Diagnosis and Management of Carpal Tunnel Syndrome in Children with Mucopolysaccharidosis: A 10 Year Experience
Introduction: Mucopolysaccharidoses (MPS) are rare and clinically heterogeneous lysosomal storage disorders. Carpal tunnel syndrome (CTS) is a frequent complication in MPS types I, II, VI, and VII. CTS symptoms are difficult to recognize in these children, and often there is a lack of appropriate in...
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ftpubmed:oai:pubmedcentral.nih.gov:7169406 2023-05-15T16:01:49+02:00 Diagnosis and Management of Carpal Tunnel Syndrome in Children with Mucopolysaccharidosis: A 10 Year Experience Dabaj, Ivana Gitiaux, Cyril Avila-Smirnow, Daniela Ropers, Jacques Desguerre, Isabelle Salon, Arielle Pannier, Stéphanie Tebani, Abdellah Valayannopoulos, Vassili Quijano-Roy, Susana 2019-12-20 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169406/ http://www.ncbi.nlm.nih.gov/pubmed/31861915 https://doi.org/10.3390/diagnostics10010005 en eng MDPI http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169406/ http://www.ncbi.nlm.nih.gov/pubmed/31861915 http://dx.doi.org/10.3390/diagnostics10010005 © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). CC-BY Article Text 2019 ftpubmed https://doi.org/10.3390/diagnostics10010005 2020-04-26T00:42:24Z Introduction: Mucopolysaccharidoses (MPS) are rare and clinically heterogeneous lysosomal storage disorders. Carpal tunnel syndrome (CTS) is a frequent complication in MPS types I, II, VI, and VII. CTS symptoms are difficult to recognize in these children, and often there is a lack of appropriate investigations. Patients and methods: In this retrospective study, all MPS patients were referred to the electrodiagnostic (EDX) laboratory of a single academic center during a 10-year period. Forty-eight children underwent serial EDX studies for CTS diagnosis and follow-up after surgery. Forty-two patients were diagnosed with CTS. Sensory nerve conduction velocity (SNCV), distal motor latency (DML), and motor nerve conduction velocity through the wrist (MNCV-W) of the median nerve were reviewed and analyzed. Results: One-hundred-three EDX examinations were performed on 48 patients. The median age at disease diagnosis was 2.1 years versus 4.9 years for CTS diagnosis. Analysis of the series revealed that electrophysiological abnormalities of CTS could have started much earlier (before the age of 2 years or at diagnosis of MPS). Diagnosis was based on SNCV and DML results, and MNCV-W was taken into consideration. Bilateral CTS was frequent (88%) in the types of MPS studied in our population and was observed from the first year of life, and may not have be associated with obvious clinical symptoms. EDX studies also helped in the follow-up and detection of CTS relapses, thus leading to an early intervention allowing a better recovery. Conclusion: EDX studies should be performed promptly and regularly in these patients. Prospective studies are required in order to understand the effect of disease-specific therapies in preventing the development of CTS in these patients. Synopsis: EDX studies should be performed in MPS patients soon after diagnosis and during routine follow-up, before and after surgical decompression. Text DML PubMed Central (PMC) Diagnostics 10 1 5 |
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Article Dabaj, Ivana Gitiaux, Cyril Avila-Smirnow, Daniela Ropers, Jacques Desguerre, Isabelle Salon, Arielle Pannier, Stéphanie Tebani, Abdellah Valayannopoulos, Vassili Quijano-Roy, Susana Diagnosis and Management of Carpal Tunnel Syndrome in Children with Mucopolysaccharidosis: A 10 Year Experience |
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Introduction: Mucopolysaccharidoses (MPS) are rare and clinically heterogeneous lysosomal storage disorders. Carpal tunnel syndrome (CTS) is a frequent complication in MPS types I, II, VI, and VII. CTS symptoms are difficult to recognize in these children, and often there is a lack of appropriate investigations. Patients and methods: In this retrospective study, all MPS patients were referred to the electrodiagnostic (EDX) laboratory of a single academic center during a 10-year period. Forty-eight children underwent serial EDX studies for CTS diagnosis and follow-up after surgery. Forty-two patients were diagnosed with CTS. Sensory nerve conduction velocity (SNCV), distal motor latency (DML), and motor nerve conduction velocity through the wrist (MNCV-W) of the median nerve were reviewed and analyzed. Results: One-hundred-three EDX examinations were performed on 48 patients. The median age at disease diagnosis was 2.1 years versus 4.9 years for CTS diagnosis. Analysis of the series revealed that electrophysiological abnormalities of CTS could have started much earlier (before the age of 2 years or at diagnosis of MPS). Diagnosis was based on SNCV and DML results, and MNCV-W was taken into consideration. Bilateral CTS was frequent (88%) in the types of MPS studied in our population and was observed from the first year of life, and may not have be associated with obvious clinical symptoms. EDX studies also helped in the follow-up and detection of CTS relapses, thus leading to an early intervention allowing a better recovery. Conclusion: EDX studies should be performed promptly and regularly in these patients. Prospective studies are required in order to understand the effect of disease-specific therapies in preventing the development of CTS in these patients. Synopsis: EDX studies should be performed in MPS patients soon after diagnosis and during routine follow-up, before and after surgical decompression. |
format |
Text |
author |
Dabaj, Ivana Gitiaux, Cyril Avila-Smirnow, Daniela Ropers, Jacques Desguerre, Isabelle Salon, Arielle Pannier, Stéphanie Tebani, Abdellah Valayannopoulos, Vassili Quijano-Roy, Susana |
author_facet |
Dabaj, Ivana Gitiaux, Cyril Avila-Smirnow, Daniela Ropers, Jacques Desguerre, Isabelle Salon, Arielle Pannier, Stéphanie Tebani, Abdellah Valayannopoulos, Vassili Quijano-Roy, Susana |
author_sort |
Dabaj, Ivana |
title |
Diagnosis and Management of Carpal Tunnel Syndrome in Children with Mucopolysaccharidosis: A 10 Year Experience |
title_short |
Diagnosis and Management of Carpal Tunnel Syndrome in Children with Mucopolysaccharidosis: A 10 Year Experience |
title_full |
Diagnosis and Management of Carpal Tunnel Syndrome in Children with Mucopolysaccharidosis: A 10 Year Experience |
title_fullStr |
Diagnosis and Management of Carpal Tunnel Syndrome in Children with Mucopolysaccharidosis: A 10 Year Experience |
title_full_unstemmed |
Diagnosis and Management of Carpal Tunnel Syndrome in Children with Mucopolysaccharidosis: A 10 Year Experience |
title_sort |
diagnosis and management of carpal tunnel syndrome in children with mucopolysaccharidosis: a 10 year experience |
publisher |
MDPI |
publishDate |
2019 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169406/ http://www.ncbi.nlm.nih.gov/pubmed/31861915 https://doi.org/10.3390/diagnostics10010005 |
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DML |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169406/ http://www.ncbi.nlm.nih.gov/pubmed/31861915 http://dx.doi.org/10.3390/diagnostics10010005 |
op_rights |
© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
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CC-BY |
op_doi |
https://doi.org/10.3390/diagnostics10010005 |
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Diagnostics |
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