First evidence of anticancer and antimicrobial activity in Mediterranean mesopelagic species
Mesopelagic organisms form huge biomass aggregations, supporting important pelagic trophic webs and several top predators. Although some studies on the occurrence, biology and ecology of these organisms are available, to date there are no investigations on their potential use for anticancer and anti...
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ftpubmed:oai:pubmedcentral.nih.gov:7080843 2023-05-15T17:10:42+02:00 First evidence of anticancer and antimicrobial activity in Mediterranean mesopelagic species Lauritano, Chiara Martínez, Kevin A. Battaglia, Pietro Granata, Antonia de la Cruz, Mercedes Cautain, Bastien Martín, Jesús Reyes, Fernando Ianora, Adrianna Guglielmo, Letterio 2020-03-18 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080843/ http://www.ncbi.nlm.nih.gov/pubmed/32188923 https://doi.org/10.1038/s41598-020-61515-z en eng Nature Publishing Group UK http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080843/ http://www.ncbi.nlm.nih.gov/pubmed/32188923 http://dx.doi.org/10.1038/s41598-020-61515-z © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. CC-BY Article Text 2020 ftpubmed https://doi.org/10.1038/s41598-020-61515-z 2020-03-29T01:31:48Z Mesopelagic organisms form huge biomass aggregations, supporting important pelagic trophic webs and several top predators. Although some studies on the occurrence, biology and ecology of these organisms are available, to date there are no investigations on their potential use for anticancer and antimicrobial biotechnological applications. The aim of this study was to screen extracts of seven mesopelagic species for possible anticancer (Lung cell line A549, skin cell line A2058, liver cell line HepG2, breast cell line MCF7 and pancreas cell line MiaPaca-2) and antibacterial (Gram-negative bacteria Escherichia coli and Klebsiella pneumoniae, the Gram-positive bacteria methicillin resistant/sensitive Staphylococcus aureus, and Mycobacterium tuberculosis) activities. Results showed that only two species were active, the lanternfish Myctophum punctatum and the Mediterranean krill Meganyctiphanes norvegica. In particular, M. punctatum showed strong activity against the A549 and MCF7 cells, while M. norvegica was more active against HepG2 cells. Regarding antibacterial assays, both species were active against methicillin resistant S. aureus. Fractionation and LC/MS dereplication of the fractions showed that the main compounds found in extracts of both species were EPA, DHA and ETA. For some of the detected compounds anticancer and/or antibacterial activity are already known, but this is the first time that such activities have been found for mesopelagic species. Text Meganyctiphanes norvegica PubMed Central (PMC) Eta ENVELOPE(-62.917,-62.917,-64.300,-64.300) Scientific Reports 10 1 |
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Article Lauritano, Chiara Martínez, Kevin A. Battaglia, Pietro Granata, Antonia de la Cruz, Mercedes Cautain, Bastien Martín, Jesús Reyes, Fernando Ianora, Adrianna Guglielmo, Letterio First evidence of anticancer and antimicrobial activity in Mediterranean mesopelagic species |
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Mesopelagic organisms form huge biomass aggregations, supporting important pelagic trophic webs and several top predators. Although some studies on the occurrence, biology and ecology of these organisms are available, to date there are no investigations on their potential use for anticancer and antimicrobial biotechnological applications. The aim of this study was to screen extracts of seven mesopelagic species for possible anticancer (Lung cell line A549, skin cell line A2058, liver cell line HepG2, breast cell line MCF7 and pancreas cell line MiaPaca-2) and antibacterial (Gram-negative bacteria Escherichia coli and Klebsiella pneumoniae, the Gram-positive bacteria methicillin resistant/sensitive Staphylococcus aureus, and Mycobacterium tuberculosis) activities. Results showed that only two species were active, the lanternfish Myctophum punctatum and the Mediterranean krill Meganyctiphanes norvegica. In particular, M. punctatum showed strong activity against the A549 and MCF7 cells, while M. norvegica was more active against HepG2 cells. Regarding antibacterial assays, both species were active against methicillin resistant S. aureus. Fractionation and LC/MS dereplication of the fractions showed that the main compounds found in extracts of both species were EPA, DHA and ETA. For some of the detected compounds anticancer and/or antibacterial activity are already known, but this is the first time that such activities have been found for mesopelagic species. |
format |
Text |
author |
Lauritano, Chiara Martínez, Kevin A. Battaglia, Pietro Granata, Antonia de la Cruz, Mercedes Cautain, Bastien Martín, Jesús Reyes, Fernando Ianora, Adrianna Guglielmo, Letterio |
author_facet |
Lauritano, Chiara Martínez, Kevin A. Battaglia, Pietro Granata, Antonia de la Cruz, Mercedes Cautain, Bastien Martín, Jesús Reyes, Fernando Ianora, Adrianna Guglielmo, Letterio |
author_sort |
Lauritano, Chiara |
title |
First evidence of anticancer and antimicrobial activity in Mediterranean mesopelagic species |
title_short |
First evidence of anticancer and antimicrobial activity in Mediterranean mesopelagic species |
title_full |
First evidence of anticancer and antimicrobial activity in Mediterranean mesopelagic species |
title_fullStr |
First evidence of anticancer and antimicrobial activity in Mediterranean mesopelagic species |
title_full_unstemmed |
First evidence of anticancer and antimicrobial activity in Mediterranean mesopelagic species |
title_sort |
first evidence of anticancer and antimicrobial activity in mediterranean mesopelagic species |
publisher |
Nature Publishing Group UK |
publishDate |
2020 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080843/ http://www.ncbi.nlm.nih.gov/pubmed/32188923 https://doi.org/10.1038/s41598-020-61515-z |
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ENVELOPE(-62.917,-62.917,-64.300,-64.300) |
geographic |
Eta |
geographic_facet |
Eta |
genre |
Meganyctiphanes norvegica |
genre_facet |
Meganyctiphanes norvegica |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080843/ http://www.ncbi.nlm.nih.gov/pubmed/32188923 http://dx.doi.org/10.1038/s41598-020-61515-z |
op_rights |
© The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1038/s41598-020-61515-z |
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Scientific Reports |
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