Full genome characterization of two novel Alpha-coronavirus species from Italian bats
Coronaviruses (CoVs) have been detected worldwide in several bat species, which are considered the main reservoir. The attention to the high diversity of CoVs hosted by bats has increased during the last decade due to the high number of human infections caused by two zoonotic Beta-CoVs, SARS-CoV and...
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ftpubmed:oai:pubmedcentral.nih.gov:7114869 2023-05-15T17:59:55+02:00 Full genome characterization of two novel Alpha-coronavirus species from Italian bats De Sabato, Luca Lelli, Davide Faccin, Francesca Canziani, Sabrina Di Bartolo, Ilaria Vaccari, Gabriele Moreno, Ana 2019-01-15 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114869/ http://www.ncbi.nlm.nih.gov/pubmed/30447246 https://doi.org/10.1016/j.virusres.2018.11.007 en eng Elsevier B.V. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114869/ http://www.ncbi.nlm.nih.gov/pubmed/30447246 http://dx.doi.org/10.1016/j.virusres.2018.11.007 © 2018 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. Article Text 2019 ftpubmed https://doi.org/10.1016/j.virusres.2018.11.007 2020-04-05T01:01:47Z Coronaviruses (CoVs) have been detected worldwide in several bat species, which are considered the main reservoir. The attention to the high diversity of CoVs hosted by bats has increased during the last decade due to the high number of human infections caused by two zoonotic Beta-CoVs, SARS-CoV and MERS-CoV, that cause several respiratory diseases. Among coronaviruses, two Alpha-CoV strains (HuCoV-229E and HuCoV-NL63) cause mild respiratory disease that can change to severe disease in children, elderly and individuals affected by illnesses. Phylogenetic analysis conducted on bat Alpha-CoV strains revealed their evolutive correlation to human strains, suggesting their origin in bats. The genome of CoVs is characterized by a high frequency of mutations and recombination events, increasing their ability to switch hosts and their zoonotic potential. In this study, three strains of Alpha-CoV genera detected in Italian bats (Pipistrellus kuhlii) were fully sequenced by Next Generation Sequencing (NGS) and characterized. The complete genome analysis showed the correlation of the Italians strains with a Chinese strain detected in 2013 and, based on CoV molecular species demarcation, two new Alpha-CoV species were established. The analysis of a fragment of the RNA-dependent RNA polymerase (RdRp) showed the correlation of the Italian strains with CoVs that was only detected in the bat Pipistrellus genera (Pipistrellus kuhlii and Pipistrellus Pipistrellus) in European countries. Text Pipistrellus pipistrellus PubMed Central (PMC) Virus Research 260 60 66 |
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Article De Sabato, Luca Lelli, Davide Faccin, Francesca Canziani, Sabrina Di Bartolo, Ilaria Vaccari, Gabriele Moreno, Ana Full genome characterization of two novel Alpha-coronavirus species from Italian bats |
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Article |
description |
Coronaviruses (CoVs) have been detected worldwide in several bat species, which are considered the main reservoir. The attention to the high diversity of CoVs hosted by bats has increased during the last decade due to the high number of human infections caused by two zoonotic Beta-CoVs, SARS-CoV and MERS-CoV, that cause several respiratory diseases. Among coronaviruses, two Alpha-CoV strains (HuCoV-229E and HuCoV-NL63) cause mild respiratory disease that can change to severe disease in children, elderly and individuals affected by illnesses. Phylogenetic analysis conducted on bat Alpha-CoV strains revealed their evolutive correlation to human strains, suggesting their origin in bats. The genome of CoVs is characterized by a high frequency of mutations and recombination events, increasing their ability to switch hosts and their zoonotic potential. In this study, three strains of Alpha-CoV genera detected in Italian bats (Pipistrellus kuhlii) were fully sequenced by Next Generation Sequencing (NGS) and characterized. The complete genome analysis showed the correlation of the Italians strains with a Chinese strain detected in 2013 and, based on CoV molecular species demarcation, two new Alpha-CoV species were established. The analysis of a fragment of the RNA-dependent RNA polymerase (RdRp) showed the correlation of the Italian strains with CoVs that was only detected in the bat Pipistrellus genera (Pipistrellus kuhlii and Pipistrellus Pipistrellus) in European countries. |
format |
Text |
author |
De Sabato, Luca Lelli, Davide Faccin, Francesca Canziani, Sabrina Di Bartolo, Ilaria Vaccari, Gabriele Moreno, Ana |
author_facet |
De Sabato, Luca Lelli, Davide Faccin, Francesca Canziani, Sabrina Di Bartolo, Ilaria Vaccari, Gabriele Moreno, Ana |
author_sort |
De Sabato, Luca |
title |
Full genome characterization of two novel Alpha-coronavirus species from Italian bats |
title_short |
Full genome characterization of two novel Alpha-coronavirus species from Italian bats |
title_full |
Full genome characterization of two novel Alpha-coronavirus species from Italian bats |
title_fullStr |
Full genome characterization of two novel Alpha-coronavirus species from Italian bats |
title_full_unstemmed |
Full genome characterization of two novel Alpha-coronavirus species from Italian bats |
title_sort |
full genome characterization of two novel alpha-coronavirus species from italian bats |
publisher |
Elsevier B.V. |
publishDate |
2019 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114869/ http://www.ncbi.nlm.nih.gov/pubmed/30447246 https://doi.org/10.1016/j.virusres.2018.11.007 |
genre |
Pipistrellus pipistrellus |
genre_facet |
Pipistrellus pipistrellus |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114869/ http://www.ncbi.nlm.nih.gov/pubmed/30447246 http://dx.doi.org/10.1016/j.virusres.2018.11.007 |
op_rights |
© 2018 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
op_doi |
https://doi.org/10.1016/j.virusres.2018.11.007 |
container_title |
Virus Research |
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260 |
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60 |
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66 |
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1766168805948522496 |