Evolutionary Basis of High-Frequency Hearing in the Cochleae of Echolocators Revealed by Comparative Genomics
High-frequency hearing is important for the survival of both echolocating bats and whales, but our understanding of its genetic basis is scattered and segmented. In this study, we combined RNA-Seq and comparative genomic analyses to obtain insights into the comprehensive gene expression profile of t...
Published in: | Genome Biology and Evolution |
---|---|
Main Authors: | , , , , , |
Format: | Text |
Language: | English |
Published: |
Oxford University Press
2019
|
Subjects: | |
Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145703/ http://www.ncbi.nlm.nih.gov/pubmed/31730196 https://doi.org/10.1093/gbe/evz250 |
id |
ftpubmed:oai:pubmedcentral.nih.gov:7145703 |
---|---|
record_format |
openpolar |
spelling |
ftpubmed:oai:pubmedcentral.nih.gov:7145703 2023-05-15T18:33:28+02:00 Evolutionary Basis of High-Frequency Hearing in the Cochleae of Echolocators Revealed by Comparative Genomics Wang, Hui Zhao, Hanbo Sun, Keping Huang, Xiaobin Jin, Longru Feng, Jiang 2019-11-15 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145703/ http://www.ncbi.nlm.nih.gov/pubmed/31730196 https://doi.org/10.1093/gbe/evz250 en eng Oxford University Press http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145703/ http://www.ncbi.nlm.nih.gov/pubmed/31730196 http://dx.doi.org/10.1093/gbe/evz250 © The Author(s) 2019. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. CC-BY Research Article Text 2019 ftpubmed https://doi.org/10.1093/gbe/evz250 2020-04-19T00:31:22Z High-frequency hearing is important for the survival of both echolocating bats and whales, but our understanding of its genetic basis is scattered and segmented. In this study, we combined RNA-Seq and comparative genomic analyses to obtain insights into the comprehensive gene expression profile of the cochlea and the adaptive evolution of hearing-related genes. A total of 144 genes were found to have been under positive selection in various species of echolocating bats and toothed whales, 34 of which were identified to be related to hearing behavior or auditory processes. Subsequently, multiple physiological processes associated with those genes were found to have adaptively evolved in echolocating bats and toothed whales, including cochlear bony development, antioxidant activity, ion balance, and homeostatic processes, along with signal transduction. In addition, abundant convergent/parallel genes and sites were detected between different pairs of echolocator species; however, no specific hearing-related physiological pathways were enriched by them and almost all of the convergent/parallel signals were selectively neutral, as previously reported. Notably, two adaptive parallel evolved sites in TECPR2 were shown to have been under positive selection, indicating their functional importance for the evolution of echolocation and high-frequency hearing in laryngeal echolocating bats. This study deepens our understanding of the genetic bases underlying high-frequency hearing in the cochlea of echolocating bats and toothed whales. Text toothed whales PubMed Central (PMC) Genome Biology and Evolution |
institution |
Open Polar |
collection |
PubMed Central (PMC) |
op_collection_id |
ftpubmed |
language |
English |
topic |
Research Article |
spellingShingle |
Research Article Wang, Hui Zhao, Hanbo Sun, Keping Huang, Xiaobin Jin, Longru Feng, Jiang Evolutionary Basis of High-Frequency Hearing in the Cochleae of Echolocators Revealed by Comparative Genomics |
topic_facet |
Research Article |
description |
High-frequency hearing is important for the survival of both echolocating bats and whales, but our understanding of its genetic basis is scattered and segmented. In this study, we combined RNA-Seq and comparative genomic analyses to obtain insights into the comprehensive gene expression profile of the cochlea and the adaptive evolution of hearing-related genes. A total of 144 genes were found to have been under positive selection in various species of echolocating bats and toothed whales, 34 of which were identified to be related to hearing behavior or auditory processes. Subsequently, multiple physiological processes associated with those genes were found to have adaptively evolved in echolocating bats and toothed whales, including cochlear bony development, antioxidant activity, ion balance, and homeostatic processes, along with signal transduction. In addition, abundant convergent/parallel genes and sites were detected between different pairs of echolocator species; however, no specific hearing-related physiological pathways were enriched by them and almost all of the convergent/parallel signals were selectively neutral, as previously reported. Notably, two adaptive parallel evolved sites in TECPR2 were shown to have been under positive selection, indicating their functional importance for the evolution of echolocation and high-frequency hearing in laryngeal echolocating bats. This study deepens our understanding of the genetic bases underlying high-frequency hearing in the cochlea of echolocating bats and toothed whales. |
format |
Text |
author |
Wang, Hui Zhao, Hanbo Sun, Keping Huang, Xiaobin Jin, Longru Feng, Jiang |
author_facet |
Wang, Hui Zhao, Hanbo Sun, Keping Huang, Xiaobin Jin, Longru Feng, Jiang |
author_sort |
Wang, Hui |
title |
Evolutionary Basis of High-Frequency Hearing in the Cochleae of Echolocators Revealed by Comparative Genomics |
title_short |
Evolutionary Basis of High-Frequency Hearing in the Cochleae of Echolocators Revealed by Comparative Genomics |
title_full |
Evolutionary Basis of High-Frequency Hearing in the Cochleae of Echolocators Revealed by Comparative Genomics |
title_fullStr |
Evolutionary Basis of High-Frequency Hearing in the Cochleae of Echolocators Revealed by Comparative Genomics |
title_full_unstemmed |
Evolutionary Basis of High-Frequency Hearing in the Cochleae of Echolocators Revealed by Comparative Genomics |
title_sort |
evolutionary basis of high-frequency hearing in the cochleae of echolocators revealed by comparative genomics |
publisher |
Oxford University Press |
publishDate |
2019 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145703/ http://www.ncbi.nlm.nih.gov/pubmed/31730196 https://doi.org/10.1093/gbe/evz250 |
genre |
toothed whales |
genre_facet |
toothed whales |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145703/ http://www.ncbi.nlm.nih.gov/pubmed/31730196 http://dx.doi.org/10.1093/gbe/evz250 |
op_rights |
© The Author(s) 2019. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1093/gbe/evz250 |
container_title |
Genome Biology and Evolution |
_version_ |
1766218082045394944 |