Factors associated with quality of life in patients with Chagas disease: SaMi-Trop project
Chagas disease (CD) is a neglected tropical disease and its main consequence is chronic chagasic cardiomyopathy (CCC). The clinical manifestations of CD can cause functional limitation and impact on the perception of quality of life (QoL). We evaluated the QoL profile of patients with CD living in r...
Published in: | PLOS Neglected Tropical Diseases |
---|---|
Main Authors: | , , , , , , , |
Format: | Text |
Language: | English |
Published: |
Public Library of Science
2020
|
Subjects: | |
Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252596/ http://www.ncbi.nlm.nih.gov/pubmed/32459812 https://doi.org/10.1371/journal.pntd.0008144 |
id |
ftpubmed:oai:pubmedcentral.nih.gov:7252596 |
---|---|
record_format |
openpolar |
spelling |
ftpubmed:oai:pubmedcentral.nih.gov:7252596 2023-05-15T18:12:00+02:00 Factors associated with quality of life in patients with Chagas disease: SaMi-Trop project Quintino, Nayara Dornela Sabino, Ester Cerdeira da Silva, José Luiz Padilha Ribeiro, Antonio Luiz Pinho Ferreira, Ariela Mota Davi, Gabriela Lemes Oliveira, Claudia Di Lorenzo Cardoso, Clareci Silva 2020-05-27 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252596/ http://www.ncbi.nlm.nih.gov/pubmed/32459812 https://doi.org/10.1371/journal.pntd.0008144 en eng Public Library of Science http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252596/ http://www.ncbi.nlm.nih.gov/pubmed/32459812 http://dx.doi.org/10.1371/journal.pntd.0008144 © 2020 Quintino et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. CC-BY PLoS Negl Trop Dis Research Article Text 2020 ftpubmed https://doi.org/10.1371/journal.pntd.0008144 2020-06-14T00:22:42Z Chagas disease (CD) is a neglected tropical disease and its main consequence is chronic chagasic cardiomyopathy (CCC). The clinical manifestations of CD can cause functional limitation and impact on the perception of quality of life (QoL). We evaluated the QoL profile of patients with CD living in remote regions, and their association with socio-demographic, behavioral, and clinical characteristics.A cross-sectional study, using the baseline of a cohort study (SaMi-Trop) was conducted in the state of Minas Gerais, Brazil, an endemic region for CD. The cohort is composed of 1959 patients with CD. The patients were interviewed, and blood collection and electrocardiogram (ECG) were performed. The WHOQOL-BREF scale was used to assess QoL. Descriptive statistics were performed and, for the QoL scale, measures of central tendency and dispersion were calculated. Inflated beta regression models constructed using the gamlss framework were used, and fitted using R software. A significance level of 5% for all analyzes was adopted.QoL was evaluated in 625 participants. The Environment (57.66) and Social Relationships (73.17) domains presented the lowest and highest QoL score respectively. There was no statistically significant difference between QoL domains in the presence of CCC. In the multivariate analysis, the factors associated with a lower QoL were in the Physical domain age increase (OR: 0.95, CI: 0.91–0.99) and using an angiotensin converting enzyme inhibitor (OR 0.89; CI: 0.80–0.99); in the Social Relations domain a history of acute myocardial infarction (OR: 0.75; CI: 0.61–0.92); and in the Environment domain age increase (OR 0.94, CI 0.91–0.97). The factor associated with higher QoL was the use of angiotensin receptor blockers (OR: 1.15; CI 1.04–1.26).The findings of this study reinforce the importance of QoL indicators for planning care and clinical management of patients from remote regions with CD. TRIAL REGISTRATION: NCT02646943. Text sami PubMed Central (PMC) PLOS Neglected Tropical Diseases 14 5 e0008144 |
institution |
Open Polar |
collection |
PubMed Central (PMC) |
op_collection_id |
ftpubmed |
language |
English |
topic |
Research Article |
spellingShingle |
