The temperature and pH repertoire of the transglutaminase family is expanding
Transglutaminases (TGs) play important roles in the food industry, pharmacology, and biotechnology, but as protein cross‐linkers, their complexes are stable, resistant, immunogenic, and potentially pathogenic. Many TGs have been characterized, but they operate in narrow temperature and pH range limi...
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ftpubmed:oai:pubmedcentral.nih.gov:7137796 2023-05-15T15:27:24+02:00 The temperature and pH repertoire of the transglutaminase family is expanding Lerner, Aaron Ramesh, Ajay Matthias, Torsten 2020-04-07 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7137796/ http://www.ncbi.nlm.nih.gov/pubmed/32170837 https://doi.org/10.1002/2211-5463.12839 en eng John Wiley and Sons Inc. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7137796/ http://www.ncbi.nlm.nih.gov/pubmed/32170837 http://dx.doi.org/10.1002/2211-5463.12839 © 2020 The Authors. Published by FEBS Press and John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. CC-BY Commentary Text 2020 ftpubmed https://doi.org/10.1002/2211-5463.12839 2020-04-12T01:02:37Z Transglutaminases (TGs) play important roles in the food industry, pharmacology, and biotechnology, but as protein cross‐linkers, their complexes are stable, resistant, immunogenic, and potentially pathogenic. Many TGs have been characterized, but they operate in narrow temperature and pH range limits. In a research article in this issue, Clemens Furnes and colleagues describe a novel cold‐adapted TG from Atlantic cod, which expands the operating boundaries to a lower temperature and a wider pH. In this accompanying commentary, we discuss how this TG opens new applications in cold environments and can be deactivated by heating. New sources of TGs should be explored in hot environments like hot springs, in order to increase the temperature and widen the pH ranges for human and industrial benefits. Text atlantic cod PubMed Central (PMC) Furnes ENVELOPE(15.674,15.674,67.214,67.214) FEBS Open Bio 10 4 492 494 |
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Commentary Lerner, Aaron Ramesh, Ajay Matthias, Torsten The temperature and pH repertoire of the transglutaminase family is expanding |
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Commentary |
description |
Transglutaminases (TGs) play important roles in the food industry, pharmacology, and biotechnology, but as protein cross‐linkers, their complexes are stable, resistant, immunogenic, and potentially pathogenic. Many TGs have been characterized, but they operate in narrow temperature and pH range limits. In a research article in this issue, Clemens Furnes and colleagues describe a novel cold‐adapted TG from Atlantic cod, which expands the operating boundaries to a lower temperature and a wider pH. In this accompanying commentary, we discuss how this TG opens new applications in cold environments and can be deactivated by heating. New sources of TGs should be explored in hot environments like hot springs, in order to increase the temperature and widen the pH ranges for human and industrial benefits. |
format |
Text |
author |
Lerner, Aaron Ramesh, Ajay Matthias, Torsten |
author_facet |
Lerner, Aaron Ramesh, Ajay Matthias, Torsten |
author_sort |
Lerner, Aaron |
title |
The temperature and pH repertoire of the transglutaminase family is expanding |
title_short |
The temperature and pH repertoire of the transglutaminase family is expanding |
title_full |
The temperature and pH repertoire of the transglutaminase family is expanding |
title_fullStr |
The temperature and pH repertoire of the transglutaminase family is expanding |
title_full_unstemmed |
The temperature and pH repertoire of the transglutaminase family is expanding |
title_sort |
temperature and ph repertoire of the transglutaminase family is expanding |
publisher |
John Wiley and Sons Inc. |
publishDate |
2020 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7137796/ http://www.ncbi.nlm.nih.gov/pubmed/32170837 https://doi.org/10.1002/2211-5463.12839 |
long_lat |
ENVELOPE(15.674,15.674,67.214,67.214) |
geographic |
Furnes |
geographic_facet |
Furnes |
genre |
atlantic cod |
genre_facet |
atlantic cod |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7137796/ http://www.ncbi.nlm.nih.gov/pubmed/32170837 http://dx.doi.org/10.1002/2211-5463.12839 |
op_rights |
© 2020 The Authors. Published by FEBS Press and John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
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CC-BY |
op_doi |
https://doi.org/10.1002/2211-5463.12839 |
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FEBS Open Bio |
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10 |
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4 |
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492 |
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494 |
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