Evidence of Pathogen-Induced Immunogenetic Selection across the Large Geographic Range of a Wild Seabird
Over evolutionary time, pathogen challenge shapes the immune phenotype of the host to better respond to an incipient threat. The extent and direction of this selection pressure depend on the local pathogen composition, which is in turn determined by biotic and abiotic features of the environment. Ho...
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ftpubmed:oai:pubmedcentral.nih.gov:7253215 2023-05-15T16:19:36+02:00 Evidence of Pathogen-Induced Immunogenetic Selection across the Large Geographic Range of a Wild Seabird Levy, Hila Fiddaman, Steven R Vianna, Juliana A Noll, Daly Clucas, Gemma V Sidhu, Jasmine K H Polito, Michael J Bost, Charles A Phillips, Richard A Crofts, Sarah Miller, Gary D Pistorius, Pierre Bonnadonna, Francesco Le Bohec, Céline Barbosa, Andrés Trathan, Phil Raya Rey, Andrea Frantz, Laurent A F Hart, Tom Smith, Adrian L 2020-06 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253215/ http://www.ncbi.nlm.nih.gov/pubmed/32096861 https://doi.org/10.1093/molbev/msaa040 en eng Oxford University Press http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253215/ http://www.ncbi.nlm.nih.gov/pubmed/32096861 http://dx.doi.org/10.1093/molbev/msaa040 © The Author(s) 2020. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. CC-BY Mol Biol Evol Discoveries Text 2020 ftpubmed https://doi.org/10.1093/molbev/msaa040 2020-06-07T00:42:54Z Over evolutionary time, pathogen challenge shapes the immune phenotype of the host to better respond to an incipient threat. The extent and direction of this selection pressure depend on the local pathogen composition, which is in turn determined by biotic and abiotic features of the environment. However, little is known about adaptation to local pathogen threats in wild animals. The Gentoo penguin (Pygoscelis papua) is a species complex that lends itself to the study of immune adaptation because of its circumpolar distribution over a large latitudinal range, with little or no admixture between different clades. In this study, we examine the diversity in a key family of innate immune genes—the Toll-like receptors (TLRs)—across the range of the Gentoo penguin. The three TLRs that we investigated present varying levels of diversity, with TLR4 and TLR5 greatly exceeding the diversity of TLR7. We present evidence of positive selection in TLR4 and TLR5, which points to pathogen-driven adaptation to the local pathogen milieu. Finally, we demonstrate that two positively selected cosegregating sites in TLR5 are sufficient to alter the responsiveness of the receptor to its bacterial ligand, flagellin. Taken together, these results suggest that Gentoo penguins have experienced distinct pathogen-driven selection pressures in different environments, which may be important given the role of the Gentoo penguin as a sentinel species in some of the world’s most rapidly changing environments. Text Gentoo penguin Pygoscelis papua PubMed Central (PMC) Molecular Biology and Evolution 37 6 1708 1726 |
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Discoveries Levy, Hila Fiddaman, Steven R Vianna, Juliana A Noll, Daly Clucas, Gemma V Sidhu, Jasmine K H Polito, Michael J Bost, Charles A Phillips, Richard A Crofts, Sarah Miller, Gary D Pistorius, Pierre Bonnadonna, Francesco Le Bohec, Céline Barbosa, Andrés Trathan, Phil Raya Rey, Andrea Frantz, Laurent A F Hart, Tom Smith, Adrian L Evidence of Pathogen-Induced Immunogenetic Selection across the Large Geographic Range of a Wild Seabird |
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Discoveries |
description |
Over evolutionary time, pathogen challenge shapes the immune phenotype of the host to better respond to an incipient threat. The extent and direction of this selection pressure depend on the local pathogen composition, which is in turn determined by biotic and abiotic features of the environment. However, little is known about adaptation to local pathogen threats in wild animals. The Gentoo penguin (Pygoscelis papua) is a species complex that lends itself to the study of immune adaptation because of its circumpolar distribution over a large latitudinal range, with little or no admixture between different clades. In this study, we examine the diversity in a key family of innate immune genes—the Toll-like receptors (TLRs)—across the range of the Gentoo penguin. The three TLRs that we investigated present varying levels of diversity, with TLR4 and TLR5 greatly exceeding the diversity of TLR7. We present evidence of positive selection in TLR4 and TLR5, which points to pathogen-driven adaptation to the local pathogen milieu. Finally, we demonstrate that two positively selected cosegregating sites in TLR5 are sufficient to alter the responsiveness of the receptor to its bacterial ligand, flagellin. Taken together, these results suggest that Gentoo penguins have experienced distinct pathogen-driven selection pressures in different environments, which may be important given the role of the Gentoo penguin as a sentinel species in some of the world’s most rapidly changing environments. |
format |
Text |
author |
Levy, Hila Fiddaman, Steven R Vianna, Juliana A Noll, Daly Clucas, Gemma V Sidhu, Jasmine K H Polito, Michael J Bost, Charles A Phillips, Richard A Crofts, Sarah Miller, Gary D Pistorius, Pierre Bonnadonna, Francesco Le Bohec, Céline Barbosa, Andrés Trathan, Phil Raya Rey, Andrea Frantz, Laurent A F Hart, Tom Smith, Adrian L |
author_facet |
Levy, Hila Fiddaman, Steven R Vianna, Juliana A Noll, Daly Clucas, Gemma V Sidhu, Jasmine K H Polito, Michael J Bost, Charles A Phillips, Richard A Crofts, Sarah Miller, Gary D Pistorius, Pierre Bonnadonna, Francesco Le Bohec, Céline Barbosa, Andrés Trathan, Phil Raya Rey, Andrea Frantz, Laurent A F Hart, Tom Smith, Adrian L |
author_sort |
Levy, Hila |
title |
Evidence of Pathogen-Induced Immunogenetic Selection across the Large Geographic Range of a Wild Seabird |
title_short |
Evidence of Pathogen-Induced Immunogenetic Selection across the Large Geographic Range of a Wild Seabird |
title_full |
Evidence of Pathogen-Induced Immunogenetic Selection across the Large Geographic Range of a Wild Seabird |
title_fullStr |
Evidence of Pathogen-Induced Immunogenetic Selection across the Large Geographic Range of a Wild Seabird |
title_full_unstemmed |
Evidence of Pathogen-Induced Immunogenetic Selection across the Large Geographic Range of a Wild Seabird |
title_sort |
evidence of pathogen-induced immunogenetic selection across the large geographic range of a wild seabird |
publisher |
Oxford University Press |
publishDate |
2020 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253215/ http://www.ncbi.nlm.nih.gov/pubmed/32096861 https://doi.org/10.1093/molbev/msaa040 |
genre |
Gentoo penguin Pygoscelis papua |
genre_facet |
Gentoo penguin Pygoscelis papua |
op_source |
Mol Biol Evol |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253215/ http://www.ncbi.nlm.nih.gov/pubmed/32096861 http://dx.doi.org/10.1093/molbev/msaa040 |
op_rights |
© The Author(s) 2020. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1093/molbev/msaa040 |
container_title |
Molecular Biology and Evolution |
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37 |
container_issue |
6 |
container_start_page |
1708 |
op_container_end_page |
1726 |
_version_ |
1766006010006208512 |