Genome-wide association identifies seven loci for pelvic organ prolapse in Iceland and the UK Biobank
Pelvic organ prolapse (POP) is a downward descent of one or more of the pelvic organs, resulting in a protrusion of the vaginal wall and/or uterus. We performed a genome-wide association study of POP using data from Iceland and the UK Biobank, a total of 15,010 cases with hospital-based diagnosis co...
Published in: | Communications Biology |
---|---|
Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Format: | Text |
Language: | English |
Published: |
Nature Publishing Group UK
2020
|
Subjects: | |
Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078216/ http://www.ncbi.nlm.nih.gov/pubmed/32184442 https://doi.org/10.1038/s42003-020-0857-9 |
id |
ftpubmed:oai:pubmedcentral.nih.gov:7078216 |
---|---|
record_format |
openpolar |
spelling |
ftpubmed:oai:pubmedcentral.nih.gov:7078216 2023-05-15T16:47:22+02:00 Genome-wide association identifies seven loci for pelvic organ prolapse in Iceland and the UK Biobank Olafsdottir, Thorhildur Thorleifsson, Gudmar Sulem, Patrick Stefansson, Olafur A. Medek, Helga Olafsson, Karl Ingthorsson, Orri Gudmundsson, Valur Jonsdottir, Ingileif Halldorsson, Gisli H. Kristjansson, Ragnar P. Frigge, Michael L. Stefansdottir, Lilja Sigurdsson, Jon K. Oddsson, Asmundur Sigurdsson, Asgeir Eggertsson, Hannes P. Melsted, Pall Halldorsson, Bjarni V. Lund, Sigrun H. Styrkarsdottir, Unnur Steinthorsdottir, Valgerdur Gudmundsson, Julius Holm, Hilma Tragante, Vinicius Asselbergs, Folkert W. Thorsteinsdottir, Unnur Gudbjartsson, Daniel F. Jonsdottir, Kristin Rafnar, Thorunn Stefansson, Kari 2020-03-17 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078216/ http://www.ncbi.nlm.nih.gov/pubmed/32184442 https://doi.org/10.1038/s42003-020-0857-9 en eng Nature Publishing Group UK http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078216/ http://www.ncbi.nlm.nih.gov/pubmed/32184442 http://dx.doi.org/10.1038/s42003-020-0857-9 © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. CC-BY Article Text 2020 ftpubmed https://doi.org/10.1038/s42003-020-0857-9 2020-03-22T01:54:38Z Pelvic organ prolapse (POP) is a downward descent of one or more of the pelvic organs, resulting in a protrusion of the vaginal wall and/or uterus. We performed a genome-wide association study of POP using data from Iceland and the UK Biobank, a total of 15,010 cases with hospital-based diagnosis code and 340,734 female controls, and found eight sequence variants at seven loci associating with POP (P < 5 × 10(−8)); seven common (minor allele frequency >5%) and one with minor allele frequency of 4.87%. Some of the variants associating with POP also associated with traits of similar pathophysiology. Of these, rs3820282, which may alter the estrogen-based regulation of WNT4, also associates with leiomyoma of uterus, gestational duration and endometriosis. Rs3791675 at EFEMP1, a gene involved in connective tissue homeostasis, also associates with hernias and carpal tunnel syndrome. Our results highlight the role of connective tissue metabolism and estrogen exposure in the etiology of POP. Text Iceland PubMed Central (PMC) Communications Biology 3 1 |
institution |
Open Polar |
collection |
PubMed Central (PMC) |
op_collection_id |
ftpubmed |
language |
English |
topic |
Article |
spellingShingle |
Article Olafsdottir, Thorhildur Thorleifsson, Gudmar Sulem, Patrick Stefansson, Olafur A. Medek, Helga Olafsson, Karl Ingthorsson, Orri Gudmundsson, Valur Jonsdottir, Ingileif Halldorsson, Gisli H. Kristjansson, Ragnar P. Frigge, Michael L. Stefansdottir, Lilja Sigurdsson, Jon K. Oddsson, Asmundur Sigurdsson, Asgeir Eggertsson, Hannes P. Melsted, Pall Halldorsson, Bjarni V. Lund, Sigrun H. Styrkarsdottir, Unnur Steinthorsdottir, Valgerdur Gudmundsson, Julius Holm, Hilma Tragante, Vinicius Asselbergs, Folkert W. Thorsteinsdottir, Unnur Gudbjartsson, Daniel F. Jonsdottir, Kristin Rafnar, Thorunn Stefansson, Kari Genome-wide association identifies seven loci for pelvic organ prolapse in Iceland and the UK Biobank |
