Persistence of human papillomavirus 16, 18 and 52 variants in Inuit women from Northern Quebec, Canada
Intratypic DNA polymorphism has been described for human papillomavirus (HPV) types infecting Inuit women in Nunavik, Quebec, a high-risk population for HPV infection and cervical cancer, but there is no previous research on the association between HPV polymorphism and infection persistence in Inuit...
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ftpubmed:oai:pubmedcentral.nih.gov:7011783 2023-05-15T16:54:31+02:00 Persistence of human papillomavirus 16, 18 and 52 variants in Inuit women from Northern Quebec, Canada Gauthier, Barbara Cerigo, Helen Coutlée, François Franco, Eduardo L. Brassard, Paul 2019-02-14 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011783/ http://www.ncbi.nlm.nih.gov/pubmed/30827197 https://doi.org/10.1080/22423982.2018.1556556 en eng Taylor & Francis http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011783/ http://www.ncbi.nlm.nih.gov/pubmed/30827197 http://dx.doi.org/10.1080/22423982.2018.1556556 © 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. CC-BY-NC Research Article Text 2019 ftpubmed https://doi.org/10.1080/22423982.2018.1556556 2020-03-01T01:21:02Z Intratypic DNA polymorphism has been described for human papillomavirus (HPV) types infecting Inuit women in Nunavik, Quebec, a high-risk population for HPV infection and cervical cancer, but there is no previous research on the association between HPV polymorphism and infection persistence in Inuit women. Polymorphism of HPV types 16, 18 and 52 was described in a subset of 64 participants with multiple clinic visits within a cohort of 677 Nunavik Inuit women aged 15–69 recruited in 2002–2010 with testing results. Logistic regression and Cox proportional hazards models were used to assess the association between HPV variants and infection persistence and clearance. Infections with HPV16 lineage A3 variants cleared 3.13 times faster (95% CI: 1.10–8.97) than those with lineage A1 variants. HPV52 lineage C variants cleared slower than lineage A variants (HR = 0.28, 95% CI: 0.08–0.98). HPV polymorphism may be associated with viral persistence for certain HPV types in this population. Text inuit Nunavik PubMed Central (PMC) Canada Nunavik International Journal of Circumpolar Health 77 1 1556556 |
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Research Article Gauthier, Barbara Cerigo, Helen Coutlée, François Franco, Eduardo L. Brassard, Paul Persistence of human papillomavirus 16, 18 and 52 variants in Inuit women from Northern Quebec, Canada |
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Research Article |
description |
Intratypic DNA polymorphism has been described for human papillomavirus (HPV) types infecting Inuit women in Nunavik, Quebec, a high-risk population for HPV infection and cervical cancer, but there is no previous research on the association between HPV polymorphism and infection persistence in Inuit women. Polymorphism of HPV types 16, 18 and 52 was described in a subset of 64 participants with multiple clinic visits within a cohort of 677 Nunavik Inuit women aged 15–69 recruited in 2002–2010 with testing results. Logistic regression and Cox proportional hazards models were used to assess the association between HPV variants and infection persistence and clearance. Infections with HPV16 lineage A3 variants cleared 3.13 times faster (95% CI: 1.10–8.97) than those with lineage A1 variants. HPV52 lineage C variants cleared slower than lineage A variants (HR = 0.28, 95% CI: 0.08–0.98). HPV polymorphism may be associated with viral persistence for certain HPV types in this population. |
format |
Text |
author |
Gauthier, Barbara Cerigo, Helen Coutlée, François Franco, Eduardo L. Brassard, Paul |
author_facet |
Gauthier, Barbara Cerigo, Helen Coutlée, François Franco, Eduardo L. Brassard, Paul |
author_sort |
Gauthier, Barbara |
title |
Persistence of human papillomavirus 16, 18 and 52 variants in Inuit women from Northern Quebec, Canada |
title_short |
Persistence of human papillomavirus 16, 18 and 52 variants in Inuit women from Northern Quebec, Canada |
title_full |
Persistence of human papillomavirus 16, 18 and 52 variants in Inuit women from Northern Quebec, Canada |
title_fullStr |
Persistence of human papillomavirus 16, 18 and 52 variants in Inuit women from Northern Quebec, Canada |
title_full_unstemmed |
Persistence of human papillomavirus 16, 18 and 52 variants in Inuit women from Northern Quebec, Canada |
title_sort |
persistence of human papillomavirus 16, 18 and 52 variants in inuit women from northern quebec, canada |
publisher |
Taylor & Francis |
publishDate |
2019 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011783/ http://www.ncbi.nlm.nih.gov/pubmed/30827197 https://doi.org/10.1080/22423982.2018.1556556 |
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Canada Nunavik |
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Canada Nunavik |
genre |
inuit Nunavik |
genre_facet |
inuit Nunavik |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011783/ http://www.ncbi.nlm.nih.gov/pubmed/30827197 http://dx.doi.org/10.1080/22423982.2018.1556556 |
op_rights |
© 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
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CC-BY-NC |
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https://doi.org/10.1080/22423982.2018.1556556 |
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International Journal of Circumpolar Health |
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77 |
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1 |
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1556556 |
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1766045201169645568 |