Safety and efficacy of OPTIPHOS (®) (6‐phytase) as a feed additive for finfish
The additive OPTIPHOS (®) is a preparation of 6‐phytase that is authorised for use in avian species, weaned piglets, pigs for fattening and sows. The applicant seeks for an extension of use of the product to finfish, at a dose range between 250 and 1,000 OTU/kg feed. The FEEDAP Panel concluded in a...
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ftpubmed:oai:pubmedcentral.nih.gov:7010092 2023-05-15T15:31:54+02:00 Safety and efficacy of OPTIPHOS (®) (6‐phytase) as a feed additive for finfish Rychen, Guido Aquilina, Gabriele Azimonti, Giovanna Bampidis, Vasileios Bastos, Maria de Lourdes Bories, Georges Chesson, Andrew Cocconcelli, Pier Sandro Flachowsky, Gerhard Gropp, Jürgen Kolar, Boris Kouba, Maryline López Alonso, Marta López Puente, Secundino Mantovani, Alberto Mayo, Baltasar Ramos, Fernando Saarela, Maria Villa, Roberto Edoardo Wallace, Robert John Wester, Pieter Brantom, Paul Dierick, Noël Albert Anguita, Montserrat 2017-04-12 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010092/ https://doi.org/10.2903/j.efsa.2017.4763 en eng John Wiley and Sons Inc. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010092/ http://dx.doi.org/10.2903/j.efsa.2017.4763 © 2017 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited and no modifications or adaptations are made. CC-BY-ND EFSA J Scientific Opinion Text 2017 ftpubmed https://doi.org/10.2903/j.efsa.2017.4763 2020-07-05T00:34:10Z The additive OPTIPHOS (®) is a preparation of 6‐phytase that is authorised for use in avian species, weaned piglets, pigs for fattening and sows. The applicant seeks for an extension of use of the product to finfish, at a dose range between 250 and 1,000 OTU/kg feed. The FEEDAP Panel concluded in a previous opinion that there are no concerns for consumer safety and no risks for the environment are expected from the use of the product as feed additive. Moreover, it was concluded that the additive is not a skin/eye irritant or a skin sensitiser, but has the potential to be a respiratory sensitiser. The Panel considered that the new use of the additive would not change the previous conclusions regarding the safety for the consumer, user and environment. The results of a tolerance study performed in juvenile rainbow trout (Oncorhynchus mykiss) showed no negative effects of the additive on the fish when offered up to 100 times the maximum recommended dose. Therefore, the Panel concluded that the additive is safe for the rainbow trout and extrapolated this conclusion to all finfish. The Panel evaluated three efficacy trials, two performed in rainbow trout and one in Atlantic salmon (Salmo salar). In these studies, the performance of the fish was monitored as well as phosphorus digestibility and phosphorus retention parameters. In the three trials, the performance and the phosphorus retention were improved by the additive at the lowest tested dose (in rainbow trouts at 250 OTU/kg feed and in Atlantic salmon at 500 OTU/kg feed). The FEEDAP Panel concluded that the additive has a potential to be efficacious in rainbow trout and salmon at 500 OTU/kg. The Panel extrapolated the conclusion to all finfish species. Text Atlantic salmon Salmo salar PubMed Central (PMC) EFSA Journal 15 4 |
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Scientific Opinion |
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Scientific Opinion Rychen, Guido Aquilina, Gabriele Azimonti, Giovanna Bampidis, Vasileios Bastos, Maria de Lourdes Bories, Georges Chesson, Andrew Cocconcelli, Pier Sandro Flachowsky, Gerhard Gropp, Jürgen Kolar, Boris Kouba, Maryline López Alonso, Marta López Puente, Secundino Mantovani, Alberto Mayo, Baltasar Ramos, Fernando Saarela, Maria Villa, Roberto Edoardo Wallace, Robert John Wester, Pieter Brantom, Paul Dierick, Noël Albert Anguita, Montserrat Safety and efficacy of OPTIPHOS (®) (6‐phytase) as a feed additive for finfish |
topic_facet |
