Immunolocalization of aromatase P450 in the epididymis of Podarcis sicula and Rattus rattus
The goal of this study was to evaluate P450 aromatase localization in the epididymis of two different vertebrates: the lizard Podarcis sicula, a seasonal breeder, and Rattus rattus, a continuous breeder. P450 aromatase is a key enzyme involved in the local control of spermatogenesis and steroidogene...
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PAGEPress Publications, Pavia, Italy
2020
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Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7029622/ http://www.ncbi.nlm.nih.gov/pubmed/31988532 https://doi.org/10.4081/ejh.2020.3080 |
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ftpubmed:oai:pubmedcentral.nih.gov:7029622 2023-05-15T18:04:54+02:00 Immunolocalization of aromatase P450 in the epididymis of Podarcis sicula and Rattus rattus Rosati, Luigi Prisco, Marina Lorenzo, Mariana Di Falco, Maria De Andreuccetti, Piero 2020-01-27 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7029622/ http://www.ncbi.nlm.nih.gov/pubmed/31988532 https://doi.org/10.4081/ejh.2020.3080 en eng PAGEPress Publications, Pavia, Italy http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7029622/ http://www.ncbi.nlm.nih.gov/pubmed/31988532 http://dx.doi.org/10.4081/ejh.2020.3080 ©Copyright: the Author(s), 2020 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License (by-nc 4.0) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. CC-BY-NC Article Text 2020 ftpubmed https://doi.org/10.4081/ejh.2020.3080 2020-03-08T01:33:24Z The goal of this study was to evaluate P450 aromatase localization in the epididymis of two different vertebrates: the lizard Podarcis sicula, a seasonal breeder, and Rattus rattus, a continuous breeder. P450 aromatase is a key enzyme involved in the local control of spermatogenesis and steroidogenesis and we proved for the first time that this enzyme is represented in the epididymis of both P. sicula and R. rattus. In details, P450 aromatase was well represented in epithelial and myoid cells and in the connective tissue of P. sicula epididymis during the reproductive period; instead, during autumnal resumption this enzyme was absent in the connective tissue. During the non-reproductive period, P450 aromatase was localized only in myoid cells of P. sicula epididymis, whereas in R. rattus it was localized both in myoid cells and connective tissue. Our findings, the first on the epididymis aromatase localization in the vertebrates, suggest a possible role of P450 aromatase in the control of male genital tract function, particularly in sperm maturation. Text Rattus rattus PubMed Central (PMC) European Journal of Histochemistry 64 1 |
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Article Rosati, Luigi Prisco, Marina Lorenzo, Mariana Di Falco, Maria De Andreuccetti, Piero Immunolocalization of aromatase P450 in the epididymis of Podarcis sicula and Rattus rattus |
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Article |
description |
The goal of this study was to evaluate P450 aromatase localization in the epididymis of two different vertebrates: the lizard Podarcis sicula, a seasonal breeder, and Rattus rattus, a continuous breeder. P450 aromatase is a key enzyme involved in the local control of spermatogenesis and steroidogenesis and we proved for the first time that this enzyme is represented in the epididymis of both P. sicula and R. rattus. In details, P450 aromatase was well represented in epithelial and myoid cells and in the connective tissue of P. sicula epididymis during the reproductive period; instead, during autumnal resumption this enzyme was absent in the connective tissue. During the non-reproductive period, P450 aromatase was localized only in myoid cells of P. sicula epididymis, whereas in R. rattus it was localized both in myoid cells and connective tissue. Our findings, the first on the epididymis aromatase localization in the vertebrates, suggest a possible role of P450 aromatase in the control of male genital tract function, particularly in sperm maturation. |
format |
Text |
author |
Rosati, Luigi Prisco, Marina Lorenzo, Mariana Di Falco, Maria De Andreuccetti, Piero |
author_facet |
Rosati, Luigi Prisco, Marina Lorenzo, Mariana Di Falco, Maria De Andreuccetti, Piero |
author_sort |
Rosati, Luigi |
title |
Immunolocalization of aromatase P450 in the epididymis of Podarcis sicula and Rattus rattus |
title_short |
Immunolocalization of aromatase P450 in the epididymis of Podarcis sicula and Rattus rattus |
title_full |
Immunolocalization of aromatase P450 in the epididymis of Podarcis sicula and Rattus rattus |
title_fullStr |
Immunolocalization of aromatase P450 in the epididymis of Podarcis sicula and Rattus rattus |
title_full_unstemmed |
Immunolocalization of aromatase P450 in the epididymis of Podarcis sicula and Rattus rattus |
title_sort |
immunolocalization of aromatase p450 in the epididymis of podarcis sicula and rattus rattus |
publisher |
PAGEPress Publications, Pavia, Italy |
publishDate |
2020 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7029622/ http://www.ncbi.nlm.nih.gov/pubmed/31988532 https://doi.org/10.4081/ejh.2020.3080 |
genre |
Rattus rattus |
genre_facet |
Rattus rattus |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7029622/ http://www.ncbi.nlm.nih.gov/pubmed/31988532 http://dx.doi.org/10.4081/ejh.2020.3080 |
op_rights |
©Copyright: the Author(s), 2020 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License (by-nc 4.0) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. |
op_rightsnorm |
CC-BY-NC |
op_doi |
https://doi.org/10.4081/ejh.2020.3080 |
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European Journal of Histochemistry |
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64 |
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1 |
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1766176315393703936 |