Reduction of antimicrobial resistant pneumococci seven years after introduction of pneumococcal vaccine in Iceland
BACKGROUND: Penicillin non-susceptible (PNSP) and multi-resistant pneumococci have been prevalent in Iceland since early nineties, mainly causing problems in treatment of acute otitis media. The 10-valent protein conjugated pneumococcal vaccine (PHiD-CV) was introduced into the childhood vaccination...
Published in: | PLOS ONE |
---|---|
Main Authors: | , , , , , |
Format: | Text |
Language: | English |
Published: |
Public Library of Science
2020
|
Subjects: | |
Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077842/ http://www.ncbi.nlm.nih.gov/pubmed/32182260 https://doi.org/10.1371/journal.pone.0230332 |
id |
ftpubmed:oai:pubmedcentral.nih.gov:7077842 |
---|---|
record_format |
openpolar |
spelling |
ftpubmed:oai:pubmedcentral.nih.gov:7077842 2023-05-15T16:46:56+02:00 Reduction of antimicrobial resistant pneumococci seven years after introduction of pneumococcal vaccine in Iceland Hjálmarsdóttir, Martha Á. Haraldsson, Gunnsteinn Quirk, Sigríður Júlía Haraldsson, Ásgeir Erlendsdóttir, Helga Kristinsson, Karl G. 2020-03-17 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077842/ http://www.ncbi.nlm.nih.gov/pubmed/32182260 https://doi.org/10.1371/journal.pone.0230332 en eng Public Library of Science http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077842/ http://www.ncbi.nlm.nih.gov/pubmed/32182260 http://dx.doi.org/10.1371/journal.pone.0230332 © 2020 Hjálmarsdóttir et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. CC-BY Research Article Text 2020 ftpubmed https://doi.org/10.1371/journal.pone.0230332 2020-03-29T01:27:35Z BACKGROUND: Penicillin non-susceptible (PNSP) and multi-resistant pneumococci have been prevalent in Iceland since early nineties, mainly causing problems in treatment of acute otitis media. The 10-valent protein conjugated pneumococcal vaccine (PHiD-CV) was introduced into the childhood vaccination program in 2011. The aim of the study was to investigate the changes in antimicrobial susceptibility and serotype distribution of penicillin non-susceptible pneumococci (PNSP) in Iceland 2011–2017. METHODS AND FINDINGS: All pneumococcal isolates identified at the Landspítali University Hospital in 2011–2017, excluding isolates from the nasopharynx and throat were studied. Susceptibility testing was done according to the EUCAST guidelines using disk diffusion with chloramphenicol, erythromycin, clindamycin, tetracycline, trimethoprim/sulfamethoxazole and oxacillin for PNSP screening. Penicillin and ceftriaxone minimum inhibitory concentrations (MIC) were measured for oxacillin resistant isolates using the E-test. Serotyping was done using latex agglutination and/or multiplex PCR. The total number of pneumococcal isolates that met the study criteria was 1,706, of which 516 (30.2%) were PNSP, and declining with time. PNSP isolates of PHiD-CV vaccine serotypes (VT) were 362/516 (70.2%) declining with time, 132/143 (92.3%) in 2011 and 17/54 (31.5%) in 2017. PNSP were most commonly of serotype 19F, 317/516 isolates declining with time, 124/143 in 2011 and 15/54 in 2017. Their number decreased in all age groups, but mainly in the youngest children. PNSP isolates of non PHiD-CV vaccine serotypes (NVT) were 154/516, increasing with time, 11/14, in 2011 and 37/54 in 2017. The most common emerging NVTs in 2011 and 2017 were 6C, 1/143 and 10/54 respectively. CONCLUSIONS: PNSP of VTs have virtually disappeared from children with pneumococcal diseases after the initiation of pneumococcal vaccination in Iceland and a clear herd effect was observed. This was mainly driven by a decrease of PNSP isolates belonging to a serotype 19F ... Text Iceland PubMed Central (PMC) PLOS ONE 15 3 e0230332 |
institution |
Open Polar |
collection |
PubMed Central (PMC) |
op_collection_id |
ftpubmed |
language |
English |
topic |
Research Article |
spellingShingle |