Scientific Opinion |
description |
The additive OPTIPHOS (®) is a preparation of 6‐phytase that is authorised for use in avian species, weaned piglets, pigs for fattening and sows. The applicant seeks for an extension of use of the product to finfish, at a dose range between 250 and 1,000 OTU/kg feed. The FEEDAP Panel concluded in a previous opinion that there are no concerns for consumer safety and no risks for the environment are expected from the use of the product as feed additive. Moreover, it was concluded that the additive is not a skin/eye irritant or a skin sensitiser, but has the potential to be a respiratory sensitiser. The Panel considered that the new use of the additive would not change the previous conclusions regarding the safety for the consumer, user and environment. The results of a tolerance study performed in juvenile rainbow trout (Oncorhynchus mykiss) showed no negative effects of the additive on the fish when offered up to 100 times the maximum recommended dose. Therefore, the Panel concluded that the additive is safe for the rainbow trout and extrapolated this conclusion to all finfish. The Panel evaluated three efficacy trials, two performed in rainbow trout and one in Atlantic salmon (Salmo salar). In these studies, the performance of the fish was monitored as well as phosphorus digestibility and phosphorus retention parameters. In the three trials, the performance and the phosphorus retention were improved by the additive at the lowest tested dose (in rainbow trouts at 250 OTU/kg feed and in Atlantic salmon at 500 OTU/kg feed). The FEEDAP Panel concluded that the additive has a potential to be efficacious in rainbow trout and salmon at 500 OTU/kg. The Panel extrapolated the conclusion to all finfish species. |
format |
Text |
author |
Rychen, Guido Aquilina, Gabriele Azimonti, Giovanna Bampidis, Vasileios Bastos, Maria de Lourdes Bories, Georges Chesson, Andrew Cocconcelli, Pier Sandro Flachowsky, Gerhard Gropp, Jürgen Kolar, Boris Kouba, Maryline López Alonso, Marta López Puente, Secundino Mantovani, Alberto Mayo, Baltasar Ramos, Fernando Saarela, Maria Villa, Roberto Edoardo Wallace, Robert John Wester, Pieter Brantom, Paul Dierick, Noël Albert Anguita, Montserrat |
author_facet |
Rychen, Guido Aquilina, Gabriele Azimonti, Giovanna Bampidis, Vasileios Bastos, Maria de Lourdes Bories, Georges Chesson, Andrew Cocconcelli, Pier Sandro Flachowsky, Gerhard Gropp, Jürgen Kolar, Boris Kouba, Maryline López Alonso, Marta López Puente, Secundino Mantovani, Alberto Mayo, Baltasar Ramos, Fernando Saarela, Maria Villa, Roberto Edoardo Wallace, Robert John Wester, Pieter Brantom, Paul Dierick, Noël Albert Anguita, Montserrat |
author_sort |
Rychen, Guido |
title |
Safety and efficacy of OPTIPHOS (®) (6‐phytase) as a feed additive for finfish |
title_short |
Safety and efficacy of OPTIPHOS (®) (6‐phytase) as a feed additive for finfish |
title_full |
Safety and efficacy of OPTIPHOS (®) (6‐phytase) as a feed additive for finfish |
title_fullStr |
Safety and efficacy of OPTIPHOS (®) (6‐phytase) as a feed additive for finfish |
title_full_unstemmed |
Safety and efficacy of OPTIPHOS (®) (6‐phytase) as a feed additive for finfish |
title_sort |
safety and efficacy of optiphos (®) (6‐phytase) as a feed additive for finfish |
publisher |
John Wiley and Sons Inc. |
publishDate |
2017 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010092/ https://doi.org/10.2903/j.efsa.2017.4763 |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_source |
EFSA J |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010092/ http://dx.doi.org/10.2903/j.efsa.2017.4763 |
op_rights |
© 2017 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited and no modifications or adaptations are made. |
op_rightsnorm |
CC-BY-ND |
op_doi |
https://doi.org/10.2903/j.efsa.2017.4763 |
container_title |
EFSA Journal |
container_volume |
15 |
container_issue |
4 |
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1766362405781110784 |