topic_facet |
Article |
description |
Pelvic organ prolapse (POP) is a downward descent of one or more of the pelvic organs, resulting in a protrusion of the vaginal wall and/or uterus. We performed a genome-wide association study of POP using data from Iceland and the UK Biobank, a total of 15,010 cases with hospital-based diagnosis code and 340,734 female controls, and found eight sequence variants at seven loci associating with POP (P < 5 × 10(−8)); seven common (minor allele frequency >5%) and one with minor allele frequency of 4.87%. Some of the variants associating with POP also associated with traits of similar pathophysiology. Of these, rs3820282, which may alter the estrogen-based regulation of WNT4, also associates with leiomyoma of uterus, gestational duration and endometriosis. Rs3791675 at EFEMP1, a gene involved in connective tissue homeostasis, also associates with hernias and carpal tunnel syndrome. Our results highlight the role of connective tissue metabolism and estrogen exposure in the etiology of POP. |
format |
Text |
author |
Olafsdottir, Thorhildur Thorleifsson, Gudmar Sulem, Patrick Stefansson, Olafur A. Medek, Helga Olafsson, Karl Ingthorsson, Orri Gudmundsson, Valur Jonsdottir, Ingileif Halldorsson, Gisli H. Kristjansson, Ragnar P. Frigge, Michael L. Stefansdottir, Lilja Sigurdsson, Jon K. Oddsson, Asmundur Sigurdsson, Asgeir Eggertsson, Hannes P. Melsted, Pall Halldorsson, Bjarni V. Lund, Sigrun H. Styrkarsdottir, Unnur Steinthorsdottir, Valgerdur Gudmundsson, Julius Holm, Hilma Tragante, Vinicius Asselbergs, Folkert W. Thorsteinsdottir, Unnur Gudbjartsson, Daniel F. Jonsdottir, Kristin Rafnar, Thorunn Stefansson, Kari |
author_facet |
Olafsdottir, Thorhildur Thorleifsson, Gudmar Sulem, Patrick Stefansson, Olafur A. Medek, Helga Olafsson, Karl Ingthorsson, Orri Gudmundsson, Valur Jonsdottir, Ingileif Halldorsson, Gisli H. Kristjansson, Ragnar P. Frigge, Michael L. Stefansdottir, Lilja Sigurdsson, Jon K. Oddsson, Asmundur Sigurdsson, Asgeir Eggertsson, Hannes P. Melsted, Pall Halldorsson, Bjarni V. Lund, Sigrun H. Styrkarsdottir, Unnur Steinthorsdottir, Valgerdur Gudmundsson, Julius Holm, Hilma Tragante, Vinicius Asselbergs, Folkert W. Thorsteinsdottir, Unnur Gudbjartsson, Daniel F. Jonsdottir, Kristin Rafnar, Thorunn Stefansson, Kari |
author_sort |
Olafsdottir, Thorhildur |
title |
Genome-wide association identifies seven loci for pelvic organ prolapse in Iceland and the UK Biobank |
title_short |
Genome-wide association identifies seven loci for pelvic organ prolapse in Iceland and the UK Biobank |
title_full |
Genome-wide association identifies seven loci for pelvic organ prolapse in Iceland and the UK Biobank |
title_fullStr |
Genome-wide association identifies seven loci for pelvic organ prolapse in Iceland and the UK Biobank |
title_full_unstemmed |
Genome-wide association identifies seven loci for pelvic organ prolapse in Iceland and the UK Biobank |
title_sort |
genome-wide association identifies seven loci for pelvic organ prolapse in iceland and the uk biobank |
publisher |
Nature Publishing Group UK |
publishDate |
2020 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078216/ http://www.ncbi.nlm.nih.gov/pubmed/32184442 https://doi.org/10.1038/s42003-020-0857-9 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078216/ http://www.ncbi.nlm.nih.gov/pubmed/32184442 http://dx.doi.org/10.1038/s42003-020-0857-9 |
op_rights |
© The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1038/s42003-020-0857-9 |
container_title |
Communications Biology |
container_volume |
3 |
container_issue |
1 |
_version_ |
1766037453807812608 |