Research Article Quintino, Nayara Dornela Sabino, Ester Cerdeira da Silva, José Luiz Padilha Ribeiro, Antonio Luiz Pinho Ferreira, Ariela Mota Davi, Gabriela Lemes Oliveira, Claudia Di Lorenzo Cardoso, Clareci Silva Factors associated with quality of life in patients with Chagas disease: SaMi-Trop project |
topic_facet |
Research Article |
description |
Chagas disease (CD) is a neglected tropical disease and its main consequence is chronic chagasic cardiomyopathy (CCC). The clinical manifestations of CD can cause functional limitation and impact on the perception of quality of life (QoL). We evaluated the QoL profile of patients with CD living in remote regions, and their association with socio-demographic, behavioral, and clinical characteristics.A cross-sectional study, using the baseline of a cohort study (SaMi-Trop) was conducted in the state of Minas Gerais, Brazil, an endemic region for CD. The cohort is composed of 1959 patients with CD. The patients were interviewed, and blood collection and electrocardiogram (ECG) were performed. The WHOQOL-BREF scale was used to assess QoL. Descriptive statistics were performed and, for the QoL scale, measures of central tendency and dispersion were calculated. Inflated beta regression models constructed using the gamlss framework were used, and fitted using R software. A significance level of 5% for all analyzes was adopted.QoL was evaluated in 625 participants. The Environment (57.66) and Social Relationships (73.17) domains presented the lowest and highest QoL score respectively. There was no statistically significant difference between QoL domains in the presence of CCC. In the multivariate analysis, the factors associated with a lower QoL were in the Physical domain age increase (OR: 0.95, CI: 0.91–0.99) and using an angiotensin converting enzyme inhibitor (OR 0.89; CI: 0.80–0.99); in the Social Relations domain a history of acute myocardial infarction (OR: 0.75; CI: 0.61–0.92); and in the Environment domain age increase (OR 0.94, CI 0.91–0.97). The factor associated with higher QoL was the use of angiotensin receptor blockers (OR: 1.15; CI 1.04–1.26).The findings of this study reinforce the importance of QoL indicators for planning care and clinical management of patients from remote regions with CD. TRIAL REGISTRATION: NCT02646943. |
format |
Text |
author |
Quintino, Nayara Dornela Sabino, Ester Cerdeira da Silva, José Luiz Padilha Ribeiro, Antonio Luiz Pinho Ferreira, Ariela Mota Davi, Gabriela Lemes Oliveira, Claudia Di Lorenzo Cardoso, Clareci Silva |
author_facet |
Quintino, Nayara Dornela Sabino, Ester Cerdeira da Silva, José Luiz Padilha Ribeiro, Antonio Luiz Pinho Ferreira, Ariela Mota Davi, Gabriela Lemes Oliveira, Claudia Di Lorenzo Cardoso, Clareci Silva |
author_sort |
Quintino, Nayara Dornela |
title |
Factors associated with quality of life in patients with Chagas disease: SaMi-Trop project |
title_short |
Factors associated with quality of life in patients with Chagas disease: SaMi-Trop project |
title_full |
Factors associated with quality of life in patients with Chagas disease: SaMi-Trop project |
title_fullStr |
Factors associated with quality of life in patients with Chagas disease: SaMi-Trop project |
title_full_unstemmed |
Factors associated with quality of life in patients with Chagas disease: SaMi-Trop project |
title_sort |
factors associated with quality of life in patients with chagas disease: sami-trop project |
publisher |
Public Library of Science |
publishDate |
2020 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252596/ http://www.ncbi.nlm.nih.gov/pubmed/32459812 https://doi.org/10.1371/journal.pntd.0008144 |
genre |
sami |
genre_facet |
sami |
op_source |
PLoS Negl Trop Dis |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252596/ http://www.ncbi.nlm.nih.gov/pubmed/32459812 http://dx.doi.org/10.1371/journal.pntd.0008144 |
op_rights |
© 2020 Quintino et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1371/journal.pntd.0008144 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
14 |
container_issue |
5 |
container_start_page |
e0008144 |
_version_ |
1766184581677973504 |