society for Nutrition 2020. https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) |
op_doi |
https://doi.org/10.1093/cdn/nzaa061_088 |
container_title |
Current Developments in Nutrition |
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4 |
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Supplement_2 |
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1460 |
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1460 |
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1766043077068193792 |