Estimating Lactase Nonpersistence Distributions in the Multi-Ethnic Canadian Demographic: A Population-Based Study
OBJECTIVES: The lactase persistence/nonpersistence (LP/LNP) phenotypes follow a geographic pattern that is rooted in the gene-culture coevolution observed throughout the history of human migrations. The immense size and relatively open immigration policy have drawn migrants of diverse ethnicities to...
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ftpubmed:oai:pubmedcentral.nih.gov:7204802 2023-05-15T17:46:43+02:00 Estimating Lactase Nonpersistence Distributions in the Multi-Ethnic Canadian Demographic: A Population-Based Study Fung, Manyan Xue, Xiaoqing Szilagyi, Andrew 2020-06 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204802/ http://www.ncbi.nlm.nih.gov/pubmed/32395684 https://doi.org/10.1093/jcag/gwy068 en eng Oxford University Press http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204802/ http://www.ncbi.nlm.nih.gov/pubmed/32395684 http://dx.doi.org/10.1093/jcag/gwy068 © The Author(s) 2018. Published by Oxford University Press on behalf of the Canadian Association of Gastroenterology. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com CC-BY-NC J Can Assoc Gastroenterol Original Articles Text 2020 ftpubmed https://doi.org/10.1093/jcag/gwy068 2020-05-17T00:23:37Z OBJECTIVES: The lactase persistence/nonpersistence (LP/LNP) phenotypes follow a geographic pattern that is rooted in the gene-culture coevolution observed throughout the history of human migrations. The immense size and relatively open immigration policy have drawn migrants of diverse ethnicities to Canada. Among the multicultural demographic, two-thirds of the population are derived from the British Isles and northwestern France. A recent assessment of worldwide lactase distributions found Canada to have an LNP rate of 59% (confidence interval [CI] 44%–74%). This estimate is rather high compared with earlier reports that listed Canada as a country with a 10% LNP rate; the authors had also noted that biases were likely because their calculations were based largely on Aboriginal studies. We hereby present an alternate LNP prevalence estimate at the national, provincial and territorial level. METHODS: We applied the referenced LNP frequency distribution data to the 2016 population census to account for the current multi-ethnic distributions in Canada. Prevalence rates for Canada, the provinces and territories were calculated. RESULTS: The national LNP rate is estimated at 44% (CI 41%–47%) after accounting for the 254 ethnic groups, with the lowest rates found in the eastern provinces and the highest rates in the Northwest Territories (57%) and Nunavut (66%), respectively. CONCLUSION: Despite the heterogeneous nature of the referenced data and the inference measures taken, evidently, the validity of our LNP estimate is anchored on the inclusion of multi-ethnic groups representing the current Canadian demographic. Text Northwest Territories Nunavut PubMed Central (PMC) Canada Northwest Territories Nunavut Journal of the Canadian Association of Gastroenterology 3 3 103 110 |
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Original Articles |
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Original Articles Fung, Manyan Xue, Xiaoqing Szilagyi, Andrew Estimating Lactase Nonpersistence Distributions in the Multi-Ethnic Canadian Demographic: A Population-Based Study |
topic_facet |
Original Articles |
description |
OBJECTIVES: The lactase persistence/nonpersistence (LP/LNP) phenotypes follow a geographic pattern that is rooted in the gene-culture coevolution observed throughout the history of human migrations. The immense size and relatively open immigration policy have drawn migrants of diverse ethnicities to Canada. Among the multicultural demographic, two-thirds of the population are derived from the British Isles and northwestern France. A recent assessment of worldwide lactase distributions found Canada to have an LNP rate of 59% (confidence interval [CI] 44%–74%). This estimate is rather high compared with earlier reports that listed Canada as a country with a 10% LNP rate; the authors had also noted that biases were likely because their calculations were based largely on Aboriginal studies. We hereby present an alternate LNP prevalence estimate at the national, provincial and territorial level. METHODS: We applied the referenced LNP frequency distribution data to the 2016 population census to account for the current multi-ethnic distributions in Canada. Prevalence rates for Canada, the provinces and territories were calculated. RESULTS: The national LNP rate is estimated at 44% (CI 41%–47%) after accounting for the 254 ethnic groups, with the lowest rates found in the eastern provinces and the highest rates in the Northwest Territories (57%) and Nunavut (66%), respectively. CONCLUSION: Despite the heterogeneous nature of the referenced data and the inference measures taken, evidently, the validity of our LNP estimate is anchored on the inclusion of multi-ethnic groups representing the current Canadian demographic. |
format |
Text |
author |
Fung, Manyan Xue, Xiaoqing Szilagyi, Andrew |
author_facet |
Fung, Manyan Xue, Xiaoqing Szilagyi, Andrew |
author_sort |
Fung, Manyan |
title |
Estimating Lactase Nonpersistence Distributions in the Multi-Ethnic Canadian Demographic: A Population-Based Study |
title_short |
Estimating Lactase Nonpersistence Distributions in the Multi-Ethnic Canadian Demographic: A Population-Based Study |
title_full |
Estimating Lactase Nonpersistence Distributions in the Multi-Ethnic Canadian Demographic: A Population-Based Study |
title_fullStr |
Estimating Lactase Nonpersistence Distributions in the Multi-Ethnic Canadian Demographic: A Population-Based Study |
title_full_unstemmed |
Estimating Lactase Nonpersistence Distributions in the Multi-Ethnic Canadian Demographic: A Population-Based Study |
title_sort |
estimating lactase nonpersistence distributions in the multi-ethnic canadian demographic: a population-based study |
publisher |
Oxford University Press |
publishDate |
2020 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204802/ http://www.ncbi.nlm.nih.gov/pubmed/32395684 https://doi.org/10.1093/jcag/gwy068 |
geographic |
Canada Northwest Territories Nunavut |
geographic_facet |
Canada Northwest Territories Nunavut |
genre |
Northwest Territories Nunavut |
genre_facet |
Northwest Territories Nunavut |
op_source |
J Can Assoc Gastroenterol |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204802/ http://www.ncbi.nlm.nih.gov/pubmed/32395684 http://dx.doi.org/10.1093/jcag/gwy068 |
op_rights |
© The Author(s) 2018. Published by Oxford University Press on behalf of the Canadian Association of Gastroenterology. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
op_rightsnorm |
CC-BY-NC |
op_doi |
https://doi.org/10.1093/jcag/gwy068 |
container_title |
Journal of the Canadian Association of Gastroenterology |
container_volume |
3 |
container_issue |
3 |
container_start_page |
103 |
op_container_end_page |
110 |
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1766150538763698176 |