Research Article Hjálmarsdóttir, Martha Á. Haraldsson, Gunnsteinn Quirk, Sigríður Júlía Haraldsson, Ásgeir Erlendsdóttir, Helga Kristinsson, Karl G. Reduction of antimicrobial resistant pneumococci seven years after introduction of pneumococcal vaccine in Iceland |
topic_facet |
Research Article |
description |
BACKGROUND: Penicillin non-susceptible (PNSP) and multi-resistant pneumococci have been prevalent in Iceland since early nineties, mainly causing problems in treatment of acute otitis media. The 10-valent protein conjugated pneumococcal vaccine (PHiD-CV) was introduced into the childhood vaccination program in 2011. The aim of the study was to investigate the changes in antimicrobial susceptibility and serotype distribution of penicillin non-susceptible pneumococci (PNSP) in Iceland 2011–2017. METHODS AND FINDINGS: All pneumococcal isolates identified at the Landspítali University Hospital in 2011–2017, excluding isolates from the nasopharynx and throat were studied. Susceptibility testing was done according to the EUCAST guidelines using disk diffusion with chloramphenicol, erythromycin, clindamycin, tetracycline, trimethoprim/sulfamethoxazole and oxacillin for PNSP screening. Penicillin and ceftriaxone minimum inhibitory concentrations (MIC) were measured for oxacillin resistant isolates using the E-test. Serotyping was done using latex agglutination and/or multiplex PCR. The total number of pneumococcal isolates that met the study criteria was 1,706, of which 516 (30.2%) were PNSP, and declining with time. PNSP isolates of PHiD-CV vaccine serotypes (VT) were 362/516 (70.2%) declining with time, 132/143 (92.3%) in 2011 and 17/54 (31.5%) in 2017. PNSP were most commonly of serotype 19F, 317/516 isolates declining with time, 124/143 in 2011 and 15/54 in 2017. Their number decreased in all age groups, but mainly in the youngest children. PNSP isolates of non PHiD-CV vaccine serotypes (NVT) were 154/516, increasing with time, 11/14, in 2011 and 37/54 in 2017. The most common emerging NVTs in 2011 and 2017 were 6C, 1/143 and 10/54 respectively. CONCLUSIONS: PNSP of VTs have virtually disappeared from children with pneumococcal diseases after the initiation of pneumococcal vaccination in Iceland and a clear herd effect was observed. This was mainly driven by a decrease of PNSP isolates belonging to a serotype 19F ... |
format |
Text |
author |
Hjálmarsdóttir, Martha Á. Haraldsson, Gunnsteinn Quirk, Sigríður Júlía Haraldsson, Ásgeir Erlendsdóttir, Helga Kristinsson, Karl G. |
author_facet |
Hjálmarsdóttir, Martha Á. Haraldsson, Gunnsteinn Quirk, Sigríður Júlía Haraldsson, Ásgeir Erlendsdóttir, Helga Kristinsson, Karl G. |
author_sort |
Hjálmarsdóttir, Martha Á. |
title |
Reduction of antimicrobial resistant pneumococci seven years after introduction of pneumococcal vaccine in Iceland |
title_short |
Reduction of antimicrobial resistant pneumococci seven years after introduction of pneumococcal vaccine in Iceland |
title_full |
Reduction of antimicrobial resistant pneumococci seven years after introduction of pneumococcal vaccine in Iceland |
title_fullStr |
Reduction of antimicrobial resistant pneumococci seven years after introduction of pneumococcal vaccine in Iceland |
title_full_unstemmed |
Reduction of antimicrobial resistant pneumococci seven years after introduction of pneumococcal vaccine in Iceland |
title_sort |
reduction of antimicrobial resistant pneumococci seven years after introduction of pneumococcal vaccine in iceland |
publisher |
Public Library of Science |
publishDate |
2020 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077842/ http://www.ncbi.nlm.nih.gov/pubmed/32182260 https://doi.org/10.1371/journal.pone.0230332 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077842/ http://www.ncbi.nlm.nih.gov/pubmed/32182260 http://dx.doi.org/10.1371/journal.pone.0230332 |
op_rights |
© 2020 Hjálmarsdóttir et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1371/journal.pone.0230332 |
container_title |
PLOS ONE |
container_volume |
15 |
container_issue |
3 |
container_start_page |
e0230332 |
_version_ |
1766037027886727168 |